Stress, Sleep and Emerging CVD Risk Factors

压力、睡眠和新出现的心血管疾病危险因素

• 批准号: 7257078
• 负责人: KAREN MATTHEWS
• 金额: $ 56.83万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7257078
• 关键词: Acute; Address; Adverse effects; African American; Age; Ambulatory Blood Pressure Monitoring; Apnea; Arteries; Blood Pressure; C-reactive protein; Caliber; Cardiac; Cardiology; Cardiovascular Diseases; Cardiovascular system; Catecholamines; Caucasians; Caucasoid Race; Cessation of life; Characteristics; Cholesterol; Chronic; Collection; Coronary; Coronary heart disease; Data; Disease; Electroencephalography; Elevation; Equation; Evaluation; Event; Fibrinogen; Frequencies; Funding; Gender; Goals; Grant; Heart; Home environment; Hospitalization; Hour; Hydrocortisone; Hyperglycemia; Hypertension; Individual; Inflammatory; Interleukin-6; Intervention; Kidney Failure; Label; Lead; Life; Link; Measures; Mediating; Metabolic syndrome; Modeling; Morbidity - disease rate; Myocardial Infarction; Oxygen; Participant; Patient Self-Report; Pennsylvania; Physiological; Physiology; Polysomnography; Population; Prevention program; Procedures; Psychophysiology; Psychosocial Stress; Race; Recording of previous events; Relative (related person); Resources; Risk; Risk Factors; Role; Sampling; Score; Sleep; Sleep Apnea Syndromes; Sleep disturbances; Smoking; Stress; Stressful Event; Stroke; Testing; Thinking; Time; Unstable angina; Urine; Wrist; base; brachial artery; calcification; cardiovascular disorder risk; cardiovascular risk factor; cigarette smoking; coronary artery calcification; cost; design; indexing; interest; mortality; novel; pressure; success; urinary

DESCRIPTION (provided by applicant): Growing evidence suggests that cardiovascular disease (CVD) morbidity and mortality may be predicted not only by established risk factors such as cholesterol level, hypertension, cigarette smoking, and hyperglycemia, but also by a set of emerging risk factors. These include the inflammatory markers, C reactive protein and interleukin 6, metabolic syndrome, and mild renal insufficiency. A project called HeartSCORE funded by the Commonwealth of Pennsylvania (Steven Reis, PI) is evaluating these emerging risk factors as well as coronary calcification, and brachial artery diameter in a population-based sample of 1000 African Americans and 1000 Caucasians. Our proposed project will build on this invaluable resource by examining another set of novel risk factors for CVD thought to be upstream from the more proximal, emerging risk factors: sleep disordered breathing (SDB) and psychosocial stress. Our project will evaluate whether links of both SDB and psychosocial stress with CVD risk may be due to their effects on nocturnal physiology, namely altered nonSDB sleep characteristics, nighttime elevation in blood pressure relative to daytime BP (termed nondipping), elevated urinary catecholamines and cortisol, and impaired autonomic tone. Thus, the general aim of this study is to understand the nocturnal psychophysiological underpinnings of cardiovascular morbidity and mortality. To address this general aim, we will study a multi-ethnic sample of 225 individuals drawn from two of the groups in the larger HeartSCORE design: (1) those who have high/moderate (hereafter labeled high) or (2) low Framingham risk equation scores, with no history of stroke, myocardial infarction, or interventional cardiology procedures in either group. The two groups will be matched on gender, race, and age. The proposed study will include two nights of polysomnography (PSG) conducted in participants' homes, two 24-hour periods of ambulatory blood pressure (ABP) monitoring, overnight urine collections on PSG night 2 and ABP night 2, wrist actigraghy on 10 nights, and assessment of self-report and other physiological indices. The study will provide novel data testing the relationships of daytime stressful events, SDB, and other nocturnal physiological measures with the emerging risk factors and subclinical CVD measured in HeartSCORE.

