Neural mechanisms of auditory feedback during speech

言语过程中听觉反馈的神经机制

• 批准号: 7455196
• 负责人: SRIKANTAN S. NAGARAJAN
• 金额: $ 46.23万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-15 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7455196
• 关键词: Acoustics; Affect; Area; Attenuated; Auditory; Auditory Perception; Auditory area; Behavioral; Brain Part; Clinical; Condition; Data; Discrimination; Early Diagnosis; Elements; Esthesia; Exposure to; Feedback; Frequencies; Functional Magnetic Resonance Imaging; Generations; Image; Impairment; Knowledge; Lead; Location; Magnetism; Methods; Modeling; Motor; Motor output; Movement; Numbers; Output; Parkinson Disease; Perception; Phonetics; Process; Production; Reporting; Research Personnel; Resolution; Schizophrenia; Signal Transduction; Source; Speech; Speech Perception; Speech Sound; Stimulus; Stuttering; Testing; Time; Update; Work; attenuation; auditory discrimination; auditory feedback; base; gain of function; insight; motor control; neuroimaging; neuromechanism; preference; programs; reconstruction; relating to nervous system; research study; response; speech processing

DESCRIPTION (provided by applicant): Understanding how auditory feedback is processed during speaking provides insights into fundamental mechanisms underlying speech production and perception. This knowledge might also ultimately contribute to the early detection and lead to treatment strategies for a number of prevalent clinical conditions where impairments in abnormal processing of auditory feedback have been reported (e.g. stuttering, Parkinson's disease, schizophrenia). While many behavioral studies have examined how auditory perception affects speech production, only recently have functional neuroimaging studies begun examining how producing speech affects the neural processes serving auditory perception. Recent studies have shown that in auditory cortex and other areas in the superior temporal plane, speaking causes "speaking-induced suppression" (SIS): response to self-produced speech is suppressed when compared to identical speech from an external source. In our recent work, we have shown that SIS in auditory cortex does not result from overall inhibition of this area during speaking. Rather, SIS appears to be a neural correlate of a feedback prediction error (FPE) - a comparison between actual auditory input and an internal "speaking-induced prediction" (SIP) of that auditory input. SIS expression in auditory cortex has led to the hypothesis that SIS reflects auditory discrimination of self-produced from externally produced stimuli (Self-non-Self Hypothesis). However, refinements in our understanding of auditory feedback in speech motor control, that are supported by behavioral studies and our preliminary data, suggest that SIS may also reflect feedback processing for speech motor control (Speech Motor Control Hypothesis). We have developed a unifying conceptual model that embodies both hypotheses, and our proposed experiments use SIS to test the neural correlates and the validity of this model. The specific aims are to determine how SIS is modulated by 1) altered feedback, 2) speech target dynamics and 3) speech motor adaptation. These manipulations not only help us to unravel the functional significance of SIS but also help us determine if there is a differentiation of the function of SIS across the superior temporal plane. Furthermore, how activity in other parts of the brain is affected by our experimental manipulations will allow us to determine the neural correlates of the mechanisms that generate SIS. Our approach capitalizes on unique real-time speech feedback alteration methods used with functional magnetic resonance imaging (fMRI) and magnetic source imaging (MSI). The excellent spatial resolution of fMRI will enable reconstruction of spatial locations of activity related to SIS and SIP while the excellent temporal resolution of MSI will enable us to reconstruct the sequence of activation in these areas.

描述（由申请人提供）：了解在说话期间如何处理听觉反馈提供了对语音生产和感知基本机制的见解。这些知识也可能最终有助于早期发现，并导致许多普遍的临床状况的治疗策略，在这些临床状况中，已经报道了听觉反馈异常处理的损害（例如口吃，帕金森氏病，精神分裂症）。尽管许多行为研究研究了听觉感知如何影响语音产生，但直到最近才进行了功能性神经影像学研究，才开始研究产生言语如何影响听觉感知的神经过程。最近的研究表明，在上级颞平面的听觉皮层和其他区域中，与来自外部来源的相同语音相比，抑制了“口语诱导的抑制”（SIS）：对自我产生的语音的反应受到抑制。在我们最近的工作中，我们证明了听觉皮层中的SIS并不是由于在讲话过程中对该领域的总体抑制作用而引起的。相反，SIS似乎是反馈预测错误（FPE）的神经相关性 - 实际听觉输入与该听觉输入的内部“语言诱导的预测”（SIP）之间的比较。听觉皮层中的SIS表达导致了以下假设：SIS反映了从外部产生的刺激（自称为自我假设）中自我产生的听觉歧视。但是，在我们对语音运动控制中听觉反馈的理解中得到了改进，这些反馈得到了行为研究和我们的初步数据的支持，这表明SIS也可能反映了语音运动控制的反馈处理（语音运动控制假设）。我们已经开发了一个统一的概念模型，可以体现两个假设，我们提出的实验使用SIS测试该模型的神经相关性和有效性。具体的目的是确定SIS如何通过1）改变反馈，2）语音目标动力学和3）语音运动适应。这些操作不仅有助于我们阐明SI的功能意义，而且还可以帮助我们确定SIS在上级颞平面上的功能是否存在差异。此外，大脑其他部位的活性如何受我们的实验操作的影响将使我们能够确定产生SIS的机制的神经相关性。我们的方法利用了与功能磁共振成像（fMRI）和磁源成像（MSI）一起使用的独特实时语音反馈改变方法。 fMRI的出色空间分辨率将能够重建与SIS和SIP相关的活动的空间位置，而MSI的出色时间分辨率将使我们能够重建这些区域中激活的序列。

项目成果

Residual coherence and residual envelope correlation in MEG/EEG source-space connectivity analysis.

• DOI: 10.1109/embc.2013.6610525
• 发表时间: 2013
• 期刊: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
• 作者: Sekihara K;Nagarajan SS
• 通讯作者: Nagarajan SS

The structural connectome of the human brain in agenesis of the corpus callosum.

• DOI: 10.1016/j.neuroimage.2012.12.031
• 发表时间: 2013-04-15
• 期刊: NeuroImage
• 影响因子: 5.7
• 作者: Owen JP;Li YO;Ziv E;Strominger Z;Gold J;Bukhpun P;Wakahiro M;Friedman EJ;Sherr EH;Mukherjee P
• 通讯作者: Mukherjee P

Speech production as state feedback control.

• DOI: 10.3389/fnhum.2011.00082
• 发表时间: 2011
• 期刊: Frontiers in human neuroscience
• 影响因子: 2.9
• 作者: Houde JF;Nagarajan SS
• 通讯作者: Nagarajan SS