In-Vivo Micro computed Tomography system

体内微型计算机断层扫描系统

• 批准号: 6876930
• 负责人: Steven A Goldstein
• 金额: $ 27.9万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-01 至 2006-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6876930
• 关键词: bioimaging /biomedical imaging; biomedical equipment purchase; computed axial tomography; digital imaging; morphology; three dimensional imaging /topography

DESCRIPTION (provided by applicant): The objective of this proposal is to purchase an in-vivo three-dimensional micro computed tomography scanner. The system has the capability of digitizing the three-dimensional morphology and in some cases micro-architecture of anatomic structures (dominantly skeletal) in-vivo, at a resolution between 45 and 75 microns. This system will functionally be operated as a Core technology within the Musculoskeletal Core Research Center at the University of Michigan. The principle rationale for the purchase of this new system is based on the demonstrated need for longitudinal measures of tissue or organ morphology in small animal models. The data that can be acquired by the in vivo 3D MicroCT system enables investigators to study mechanisms associated with skeletal diseases ranging from osteoporosis to osteogenesis imperfecta and evaluating the discovery and development of therapeutics including tissue engineered constructs.

描述（由申请人提供）：本提案的目的是购买一台体内三维微型计算机断层扫描仪。该系统能够以 45 至 75 微米的分辨率对三维形态进行数字化，在某些情况下还能够对体内解剖结构（主要是骨骼）的微结构进行数字化。该系统将在密歇根大学肌肉骨骼核心研究中心内作为核心技术运行。购买这个新系统的主要理由是基于对小动物模型中组织或器官形态的纵向测量的需求。体内 3D MicroCT 系统可以获得的数据使研究人员能够研究与骨骼疾病（从骨质疏松症到成骨不全症）相关的机制，并评估包括组织工程结构在内的治疗方法的发现和开发。