PNEUMACRIT: Preterm Neonate / neonatal Embedded Universal Microelectronic wearable Acquisition For Cardio Respiratory Intensive Therapy

PNEUMACRIT：早产新生儿/新生儿嵌入式通用微电子可穿戴采集设备，用于心肺强化治疗

基本信息

批准号：
EP/T001240/1
负责人：
Richard Bayford
金额：
$ 100.09万
依托单位：
Middlesex University
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2020
资助国家：
英国
起止时间：
2020 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=EP%2FT001240%2F1
关键词：
PNEUMACRIT Preterm Neonate neonatal Embedded

项目摘要

PNEUMACRIT will provide a revolutionary multi sensor wearable imaging system that will inform lung function diagnosis for infants and children with conditions that can lead to respiratory problems. Although respiratory support, especially mechanical ventilation, can improve their survival, it may also cause severe injury to the vulnerable lungs, resulting in chronic pulmonary morbidity lasting into adulthood. PNEUMACRIT has the potential to provide early detection of respiratory failure in infants, by providing a low-cost monitoring system, which will also facilitate optimisation of the respiratory support. This will provide both immediate benefits and decrease the risk of patients developing long-term respiratory disorders. PNEUMACRIT pursues breakthroughs in analytical measurement, microsystems embedded in flexible printable wearable materials, signal processing, and organic devices, to produce multi-parameter clinical measurements obtained from the data produced from electrical impedance tomography (EIT), Electrocardiogram (ECG) and apnoea monitoring. EIT is a non-radiative, inexpensive technique that uses small electrical currents to produce cross sectional images of the body that can facilitate real time dynamic monitoring of lung aeration, and recent studies have shown that it is effective in monitoring aeration in preterm babies in a clinical setting. However, to maximise its diagnostics potential, this EIT information need to be combined with other non-invasive measures. Advances in electrode technologies within the project will enable multi-site recordings, without the need for physical interconnection and integrated power supplies, opening the door to a new generation of diagnostic wearables. Such monitoring is crucial because each year millions of babies across the world suffer from respiratory failure due to immaturity of the lung or infectious diseases. In addition, standard lung function tests are not suitable for use with babies and young children until they are old enough to actively co-operate with instructions (~age 7 years). Therefore, PNEMACRIT could, in future, provide valuable lung function information to this age group as well.

Pneumacrit将提供革命性的多传感器可穿戴成像系统，该系统将为婴儿和儿童提供可能导致呼吸系统疾病的儿童的肺功能诊断。尽管呼吸支持，尤其是机械通气，可以提高其存活率，但也可能对脆弱的肺部造成严重伤害，导致慢性肺部发病率一直持续到成年。通过提供低成本监测系统，肺炎有潜力可以尽早发现婴儿呼吸衰竭，这也将促进优化呼吸支持。这将提供直接的益处，并降低患者患有长期呼吸系统疾病的风险。肺炎在分析测量中追求突破性，嵌入在可打印的可穿戴材料中的微型系统，信号处理和有机设备，以生成从电力造影术（EIT），电压（ECG）和APNEA监视的数据中获得的多参数临床测量结果。 EIT是一种非辐射，廉价的技术，它使用小型电流来产生人体的横截面图像，可促进肺气充气的实时动态监测，并且最近的研究表明，它在临床环境中的早产婴儿中有效监测了曝气。但是，为了最大程度地发挥其诊断潜力，此EIT信息需要与其他非侵入性措施相结合。项目内电极技术的进步将使多站点录音无需物理互连和集成电源，为新一代诊断可穿戴设备打开了大门。这种监测至关重要，因为每年，全世界数以百万计的婴儿由于肺部或传染病的不成熟而遭受呼吸衰竭。此外，标准的肺功能测试不适合与婴儿和幼儿一起使用，直到它们年纪大到可以通过指示积极合作（〜7岁）。因此，将来Pnemacrit也可以为该年龄段提供有价值的肺功能信息。

项目成果

期刊论文数量（9）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Cross-sectional chest circumference and shape development in infants.

DOI：
10.1186/s13104-022-06087-z
发表时间：
2022-06-15
期刊：
BMC research notes
影响因子：
1.8
作者：
通讯作者：

Thoracic shape changes in newborns due to their position.

DOI：
10.1038/s41598-021-83869-8
发表时间：
2021-02-24
期刊：
Scientific reports
影响因子：
4.6
作者：
de Gelidi S;Bardill A;Seifnaraghi N;Wu Y;Demosthenous A;Rahtu M;Kallio M;Bayford R
通讯作者：
Bayford R

Bronchodilator effect on regional lung function in pediatric viral lower respiratory tract infections.

支气管扩张剂对小儿病毒性下呼吸道感染局部肺功能的影响。