Fluid Structure Interactions Within the Human Larynx

人喉内的流体结构相互作用

• 批准号: 6686463
• 负责人: LUC MONGEAU
• 金额: $ 57.38万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6686463
• 关键词: biomechanics; computer program /software; computer simulation; digital imaging; fluid flow; larynx; mathematical model; model design /development; physical model; shear stress; sound; tissue support frame; vibration; viscosity; vocal cords; voice

DESCRIPTION (provided by applicant): This proposal describes a study of fluid-structure interaction phenomena within the human larynx during phonation. The motion of the vocal folds is driven in part by the aerodynamic pressure on their surfaces. During phonation, there is a periodic exchange of energy between the elastic deformation of the vocal folds and the surface pressures associated with the airflow through the larynx. A good understanding of the associated fluid-structure interaction mechanisms is of utmost importance in order to develop accurate predictive models of phonatory processes, and accurate estimates of the stresses within the tissue. The purpose of the proposed research is to gain a thorough understanding of the mechanics of fluid-induced oscillations of the laryngeal tissue, including aspects related to the possible role of the false vocal folds in phonation. The aims are to: 1) perform detailed flow, kinematic, and sound measurements using a self oscillating physical model of the larynx and the false vocal folds; 2) develop detailed and accurate computational models as well as approximate reduced order models for the prediction of fluid flow, radiated sound, and tissue deformation of the larynx and false folds; and 3) determine the effects on laryngeal dynamics of normal and pathological conditions of the larynx, and clarify the role of the false vocal folds. Fundamental phonation processes will be isolated and studied. The different theoretical and physical models will be used to cross-validate new information that bridges from idealized models and real larynx phonation. Comparisons will be made between data obtained using the physical models and the numerical predictions. This will allow the validation of the numerical models, and reinforce our understanding of the physical phenomena involved. The overarching goal is to develop accurate computer prediction models of voice production that may eventually be useful for making precise diagnostic decisions in the voice clinic, targeting optimal intervention strategies for voice problems, and achieving high quality articulatory speech synthesis. Accurate stress calculations are also needed and useful for tissue damage predictions. This research program is a collaboration among laboratories at Bowling Green State University and Purdue University.

描述（由申请人提供）：该提案描述了对人喉体中流体结构相互作用现象的研究。声带的运动部分是由于其表面上的空气动力压力驱动的。在发音过程中，在声带的弹性变形与通过喉部的气流相关的表面压力之间会定期交换能量。对相关的流体结构相互作用机制的良好理解对于开发语音过程的准确预测模型以及对组织内的应力的准确估计至关重要。拟议的研究的目的是对流体诱导的喉组织振荡的力学有透彻的理解，包括与虚假声音在发声中可能作用有关的方面。目的是：1）使用喉部的自我振荡物理模型和错误的声带进行详细的流动，运动学和声音测量； 2）开发详细而准确的计算模型，以及近似降低的阶数模型，以预测流体流动，辐射声和喉部和假褶皱的组织变形； 3）确定对喉部正常和病理条件的喉动力学的影响，并阐明虚假声带的作用。基本发声过程将被隔离和研究。不同的理论和物理模型将用于交叉估算新的信息，这些信息桥梁从理想化的模型和真实的喉部发音中桥梁。将在使用物理模型获得的数据和数值预测获得的数据之间进行比较。这将允许验证数值模型，并增强我们对所涉及的物理现象的理解。总体目标是开发精确的语音生产计算机预测模型，该模型最终可能有助于在语音诊所做出精确的诊断决策，针对语音问题的最佳干预策略，并实现高质量的发音语音综合。还需要准确的应力计算，对于组织损伤预测有用。该研究计划是鲍灵格林州立大学和普渡大学实验室之间的合作。