Neuroimaging and Risk Factor Correlates in Aging and MCI

神经影像学和风险因素与衰老和 MCI 相关

• 批准号: 7486760
• 负责人: Mark W Bondi
• 金额: $ 16.54万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7486760
• 关键词: Address; Adult; Age; Aged, 80 and over; Aging; Alzheimer disease detection; Alzheimer' s Disease; Alzheimer' s disease risk; Apolipoprotein E; Appendix; Autopsy; Award; Brain; California; Cerebrum; Clinical; Clinical Investigator; Clinical Research; Cognitive; Consultations; Count; Dementia; Development; Diagnosis; Diffusion Magnetic Resonance Imaging; Disease; Doctor of Philosophy; Early treatment; Elderly; Episodic memory; Functional Magnetic Resonance Imaging; Funding; Genetic Risk; Genotype; Goals; Gray unit of radiation dose; Human; Image; Investigation; Learning; Liquid substance; Longevity; Magnetic Resonance Imaging; Measures; Medial; Memory; Mentors; Mentorship; Methodology; Monitor; Nature; Neocortex; Neurobiology; Neurofibrillary Tangles; Neuropsychological Tests; Neuropsychology; Onset of illness; Participant; Pathogenesis; Pathologic; Performance; Persons; Phase; Process; Psychiatry; Relative (related person); Reporting; Research; Research Activity; Research Personnel; Risk; Risk Factors; Role; Scientist; Senile Plaques; Sleep; Sleep Deprivation; Spin Labels; Staging; Structure; Synapses; TNFRSF5 gene; Techniques; Temporal Lobe; Therapy Clinical Trials; Time; Training; Universities; Variant; aged; blood oxygen level dependent; career; cognitive function; cost; density; executive function; hemodynamics; indexing; interest; memory encoding; memory process; mild neurocognitive impairment; morphometry; neuroimaging; neuropsychological; patient oriented research; pre-clinical; professor; programs; response; skills; white matter; young adult

DESCRIPTION (provided by applicant): This is a re-revised application for a Mid-Career Investigator Award in Patient-Oriented Research (K24). The candidate, Mark W. Bondi, Ph.D., ABPP/CN, Associate Professor of Psychiatry at the University of California San Diego, proposes to pursue a program of research and mentoring activity on the structural and functional neuroimaging changes related to older persons at risk for Alzheimer's disease (AD). The research plan includes two projects for which the candidate is PI, and one as Co-lnvestigator, all of which have been funded and are ongoing, and new research proposed (see Appendix B). The candidate's career goals are (1) to advance his progress in becoming a leader in the scientific study of neuroimaging changes related to those at risk for AD as well as those with preclinical or early clinical AD; (2) to increase his expertise in both established and emerging neuroimaging techniques for translational efforts in clinical detection of AD, its accurate differentiation from other disorders to which older adults are prone, and potential treatment response to therapeutic trials; and (3) to continue to mentor junior scientists and expand such mentorship to the aforementioned skill domains. He has made a strong commitment to integrating neuropsychological and neuroimaging investigations of persons at genetic risk for AD. Activities for his continued career development include (1) consultation with leading research neuroimaging scientists; (2) didactic and experiential training in emerging functional neuroimaging techniques (e.g., arterial spin labeling, diffusion tensor imaging); (3) participation in departmental and campus-wide neuroimaging seminars and meetings; and (4) expanding his capabilities as a research mentor. Funding of this Mid-Career Investigator Award will provide him with the opportunity to substantially increase the time devoted to clinical research activities, thus enhancing his continued development as a clinical investigator and as a mentor to junior clinician investigators interested in the integration of neuropsychology and neuroimaging. Since little is known concerning the underlying functional brain changes in at-risk groups on susceptible cognitive functions prior to AD onset, this application promises to contribute important new methodologies in the characterization of neurobiological substrates surrounding the development of Alzheimer's disease. If successful, our ability to preclinically detect and monitor Alzheimer's disease will have far-reaching implications for early treatment.

描述（由申请人提供）：这是针对患者研究的中期研究者奖（K24）的重新申请申请。候选人马克·邦迪（Mark W.该研究计划包括两个项目，候选人是PI，一个是共同vestigator，所有这些项目都已资助并且正在进行中，并提出了新的研究（请参阅附录B）。候选人的职业目标是（1）促进他成为与有临床前或早期临床广告患者的神经影像变化的科学研究中的领导者的进步； （2）提高他在建立和新兴的神经影像学技术方面的专业知识，用于转化AD的临床检测，其与老年人容易发生的其他疾病的准确分化以及对治疗试验的潜在治疗反应； （3）继续指导初级科学家并将这种指导扩展到上述技能领域。他做出了坚定的承诺，以整合对AD遗传风险的人的神经心理学和神经影像学调查。他持续的职业发展活动包括（1）与领先的研究神经影像学家进行协​​商； （2）新兴功能神经成像技术中的教学和体验训练（例如，动脉自旋标记，扩散张量成像）； （3）参加部门和校园范围内的神经成像研讨会和会议； （4）扩大他作为研究导师的能力。这项职业中期研究者奖的资金将为他提供实质上增加用于临床研究活动的时间，从而增强他作为临床研究者的持续发展，并成为对神经心理学和神经图像融合感兴趣的初级临床研究者的导师。由于在AD发作前易感认知功能的潜在功能群体的潜在功能性大脑变化知之甚少，因此该应用有望为围绕阿尔茨海默氏病发展的神经生物学基材的表征贡献重要的新方法。如果成功，我们临床上检测和监测阿尔茨海默氏病的能力将对早期治疗具有深远的影响。