Nicotine Modulation of Ethanol Consumption and Discrimination

尼古丁对乙醇消费的调节和歧视

• 批准号: 7248316
• 负责人: MATTHEW M FORD
• 金额: $ 11.53万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-05 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7248316
• 关键词: Address; Alcohol consumption; Alcohols; Attenuated; Behavioral; Characteristics; Chemosensitization; Chronic; Complement; Condition; Cues; Data; Data Analyses; Dependence; Discrimination; Discrimination Learning; Dose; Drug Compounding; Elements; Environment; Ethanol; Evaluation; Exhibits; Exposure to; Foundations; Future; Generations; Genetic; Goals; Grant; Human; Intake; Investigation; Learning; Mentors; Methodology; Monitor; Mus; Neurobiology; Nicotine; Outcome; Pattern; Perception; Pharmaceutical Preparations; Prevalence; Principal Investigator; Procedures; Purpose; Recording of previous events; Research; Research Personnel; Research Scientist Award; Saline; Self Administration; Smoking Behavior; Solid; Solutions; Stimulus; Stimulus Generalization; Testing; Training; Translating; Work; alcohol cue; base; concept; conditioning; drug discrimination; drug of abuse; experience; insight; male; novel strategies; problem drinker; response; skills; theories

DESCRIPTION (provided by applicant): The overall goal of this Mentored Research Scientist Award (K01) application is to explore the behavioral and pharmacological ramifications of concurrent ethanol and nicotine administration while providing the candidate (Dr. Matthew Ford) with an enriched training environment and a diversified research experience that will serve to nurture his transition to an independent investigator. The candidate will complement already familiar and established self-administration procedures by working closely with the mentor/sponsor (Dr. Kathleen Grant) to establish proficiency in training drug discriminations for single drugs and drug mixtures. In addition to learning the theory behind the drug discrimination procedure, the concepts of associative blocking and overshadowing will be directly studied in relation to ethanol and nicotine interactions in the generation of a conditioned drug cue. The candidate will also become familiar with several pharmacological strategies that are commonly employed to evaluate the salience and characteristics of a discriminative drug cue, such as, generalization testing and dose-response curve assessments. The sponsor will also guide the candidate in the practice of data analysis, data interpretation and the identification of procedural limitations as specifically related to the drug discrimination procedure. The proposed studies will test specific aims that address the influence of nicotine exposure history and dose on ethanol selfadministration outcomes and evaluate the impact of nicotine on the stimulus control exhibited by an interceptive ethanol cue. This mentored training opportunity will permit the candidate to accumulate additional research skills and experience in neuropharmacological and behavioral approaches to studying alcohol and other abused drugs, and will cement a solid foundation on which to stand as an independent principal investigator. Relevance: An estimated 90% of alcoholics engage in smoking behavior. Through the investigation of concurrent nicotine and ethanol administration, this research application seeks to arrive at a more complete understanding of the functional interactions between nicotine and ethanol. This investigational approach will provide valuable insights into the prevalence of their co-abuse liability, with the added potential to identify treatment strategies for ethanol and nicotine co-dependence.

描述（由申请人提供）：这项受过指导研究科学家奖（K01）的总体目标是探索并发乙醇和尼古丁给药的行为和药理后果，同时为候选人（Matthew Ford博士）提供丰富的培训环境，并具有多元化的研究经验，以培育他向独立研究员的过渡。候选人将通过与导师/赞助商（Kathleen Grant博士）紧密合作，以建立精通培训用于单一药物和药物混合物的药物区分的熟练程度，以补充已经熟悉并建立自我管理程序。除了学习药物歧视程序背后的理论外，还将直接研究与条件药物提示的产生中的乙醇和尼古丁相互作用有关的关联阻塞和掩盖的概念。候选人还将熟悉几种通常使用的药理学策略，这些策略通常用于评估歧视性药物提示的显着性和特征，例如概括测试和剂量反应曲线评估。赞助商还将指导候选人在数据分析，数据解释和识别与药物歧视程序特别相关的程序限制的实践中。拟议的研究将测试特定的目的，以解决尼古丁暴露史和剂量对乙醇自我施用结果的影响，并评估尼古丁对互感乙醇提示所表现出的刺激控制的影响。这一受过指导的培训机会将使候选人能够积累其他研究技能和在研究酒精和其他滥用药物的神经药理学和行为方法方面的经验，并将巩固作为独立首席研究员的坚实基础。相关性：估计有90％的酗酒者从事吸烟行为。通过调查并发的尼古丁和乙醇给药，该研究应用程序试图对尼古丁和乙醇之间的功能相互作用有更全面的了解。这种研究方法将为其共同滥用责任的普遍性提供宝贵的见解，并具有较大的潜力来识别乙醇和尼古丁共同依赖性的治疗策略。