Acquisition of a Small Animal CT Scanner

购置小动物 CT 扫描仪

• 批准号: 6580702
• 负责人: RICHARD Andre LAFOREST
• 金额: $ 39.42万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-01 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6580702
• 关键词: bioimaging /biomedical imaging; biomedical equipment purchase; computed axial tomography

DESCRIPTION (provided by applicant): Small animal imaging has become a powerful tool for drug development and for the understanding of diseases. With animal models widely used in basic and pre-clinical sciences, finding ways to conduct animal experiments more accurately and efficiently is now a key factor in the success and timeliness of research. The recent evolution in molecular biology and genomics has created a large demand for transgenic laboratory animals. In oncology, the use of radiopharmaceuticals for the non-invasive diagnosis of cancer has long been established. And now, small animal PET imaging is being used extensively for tumor targeting by the use of metabolic, transport and receptor-mediated processes to deliver the imaging agent for cancer diagnostic in tumor bearing small animal. The use of high resolution microCT images will augment the performance of functional imaging currently obtained with our microPET by providing accurate identification and localization of normal organ or tumor volume. The combined technologies will allow for the study of disease progression in longitudinal studies and response to therapy over time. Other applications, including pulmonary, cardiology, immunology and orthopedic surgery will all benefit from higher resolution anatomical information. These images will also be used to improve the quality of functional images by providing an accurate attenuation correction. This proposal from Washington University, School of Medicine, is to request funds for the purchase of a 40 micron spatial resolution small animal X-ray CT camera. This instrument will be made available to researchers of many disciplines at Washington University.

描述（由申请人提供）： 小动物成像已成为药物开发和了解疾病的强大工具。随着动物模型在基础科学和临床前科学中的广泛应用，寻找更准确、更高效地进行动物实验的方法现已成为研究成功和及时性的关键因素。分子生物学和基因组学的最新发展创造了对转基因实验动物的巨大需求。在肿瘤学中，使用放射性药物进行癌症的非侵入性诊断早已确立。现在，小动物 PET 成像已广泛用于肿瘤靶向，通过使用代谢、运输和受体介导的过程来递送显像剂，用于对携带肿瘤的小动物进行癌症诊断。高分辨率 microCT 图像的使用将通过提供正常器官或肿瘤体积的准确识别和定位来增强目前使用 microPET 获得的功能成像的性能。组合技术将允许纵向研究疾病进展以及随着时间的推移对治疗的反应。其他应用，包括肺科、心脏病学、免疫学和骨科手术都将受益于更高分辨率的解剖信息。这些图像还将用于通过提供精确的衰减校正来提高功能图像的质量。华盛顿大学医学院的这项提案是请求资金购买一台40微米空间分辨率的小动物X射线CT相机。该仪器将提供给华盛顿大学许多学科的研究人员。