A VOC Dosimeter Based On A Colorimetric Sensor Array

基于比色传感器阵列的 VOC 剂量计

• 批准号: 7638828
• 负责人: Kenneth S Suslick
• 金额: $ 9.58万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-15 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7638828
• 关键词: Acids; Alcohols; Aldehydes; Area; Arts; Bacteria; Categories; Cations; Charge; Chemical Agents; Chemical Exposure; Chemicals; Chlorine; Class; Clip; Clothing; Color; Colorimetry; Computer software; Consumption; Data; Detection; Development; Devices; Dyes; Environmental Exposure; Equilibrium; Esters; Ethylene Oxide; Exposure to; Future; Gases; Generations; Growth; Human; Hypochlorite; Image Analysis; Intervention; Ketones; Lead; Libraries; Measurement; Measures; Metabolic; Metalloporphyrins; Miniaturization; Monitor; Nose; Numbers; Optical Readers; Ozone; Pattern Recognition; Phase; Population; Population Heterogeneity; Printing; Range; Reaction Time; Reader; Smell Perception; Solutions; Spottings; System; Technology; Telemetry; Testing; Time; Wireless Technology; Work; Workplace; aqueous; base; chemical property; chlorine dioxide; detector; digital; environmental chemical; improved; interest; miniaturize; molecular recognition; new technology; prototype; radius bone structure; rapid detection; response; sensor; size; small molecule; toxic industrial chemical; toxicant; volatile organic compound

We have invented a very simple, but extremely powerful, new technology for detection and identification of volatile organic compounds (VOCs): colorimetric sensor arrays. These are inexpensive, disposable sensor arrays based on equilibrium interactions of analytes with metalloporphyrins and other chemically responsive dyes. As with human olfaction, our colorimetric sensor arrays use a large number of cross-reactive sensors that probe a wide range of chemical properties. By digitally monitoring the change in color of each dye in the array, we have a quantitative measure of a composite response to volatile organics. Chemometric pattern recognition is extremely powerful with these arrays because of their very high dimensionality. We are now extending this work to biomedical applications, with specific aims focusing on the development of a personal chemical dosimeter for the detection, identification, and quantification of environmental/workplace VOCs. The sensitivity of our arrays permits rapid detection of very low levels of most volatile toxicants. This is a translational technology that should find substantial use in workplace monitoring of chemical exposure. Our efforts in these areas should lead (1) to fundamental advances in sensor development for molecular recognition and biomedical applications of such sensor arrays, (2) development and refinement of technology for the rapid and continuous identification and quantitation of volatile chemical toxicants, and most importantly, (3) prototyping of an extremely portable device for the assessment of personal VOC exposure; this device will provide continuous, quantitative, reliable, reproducible, multiplexed measurement of environmental exposures with rapid response (i.e., seconds) that requires essentially no user intervention for field deployment and data capture. This self-contained, easy-to-use device will prove ideal for multi- analyte measurement of point-of-contact exposures to priority environmental chemicals for use within future population-based biomedical studies of diverse populations. Our device will be able to measure analyte concentrations continuously, will require essentially no user intervention for field deployment and data capture, and will be capable of real-time telemetry to a centralized system.

我们发明了一种非常简单但功能强大的新技术，用于检测和 挥发性有机化合物（VOC）的识别：比色传感器阵列。这些很便宜， 基于分析物与金属卟啉和其他分析物的平衡相互作用的一次性传感器阵列 化学响应染料。与人类嗅觉一样，我们的比色传感器阵列使用了大量 探测广泛的化学性质的交叉反应传感器。通过数字监视更改 阵列中每个染料的颜色，我们对挥发性有机物的复合响应有一个定量度量。 这些阵列的化学计量模式识别非常强大，因为它们的高度很高 维度。 我们现在将这项工作扩展到生物医学应用，具体目的是 开发用于检测，识别和定量的个人化学剂量表 环境/工作场所VOC。我们阵列的敏感性允许快速检测非常低的水平 大多数挥发性有毒物质。这是一种转化技术，应该在工作场所中找到大量使用 监测化学暴露。 我们在这些领域的努力应导致（1）在传感器开发中的基本进步 此类传感器阵列的识别和生物医学应用，（2）开发和完善 快速，连续鉴定和定量挥发性化学有毒物质的技术，以及 最重要的是，（3）一种非常便携式设备的原型制作，以评估个人VOC 接触;该设备将提供连续的，定量的，可靠的，可重复的，多路复用的测量 具有快速响应的环境暴露（即秒），这基本不需要用户干预 用于现场部署和数据捕获。这种独立，易于使用的设备将被证明是多种多样的 分析物测量接触点对优先环境化学品的接触点暴露于将来 基于人群的生物医学研究。我们的设备将能够测量分析物 浓度不断，本质上不需要用于现场部署和数据的用户干预 捕获，并将能够实时遥测到集中系统。