Design, construction, and evaluation of implants for vocal fold alteration and re

声带改造和再造植入物的设计、构建和评估

• 批准号: 7584706
• 负责人: LUC MONGEAU
• 金额: $ 34.7万
• 依托单位: MCGILL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7584706
• 关键词: Adhesions; Air; Atomic Force Microscopy; Atrophic; Beds; Behavior; Biocompatible Materials; Biological; Biomechanics; Biomedical Engineering; Canis familiaris; Cell physiology; Characteristics; Cicatrix; Classification; Clinical; Collagen; Computer-Aided Design; Condition; Data; Dependence; Development; Diffusion; Endoscopes; Engineering; Ensure; Evaluation; Fascia; Fatty acid glycerol esters; Frequencies; Gestures; Glare; Goretex; Grant; Human; Hyaluronic Acid; Hydroxyapatites; Implant; In Vitro; Injection of therapeutic agent; Invasive; Knowledge; Laboratories; Lamina Propria; Larynx; Laser-Doppler Velocimetry; Materials Testing; Measurement; Measures; Mechanics; Methods; Modeling; Object Attachment; Operative Surgical Procedures; Pathology; Pattern; Phonation; Production; Property; Prostheses and Implants; Prosthesis; Proteins; Public Health; Rate; Relative (related person); Research; Resolution; Rest; Silicones; Source; Stress; Surface; Surface Properties; System; Testing; Tissue Model; Tissues; Voice; Voice Disorders; Voice Quality; Work; design; design and construction; digital imaging; engineering design; human data; human subject; implantation; nanoscale; pressure; programs; reconstruction; repaired; response; scaffold; sound; tool; vibration; vocal cord; vocalis muscle

DESCRIPTION (provided by applicant): The broad objective of the proposed studies is to apply design, dynamic testing, and material testing methods from Mechanical Engineering to better understand the impact of existing and new vocal fold implants and prostheses for vocal fold medialization, partial or total lamina propria reconstruction on the mechanical properties and dynamic response of native laryngeal tissue and, ultimately, voice quality. It is postulated that the systematic application of the proposed methods will eventually help the creation of implants and prostheses with mechanical behavior representative of native tissue that are robust and durable. Much work has been done on the use of vocal fold implants and prostheses for the surgical repair of vocal pathologies involving the lamina propria, such as scarring, sulcus vocalis, and atrophy, which remain challenging clinical problems in laryngology and phonosurgery. Biomaterials used have included specific types of fat, collagen, hyaluronic acid, fascia, and a variety of synthetic materials such as silicone, Gore-Tex, or hydroxyapatite. Previous work has been done without a detailed knowledge of the mechanical properties and response of the synthetic or biological materials used. This may have resulted in sub-optimal oscillatory function, and reduced voice quality. The present study aims at developing and evaluating synthetic models, implants, and prostheses with a set of mechanical properties that closely match measured data for human vocal fold tissue. Synthetic models of the larynx will be perfected and used for fundamental studies, as well as test beds for new implants. Digital image correlation methods will be developed in order to obtain dynamic, full field strain data and stress estimates that will help quantify the influence of prosthesis and implants on mechanical response. The dependence of the vocal folds resonance frequencies on tension, air flow rate, and implant design will be quantified. The influence of selected matrix proteins on the viscoelastic properties of the lamina propria will be measured in order to better under the consequences of the biological response of the tissue to foreign inclusions. The issues of bonding between implants and native tissue will be examined using atomic force microscopy. PUBLIC HEALTH RELEVANCE The basic studies and developing models of this research program are intended to develop tools that will aid the clinical and surgical treatment of voice disorders.

描述（由申请人提供）：拟议研究的广泛目标是应用设计，动态测试和从机械工程的材料测试方法，以更好地了解现有和新的声折叠植入物和假体对声音折叠，部分或全层层次的层次或总体层层次的层次重构对机械属性和动态laryngeal and laryngeal组织和动态响应的影响。据推测，所提出的方法的系统应用最终将有助于建立植入物和假体，并具有机械行为的代表天然组织的机械行为，这些组织是坚固耐用的。关于使用声带植入物和假体进行了许多工作，用于修复涉及固有椎板的人声病理学，例如疤痕，嗓音和萎缩，这些疾病仍然在喉部和语音外疾病方面具有挑战性的临床问题。使用的生物材料包括特定类型的脂肪，胶原蛋白，透明质酸，筋膜和各种合成材料，例如有机硅，戈尔 - 特克斯或羟基磷灰石。先前的工作已经完成，没有详细了解所使用的合成或生物材料的机械性能和响应。这可能导致了优化的振荡功能，并降低了语音质量。本研究旨在开发和评估具有一组机械性能的合成模型，植入物和假体，这些特性与人声折叠组织的测量数据紧密匹配。喉的合成模型将被完善并用于基本研究，以及新植入物的测试床。将开发数字图像相关方法，以获取动态，完整的现场应变数据和应力估计，这将有助于量化假体和植入物对机械响应的影响。人声褶皱共振频率对张力，空气流量和植入物设计的依赖性将被量化。将测量选定基质蛋白对固有层的粘弹性特性的影响，以便在组织对异物夹杂物的生物学反应的后果下更好地测量。将使用原子力显微镜检查植入物与天然组织之间的粘结问题。公共卫生相关性的基础研究和开发该研究计划的模型旨在开发有助于语音疾病的临床和外科手术治疗的工具。