描述（由申请人提供）：越来越多的证据表明，心血管疾病（CVD）的发病率和死亡率不仅可以通过胆固醇水平、高血压、吸烟和高血糖等既定风险因素来预测，还可以通过一系列新出现的风险因素来预测。这些包括炎症标志物、C 反应蛋白和白细胞介素 6、代谢综合征和轻度肾功能不全。由宾夕法尼亚州 (Steven Reis, PI) 资助的一个名为 HeartSCORE 的项目正在以 1000 名非裔美国人和 1000 名白种人为基础的人口样本中评估这些新出现的危险因素以及冠状动脉钙化和肱动脉直径。我们提出的项目将建立在这一宝贵资源的基础上，通过检查另一组新的 CVD 风险因素，这些因素被认为是更近端的新兴风险因素的上游：睡眠呼吸障碍 (SDB) 和社会心理压力。我们的项目将评估 SDB 和心理社会压力与 CVD 风险之间的联系是否可能是由于它们对夜间生理的影响，即非 SDB 睡眠特征的改变、夜间血压相对于白天血压的升高（称为非下降）、尿儿茶酚胺和皮质醇升高和自主神经张力受损。因此，本研究的总体目的是了解心血管发病率和死亡率的夜间心理生理基础。为了实现这一总体目标，我们将研究从较大 HeartSCORE 设计中的两个群体中抽取的 225 名个体的多种族样本：(1) 具有高/中度（以下标记为高）或 (2) 低 Framingham 风险的人方程评分，两组均无中风、心肌梗塞或介入心脏病学病史。两组将在性别、种族和年龄上进行匹配。拟议的研究将包括在参与者家中进行两个晚上的多导睡眠图 (PSG)、两个 24 小时动态血压 (ABP) 监测、PSG 第 2 个晚上和 ABP 第 2 个晚上的夜间尿液收集、10 个晚上的腕部活动监测、自我报告和其他生理指标的评估。该研究将提供新的数据来测试日间压力事件、SDB 和其他夜间生理指标与 HeartSCORE 中测量的新出现的危险因素和亚临床 CVD 之间的关系。

项目成果

Blood pressure dipping and sleep disturbance in African-American and Caucasian men and women.

非裔美国人和白人男性和女性的血压下降和睡眠障碍。

• 发表时间: 2008-07
• 影响因子: 3.2
• 作者: Matthews, Karen A;Kamarck, Thomas W;H Hall, Martica;Strollo, Patrick J;Owens, Jane F;Buysse, Daniel J;Lee, Laisze;Reis, Steven E
• 通讯作者: Reis, Steven E

African Genetic Ancestry is Associated with Sleep Depth in Older African Americans.

非洲遗传血统与老年非裔美国人的睡眠深度有关。

• 发表时间: 2015-08-01
• 影响因子: 5.6
• 作者: Halder, Indrani;Matthews, Karen A;Buysse, Daniel J;Strollo, Patrick J;Causer, Victoria;Reis, Steven E;Hall, Martica H
• 通讯作者: Hall, Martica H

Napping, nighttime sleep, and cardiovascular risk factors in mid-life adults.

中年成年人的午睡、夜间睡眠和心血管危险因素。

• DOI: 10.5664/jcsm.27873
• 发表时间: 2010-08-15
• 期刊: Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
• 作者: J. Owens;Daniel J Buysse;M. Hall;T. Kamarck;Laisze Lee;P. Strollo;S. Reis;K. Matthews
• 通讯作者: K. Matthews

Sleep apnea is related to the atherogenic phenotype, lipoprotein subclass B.

睡眠呼吸暂停与致动脉粥样硬化表型、脂蛋白 B 亚类有关。

• 发表时间: 2012-04-15
• 作者: Luyster, Faith S;Kip, Kevin E;Drumheller, Oliver J;Rice, Thomas B;Edmundowicz, Daniel;Matthews, Karen;Reis, Steven E;Strollo Jr, Patrick J
• 通讯作者: Strollo Jr, Patrick J

Social integration, social contacts, and blood pressure dipping in African-Americans and whites.

非裔美国人和白人的社会融合、社会交往和血压下降。

• 发表时间: 2010-02
• 影响因子: 4.9
• 作者: Troxel, Wendy M;Buysse, Daniel J;Hall, Martica;Kamarck, Thomas W;Strollo, Patrick J;Owens, Jane F;Reis, Steven E;Matthews, Karen A
• 通讯作者: Matthews, Karen A