Core--Research Translation

核心--研究翻译

• 批准号: 6897640
• 负责人: Keith Pezzoli
• 金额: $ 15.39万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6897640
• 关键词: bioaccumulation; biomarker; biomedical facility; biosensor device; cooperative study; detoxification; environmental health; environmental toxicology; hazardous substances; toxin metabolism

DESCRIPTION (provided by applicant): The Research Translation Core (RTC) of UCSD SBRP has four Specific Aims: 1) build partnerships with government agencies and Tribal science labs to advance the practical contributions of toxicogenomics in environmental policy and planning; 2) evaluate the utility of molecular biomarkers/biosensors, microtechnologies and bioremediation as new biological models/methods for improving environmental monitoring, risk assessment and remediation; 3) organize technology showcases, entrepreneurs/innovators forums and educational workshops to foster the commercial development and utilization of innovative SBRP technologies; and 4) communicate complex research findings to broad audiences through periodic workshops; symposia; participation in regional, national and international conferences; publications, and Web-based systems. The broad long-term objective is to apply toxicogenomic knowledge and biomolecular technologies to real-life problems concerning hazardous substances and environmental health. Along these lines, biomarkers developed by SBRP scientists will be evaluated, in partnership with the San Diego Baykeeper, Tribal labs and government agencies responsible for water quality monitoring, as potentially effective new cellular and analytic tools for detecting Superfund toxicants in contaminated watersheds. At the same time, SBRP-industry partnerships will promote the experimental development and commercialization of novel bioremediation technologies (e.g., transgenic plants that can hyper-accumulate heavy metals out of contaminated soil), and microtechnologies (e.g., labs-on-a-chip that can be used as biosensors for detecting exposure to pesticides). The RTC's approach leverages strong working partnerships and information/visualization technologies already developed by the Regional Workbench Consortium (RWBC) in partnership with the San Diego Supercomputer Center. The RWBC was established as part of the UCSD SRRP Outreach Core (2000-2005); it is a Web-based research and learning network for sustainable development. The RTC's toolkit includes on-line geographic information systems (GIS), decision support systems (DSS), multimedia interactive stories, and 3D visualization.

描述（由申请人提供）： UCSD SBRP 的研究翻译核心 (RTC) 已 四个具体目标：1）与政府机构和部落科学实验室建立伙伴关系，以推动毒物基因组学在环境政策和规划中的实际贡献； 2）评估分子生物标志物/生物传感器、微技术和生物修复作为新的生物模型/方法在改善环境监测、风险评估和修复方面的效用； 3）组织技术展示、企业家/创新者论坛和教育研讨会，以促进创新型SBRP技术的商业开发和利用； 4）通过定期研讨会向广大受众传达复杂的研究成果；研讨会；参加区域、国家和国际会议；出版物和基于网络的系统。广泛的长期目标是将毒物基因组学知识和生物分子技术应用于有关有害物质和环境健康的现实问题。 按照这些思路，SBRP 科学家开发的生物标记物将与圣地亚哥 Baykeeper、部落实验室和负责水质监测的政府机构合作进行评估，作为潜在有效的新生物标记物。 用于检测受污染流域中超级基金毒物的细胞和分析工具。 与此同时，SBRP-行业合作伙伴关系将促进新型生物修复技术（例如，可以从污染土壤中超积累重金属的转基因植物）和微技术（例如，芯片实验室）的实验开发和商业化可用作检测农药暴露的生物传感器）。 RTC 的方法利用了区域工作台联盟 (RWBC) 与圣地亚哥超级计算机中心合作开发的强大工作伙伴关系和信息/可视化技术。 RWBC 是作为 UCSD SRRP Outreach Core 的一部分而建立的（2000-2005 年）；它是一个基于网络的可持续发展研究和学习网络。 RTC 的工具包包括在线地理信息系统 (GIS)、 决策支持系统 (DSS)、多媒体互动故事和 3D 可视化。