A VOC Dosimeter Based On A Colorimetric Sensor Array

基于比色传感器阵列的 VOC 剂量计

基本信息

批准号：
7485179
负责人：
Kenneth S Suslick
金额：
$ 63.55万
依托单位：
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-08-15 至 2011-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7485179
关键词：
Acids Address Alcohols Aldehydes Amines Area Arts Automation Bacteria Carboxylic Acids Categories Cations Charge Chemical Agents Chemical Exposure Chemicals Chlorine Class Clip Clothing Color Colorimetry Computer software Consumption Data Detection Development Devices Dyes Electronics Emerging Technologies Environmental Exposure Equilibrium Esters Ethylene Oxide Exposure to Funding Future Gases Generations Grant Growth Hemeproteins Human Hypochlorite Image Analysis Intervention Ketones Laboratories Lead Libraries Measurement Measures Metabolic Metalloporphyrins Methods Microspheres Miniaturization Modality Monitor Nose Numbers Optical Readers Ozone Pattern Recognition Phase Population Population Heterogeneity Population Study Principal Investigator Printing Psyche structure Purpose Range Reaction Time Reader Research Personnel Security Sensitivity and Specificity Smell Perception Solutions Spottings Sulfhydryl Compounds System Technology Telemetry Testing Time Wireless Technology Work Workplace analog aqueous base chemical property chlorine dioxide commercialization detector digital environmental chemical exposed human population improved interest miniaturize molecular recognition new technology portability prototype radius bone structure rapid detection response sensor size small molecule tool toxic industrial chemical toxicant volatile organic compound

项目摘要

DESCRIPTION (provided by applicant): The investigators have invented a very simple, but extremely powerful, new technology for detection and identification of volatile organic compounds (VOCs): colorimetric sensor arrays. These are inexpensive, disposable sensor arrays based on equilibrium interactions of analytes with metalloporphyrins and other chemically responsive dyes. As with human olfaction, our colorimetric sensor arrays use a large number of cross-reactive sensors that probe a wide range of chemical properties. By digitally monitoring the change in color of each dye in the array, they have a quantitative measure of a composite response to volatile organics. Chemometric pattern recognition is extremely powerful with these arrays because of their very high dimensionality. the investigators are now extending this work to biomedical applications, with specific aims focusing on the development of a personal chemical dosimeter for the detection, identification, and quantification of environmental/workplace VOCs. The sensitivity of the arrays permits rapid detection of very low levels of most volatile toxicants. This is a translational technology that should find substantial use in workplace monitoring of chemical exposure. Their efforts in these areas should lead (1) to fundamental advances in sensor development for molecular recognition and biomedical applications of such sensor arrays, (2) development and refinement of technology for the rapid and continuous identification and quantitation of volatile chemical toxicants, and most importantly, (3) prototyping of an extremely portable device for the assessment of personal VOC exposure; this device will provide continuous, quantitative, reliable, reproducible, multiplexed measurement of environmental exposures with rapid response (i.e., seconds) that requires essentially no user intervention for field deployment and data capture. This self-contained, easy-to-use device will prove ideal for multi-analyte measurement of point-of-contact exposures to priority environmental chemicals for use within future population-based biomedical studies of diverse populations. The device will be able to measure analyte concentrations continuously, will require essentially no user intervention for field deployment and data capture, and will be capable of real-time telemetry to a centralized system.

描述（由申请人提供）：研究人员发明了一种非常简单但功能极其强大的新技术，用于检测和识别挥发性有机化合物 (VOC)：比色传感器阵列。这些是廉价的一次性传感器阵列，基于分析物与金属卟啉和其他化学响应染料的平衡相互作用。与人类嗅觉一样，我们的比色传感器阵列使用大量交叉反应传感器来探测各种化学特性。通过数字化监测阵列中每种染料颜色的变化，他们可以定量测量对挥发性有机物的复合反应。由于这些阵列的维数非常高，化学计量模式识别功能非常强大。研究人员现在正在将这项工作扩展到生物医学应用，具体目标是开发用于检测、识别和量化环境/工作场所挥发性有机化合物的个人化学剂量计。阵列的灵敏度允许快速检测极低水平的大多数挥发性毒物。这是一项转化技术，应该在工作场所化学品暴露监测中得到广泛应用。他们在这些领域的努力应该导致（1）在分子识别传感器开发和此类传感器阵列的生物医学应用方面取得根本性进展，（2）开发和完善用于快速、连续识别和定量挥发性化学毒物的技术，以及大多数重要的是，(3) 用于评估个人 VOC 暴露的极其便携的设备原型设计；该设备将提供连续、定量、可靠、可重复、多重的环境暴露测量，并具有快速响应（即几秒），基本上不需要用户干预现场部署和数据采集。这种独立、易于使用的设备将被证明是对接触点暴露于优先环境化学品的多分析物测量的理想选择，可用于未来基于人群的不同人群的生物医学研究。该设备将能够连续测量分析物浓度，现场部署和数据捕获基本上不需要用户干预，并且能够对集中系统进行实时遥测。