Laboratory Training Program in Radiation Oncology

放射肿瘤学实验室培训计划

• 批准号: 7343498
• 负责人: THEODORE L DEWEESE
• 金额: $ 12.06万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7343498
• 关键词: Laboratories; Radiation Oncology; Training Programs

DESCRIPTION (provided by applicant): Radiation therapy is an important tool for the treatment of cancer patients. The evolution and optimization of this multidisciplinary approach to cancer therapy has drawn upon advances in diverse areas of cellular and molecular biology and genetics. Improvements in current treatment regimens will require research-oriented clinicians and basic scientists to explore the effects of radiation on normal and neoplastic tissues and to use new insights to devise strategies for optimizing therapy. Recent advances in these areas have provided not only considerable promise to patients but also opportunities for clinicians and scientists of the future. However, continuing advancement of this field is threatened by a critical shortage of research scientists with expertise in Radiation Oncology. As a major initiative within the newly formed Department of Radiation Oncology and Molecular Radiation Sciences (RO-MRS) at the Johns Hopkins School of Medicine, a specialized Laboratory Training Program has been designed to address this need. The RO-MRS Laboratory Training Program provides young scientists with an intensive laboratory research experience that is supplemented by broad and rigorous coursework. The goal is to impart the knowledge base and skills necessary to engage in cutting edge research, thereby positioning trainees to pursue academic careers. Trainees work in modern, newly constructed laboratories that are directed by renowned investigators who are leaders in basic and translational research. These laboratories house major, funded research programs in areas that include radiation responses of cancer cells, cancer genetics and epigenetics, DNA damage signaling, chromosome maintenance and genetic instability, apoptosis, senescence, DNA repair, novel therapeutic strategies and molecular mechanisms of therapeutic sensitivity - all areas critical to understanding and optimizing radiation therapy. Each trainee works in,an area that is specific to his/her needs and interests. Two types of trainees are supported by this program: 1) Physician scientists (MD or MD/PhD) and 2) Postdoctoral research fellows (PhD or MD/PhD). These junior scientists spend at least two, and preferably three years engaged in full time research in an area of interest directly related to contemporary Radiation Oncology. This application is for the support of two trainees each year.

描述（由申请人提供）：放射治疗是治疗癌症患者的重要工具。这种多学科方法的癌症治疗方法的进化和优化取决于细胞和分子生物学和遗传学领域的进步。当前治疗方案的改善将要求以研究为导向的临床医生和基本科学家探索辐射对正常和肿瘤组织的影响，并使用新的见解来设计以优化治疗的策略。这些领域的最新进展不仅为患者提供了巨大的希望，还为未来的临床医生和科学家提供了机会。但是，该领域的持续发展受到对辐射肿瘤学专业知识的研究科学家的严重短缺的威胁。作为新成立的辐射肿瘤学和分子辐射科学系（RO-MRS）的主要举措，约翰·霍普金斯医学院（RO-MRS）旨在满足这一需求。 RO-MRS实验室培训计划为年轻科学家提供了丰富的实验室研究经验，并补充了广泛而严格的课程。目的是授予参与尖端研究所需的知识库和技能，从而将受训者定位以从事学术职业。受训者从事现代，新建的实验室工作，这些实验室由著名的调查员指导，这些调查员是基础和转化研究领域的领导者。这些实验室主管研究计划在包括癌细胞的辐射反应，癌症遗传学和表观遗传学，DNA损伤信号传导，染色体维持和遗传不稳定性，凋亡，衰老，DNA修复，新型治疗策略和分子机制的治疗敏感性和优化敏感性 - 理解和最优化的治疗方法的所有领域。每个学员都在工作，这是针对他/她的需求和兴趣的领域。该计划支持两种类型的学员：1）医师科学家（MD或MD/PHD）和2）博士后研究研究员（PHD或PHD或MD/MD/PHD）。这些初级科学家至少花费两次，最好是在与当代辐射肿瘤学直接相关的感兴趣领域进行全日制研究。该申请每年是为了支持两名学员。