Intramuscular Triglyceride in Impaired Glucose Tolerance

葡萄糖耐量受损时肌肉注射甘油三酯

• 批准号: 7391526
• 负责人: LEIGH PERREAULT
• 金额: $ 15.85万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7391526
• 关键词: Acute; Area; Arts; Attenuated; Award; Basic Science; Clinical Research; Development; Doctor of Philosophy; Educational Activities; Elements; Endocrine; Endocrinologist; Environment; Exercise; Fibrates; Foundations; Functional disorder; Gene Targeting; Goals; Insulin; Insulin Resistance; International; Internist; Intramuscular; Journals; Knowledge; Mentored Patient-Oriented Research Career Development Award; Mentors; Metabolism; Muscle; Numbers; Physicians; Research; Reservations; Schedule; Scientist; Sex Characteristics; Skeletal Muscle; Training; Triglycerides; Woman; Work; career; experience; fatty acid oxidation; impaired glucose tolerance; improved; insulin sensitivity; men; novel; peroxisome; receptor; skills; uptake

DESCRIPTION (provided by applicant): Candidate: The candidate, Leigh Perreault, MD, is a board-certified internist and endocrinologist with experience in epidemiologic, basic science, and clinical research spanning the past decade. Her most recent work examining gender differences in insulin action following acute exercise was supported by an Award from the Endocrine Fellows Foundation. This project has yielded novel and important differences which have layed the foundation for continuing research in the area exercise fuel metabolism as it pertains to insulin action. Without reservation, the most outstanding career goal is for the candidate to achieve excellence as an independent physician-scientist. The Mentored Patient-Oriented Research Career Development Award would provide the necessary training to pursue and achieve this goal. Career Development: The training plan consists of two primary elements: 1) the acquistion of an impressive number of new research skills via the local mentors as well as three scheduled apprenticeships away; and 2) educational activities, including formal classroom work, as well as attendance and participation in national meetings, local seminars and journal clubs, and one-on-one mentor interactions. Research Plan: The overall aim of the proposed project is to delineate gender differences in the development of insulin resistance in skeletal muscle. Understanding such differences would help expand our knowledge of the pathophysiology of insulin resistance itself, as well as aid in the targeting of insulin sensitizing therapy. The general hypothesis is that men and women with impaired glucose tolerance (IGT) develop insulin resistance in skeletal muscle through different mechanisms. Specifically, we hypothesize that this occurs via decreased oxidative capacity in women, and decreased action of peroxisome proliferatoractivated receptor (PPAR) alpha (and its target genes) in men. Furthermore, exercise training in women, and fibrate therapy in men, will attenuate these derangements. State-of-the-art tecnhiques will be imployed. Environment: The environment for the candidate's training is exceptional. The mentor, Robert H. Eckel, MD, is an international expert in the area of insulin action and substrate uptake and, furthermore, is a proven mentor. The co-mentor, Christopher A. DeSouza, PhD, is a rising star in academic research with expertise in exercise and substrate use. Collectively, the mentors, collaborators, and institutional commitment excels.

描述（由申请人提供）： 候选人：候选人，医学博士Leigh Perreault是一位经过董事会认证的内分学家和内分泌学家，具有过去十年的流行病学，基础科学和临床研究经验。她最近的工作在急性运动后检查了胰岛素作用的性别差异的最新工作得到了内分泌研究员基金会的一项奖项的支持。该项目产生了新颖而重要的差异，这为在该地区继续研究的基础奠定了基础，因为它与胰岛素作用有关。没有预订，最杰出的职业目标是让候选人成为独立的医师科学家。受过指导的以患者为导向的研究职业发展奖将为追求和实现这一目标提供必要的培训。 职业发展：培训计划由两个主要要素组成：1）通过当地导师以及三个计划的学徒制众多的新研究技能的获得； 2）教育活动，包括正式的课堂工作，以及参加国家会议，当地研讨会和期刊俱乐部以及一对一的导师互动。 研究计划：拟议项目的总体目的是描述骨骼肌胰岛素抵抗发展的性别差异。了解这种差异将有助于扩大我们对胰岛素抵抗本身的病理生理学的了解，并有助于靶向胰岛素敏化疗法。一般假设是，葡萄糖耐受性受损（IGT）的男性和女性通过不同的机制在骨骼肌中产生胰岛素抵抗。具体而言，我们假设这是通过女性的氧化能力降低以及过氧化物酶体增殖激活的受体（PPAR）α（及其靶基因）在男性中发生的。此外，女性运动训练和男性纤维化疗法将减轻这些危险。最先进的tecnhiques将被遗忘。环境：候选人培训的环境非常出色。导师罗伯特·H·埃克尔（Robert H.同事克里斯托弗·A·德索扎（Christopher A. Desouza）博士是具有运动和底物使用专业知识的学术研究的新星。总体而言，导师，合作者和机构承诺擅长。