A NOVEL ANALOGUE BIO-IMPEDANCE SYSTEM-ON-A-CHIP FOR MONITORING OF NEONATE LUNG FUNCTION

用于监测新生儿肺功能的新型模拟生物阻抗片上系统

• 批准号: EP/E031633/1
• 负责人: Richard Bayford
• 金额: $ 22.44万
• 依托单位: Middlesex University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FE031633%2F1
• 关键词: NOVEL; ANALOGUE; BIO; IMPEDANCE; SYSTEM

This research proposes the development of an urgently needed Electrical Impedance Tomography (EIT)-based bio-imaging system for in-vivo monitoring of neonate lung function in Intensive care Units (ITUs). Disorders of lung growth, maturation and breathing control are among the most important problems faced by the neonatologist. Premature birth occurs in 5-10% of all pregnancies, and is frequently accompanied by complications due to lung immaturity. The annual cost to the NHS is estimated in the order of hundreds of millions. One of the key difficulties of neonate ITU monitoring for lung function is that the system must measure the subject in a passive manner, unlike adults who can be asked to perform specific respiratory tasks. EIT is the only solution to this problem. Moreover, EIT is proving to be successful in many clinical applications, an example is the new commercial TSCAN system for detection of breast cancer.The proposed system will provide a non-invasive measure of lung maturity and development, oxygen requirements and lung function, suitable for use in small, unsedated infants. This tool will be routinely used to define the nature and severity of persisting lung disease, and to identify risk factors for developing chronic lung problems. Major limitations of EIT are the inherent common mode errors which result in reduction of the quality of the reconstructed images. These errors are more pronounced in the case of multi-frequency EIT. We have invented a method to address the problem by the use of a novel wideband analogue common-mode enhancement technique which can maximise the overall common-mode rejection ratio (CMRR) and signal-to-noise ratio (SNR). To take full advantage of the capabilities of our wideband CMRR feedback approach, we will use full custom circuit design techniques to create a novel multi-frequency EIT system-on-a-silicon-chip. We have also developed advanced reconstruction methods involving new mesh warping techniques that utilise the boundary information to condition the forward model, taking into account the anatomical details of the problem domain. The end result of this research will be new technology in the form of a wearable device which will minimise disruption when monitoring neonates. This will involve the design of custom made silicon chips, an integrated wearable electrode system, new 3D image reconstruction algorithms and advanced post image processing methodologies. This research will be carried out with the full clinical support of the Portex Anaesthesia, Intensive Therapy and Respiratory Medicine Unit at the world leading children's Hospital, Great Ormond Street, London.

这项研究建议开发急需的电阻抗层析成像（EIT）基于基于重症监护病房（ITU）新生肺功能的基于基于的生物成像系统。肺部生长，成熟和呼吸控制的疾病是新生儿学家面临的最重要问题之一。过早出生发生在所有妊娠的5-10％，并且经常伴有肺部不成熟引起的并发症。 NHS的年度成本按数亿美元的顺序估计。新生儿ITU对肺功能的监测的主要困难之一是，该系统必须以被动的方式衡量受试者，这与可以要求执行特定呼吸任务的成年人不同。 EIT是解决此问题的唯一解决方案。此外，EIT在许多临床应用中已被证明是成功的，一个例子是用于检测乳腺癌的新商业TSCAN系统。拟议的系统将提供无创的肺部成熟度和发育，氧气需求和肺功能，适用于小型，未培养的婴儿。该工具将通常用于定义持续性肺部疾病的性质和严重性，并确定出现慢性肺部问题的危险因素。 EIT的主要局限性是固有的常见模式错误，导致降低重建图像的质量。在多频性EIT的情况下，这些错误更为明显。我们通过使用新型的宽带类似物共同模式增强技术来解决问题，该方法可以最大化总体公共模式排斥比（CMRR）和信噪比（SNR）。为了充分利用宽带CMRR反馈方法的功能，我们将使用完整的自定义电路设计技术来创建一种新颖的多频EIT EIT系统，即塞利康芯片。我们还开发了涉及新的网格翘曲技术的高级重建方法，这些方法利用边界信息来调节正向模型，并考虑到问题域的解剖学细节。这项研究的最终结果将是可穿戴设备的形式的新技术，该技术将在监测新生儿时最大程度地减少干扰。这将涉及定制硅芯片的设计，一种集成的可穿戴电极系统，新的3D图像重建算法和高级后图像处理方法。这项研究将在伦敦大奥蒙德街的世界领先儿童医院的Portex麻醉，强化疗法和呼吸医学部门的全部临床支持下进行。