Training for a New Interdisciplinary Research Workforce in Regenerative Medicine

再生医学新的跨学科研究队伍的培训

基本信息

批准号：
7492911
负责人：
JOHN A KESSLER
金额：
$ 33.14万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-09-30 至 2010-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7492911
关键词：
Academia Achievement Advisory Committees Animal Disease Models Animal Model Antibodies Antigens Applied Research Appointment Area Back Basic Science Biocompatible Materials Bioethics Biological Biological Sciences Biology Biomedical Engineering Biomedical Research Biotechnology Book Chapters Books Businesses Case Study Cell Therapy Cell Transplants Cells Cellular biology Characteristics Charge Chemistry Chicago Child Clinical Clinical Medicine Clinical Sciences Clinical Trials Cohort Studies Collaborations Commit Committee Members Communication Communities Community Services Complement Computers Country Data Data Analyses Dental Development Developmental Biology Diagnostic Discipline Doctor of Philosophy Drug Delivery Systems Drug Industry Education Educational Curriculum Educational process of instructing Educational workshop Effectiveness Elements Emerging Technologies Employment Engineering Ensure Environment Equilibrium Ethical Issues Ethics Ethnic Origin Evaluation Event Extracellular Matrix Faculty Family Family Practice Feedback Fellowship Female Financial Support Focus Groups Forensic Sciences Fostering Funding Funding Mechanisms Funding Opportunities Future Gender Genetic Genomics Goals Government Graduate Education Grant Growth Guanosine Monophosphate Hand Healthcare Hematopoietic System Home environment Hour Human Human Genome Project Human Resources Humanities Image Immune Tolerance Immune response Immunology In Vitro Individual Industry Influentials Institutes Institution Instruction Intellectual Property Interdisciplinary Study International Internet Internships Interview Job Application Joints Journals Koreans Laboratories Laws Lead Leadership Learning Legal patent Letters Life Logistics Mails Marketing Measures Mediation Medical Device Medical Research Medicine Mentors Methodology Methods Microbiology Minority Modeling Modification Molecular Monitor Morals Museums Nanotechnology Natural regeneration Nature Nervous System Trauma Numbers Occupations Oral Organ Orthopedics Outcome Participant Pathway interactions Patients Perception Performance Physicians Population Positioning Attribute Postdoctoral Fellow Procedures Process Productivity Program Development Program Evaluation Property Public Policy Publications Published Comment Publishing Purpose Qualifying Questionnaires Race Range Recommendation Recruitment Activity Regenerative Medicine Regulation Rehabilitation therapy Reporting Research Research Personnel Research Project Grants Research Training Resources Rest Rewards Robotics Safety Schedule Schools Science Scientist Series Services Side Societies Source Standards of Weights and Measures Stem Cell Research Stem cell transplant Stem cells Structure Student Selections Students Supervision Support of Research Surface Surveys Talents Techniques Technology Technology Transfer Therapeutic Thinking Tissue Engineering Tissues Toxicology Training Training Programs Translating Translational Research Transplantation United States National Institutes of Health Universities User-Computer Interface Visit Woman Work Wound Healing Writing adult stem cell base body system career cell mediated immune response concept day design embryonic stem cell experience extracellular falls feeding follow-up follower of religion Jewish gene therapy grasp human stem cells in vivo interdisciplinary approach interest intimate behavior journal article medical schools member nanomaterials nanomedicine nanoparticle nanopattern nanoscience nerve stem cell novel strategies organ regeneration peer physical science pluripotency posters pre-doctoral programs prospective reconstitution relating to nervous system repaired scaffold size skills skills training social soft drink success symposium synthetic biology tissue regeneration tool

项目摘要

DESCRIPTION (provided by applicant): Regenerative medicine is one of the great biomedical challenges of this century, requiring research at the interface of the physical and life sciences as well as engineering. Cell-based therapies for tissue and organ regeneration will involve not only stem cell biology but also the crafting of bioactive matrices to support tissue growth. This will require cutting- edge supramolecular chemistry, nanotechnology, and micro scale process engineering. In addition, understanding and regulating immune responses to regenerated tissues will be essential for long term survival and function of reconstituted organs. The most effective regenerative strategies will include not only cell-based therapies but also the development of man-machine interfaces, particularly in the case of the damaged nervous system. No single discipline is likely to be able to overcome all of the obstacles to developing techniques for repairing or regenerating damaged tissues and organs. It is therefore necessary to design and implement programs that fuse disparate disciplines into a unified effort to achieve the goals of regenerative medicine. The goal of this training program is to provide predoctoral and postdoctoral trainees with integrated interdisciplinary training in this area. The training faculty members represent 10 different departments/divisions in the Feinberg School of Medicine, 3 departments in the McCormick School of Engineering and Applied Sciences, 2 departments/divisions at Children's Medical Research Center, and 1 department at the Rehabilitation Institute of Chicago. Collectively the preceptors include 5MD PhDs, 12 PhDs, and 3 MDs. The faculty has been carefully constituted to be able to provide oversight in critical areas for the field including stem cell and developmental biology, materials science and nanomedicine, extracellular matrix, immune tolerance to tissues, and neural engineering and robotics. It is anticipated that trainees will be drawn from six unified graduate programs at Northwestern University. Predoctoral trainees selected for the program will fulfill the rigorous requirements for the granting of the PhD degree in their respective programs. Due to the interdisciplinary nature of this research area, the training program core curriculum will have additional unique and non-traditional aspects in which both predoctoral and postdoctoral trainees will participate. The overall theme involves the wedding of bioengineering and materials science with stem cell biology and animal modeling. The goal is to train a cadre of investigators with the requisite interdisciplinary skills necessary both to overcome the barriers to organ and tissue regeneration and to translate advances in the life and physical sciences into clinical medicine.

描述（由申请人提供）：再生医学是本世纪最大的生物医学挑战之一，需要在物理和生命科学以及工程学的交叉领域进行研究。用于组织和器官再生的细胞疗法不仅涉及干细胞生物学，还涉及生物活性基质的制作以支持组织生长。这将需要尖端的超分子化学、纳米技术和微型工艺工程。此外，了解和调节再生组织的免疫反应对于重建器官的长期生存和功能至关重要。最有效的再生策略不仅包括基于细胞的疗法，还包括人机界面的开发，特别是在神经系统受损的情况下。没有任何一门学科能够克服开发修复或再生受损组织和器官技术的所有障碍。因此，有必要设计和实施将不同学科融合为统一努力的计划，以实现再生医学的目标。该培养项目的目标是为博士前和博士后学员提供该领域的综合跨学科培训。培训教师代表范伯格医学院的 10 个不同系/科、麦考密克工程与应用科学学院的 3 个系、儿童医学研究中心的 2 个系/科以及芝加哥康复研究所的 1 个系。导师总数包括 5 名医学博士、12 名博士和 3 名医学博士。该学院经过精心组建，能够对该领域的关键领域提供监督，包括干细胞和发育生物学、材料科学和纳米医学、细胞外基质、组织免疫耐受以及神经工程和机器人技术。预计学员将从西北大学的六个统一研究生项目中选拔。入选该项目的博士前培训生将满足各自项目授予博士学位的严格要求。由于该研究领域的跨学科性质，培训计划的核心课程将具有额外的独特和非传统方面，博士前和博士后学员都将参与其中。总体主题涉及生物工程和材料科学与干细胞生物学和动物建模的结合。目标是培养一支具有必要的跨学科技能的研究人员队伍，以克服器官和组织再生的障碍，并将生命和物理科学的进步转化为临床医学。