Decision Making in Marijuana Users

大麻使用者的决策

基本信息

批准号：
7341686
负责人：
LINDA J. PORRINO
金额：
$ 27.65万
依托单位：
WAKE FOREST UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-04-10 至 2009-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7341686
关键词：
Back Behavior Behavioral Brain Chronic Cognitive Complex Daily Data Data Set Decision Making Development Dimensions Discriminant Analysis Drug usage Drug user Elements Emotional Event Exhibits Functional Magnetic Resonance Imaging Functional disorder Future Gambling Goals Illicit Drugs Impulsive Behavior Impulsivity Individual Iowa Knowledge Laboratories Life Magnetic Resonance Imaging Marijuana Marijuana Abuse Measures Motor Movement Nature Neurobiology Numbers Occupations Pattern Performance Pharmaceutical Preparations Plant Roots Population Process Public Health Range Rehabilitation therapy Relative (related person)Reporting Research Personnel Short-Term Memory Source System Task Performances Testing Thinking Today United States base day drug of abuse mathematical model neural circuit programs relating to nervous system response skills

Back Behavior Behavioral Brain Chronic Cognitive Complex Daily Data Data Set Decision Making Development Dimensions Discriminant Analysis Drug usage Drug user Elements Emotional Event Exhibits Functional Magnetic Resonance Imaging Functional disorder Future Gambling Goals Illicit Drugs Impulsive Behavior Impulsivity Individual Iowa Knowledge Laboratories Life Magnetic Resonance Imaging Marijuana Marijuana Abuse Measures Motor Movement Nature Neurobiology Numbers Occupations Pattern Performance Pharmaceutical Preparations Plant Roots Population Process Public Health Range Rehabilitation therapy Relative (related person)Reporting Research Personnel Short-Term Memory Source System Task Performances Testing Thinking Today United States base day drug of abuse mathematical model neural circuit programs relating to nervous system response skills

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项目摘要

Marijuana is the most widely used illicit drug in the United States today, with over 5 million individuals reports use within the last 20 days. Decision making is required for behaviors ranging from simple motor movements to complex reasoning about future consequences. A recent report from our lab has shown that marijuana users have impaired decision making as measured by the Iowa Gambling Task, a laboratory- based decision making task. Marijuana users, as compared to controls, made significantly more risky choices. Furthermore, mathematical modeling of these data has suggested that marijuana users perform poorly because they have deficient cognitive and response style processes. The overall goal of this application, then, is to isolate the specific processes underlying the poor performance of marijuana users by investigating performance on tasks specific to each of these two processes. In the proposed studies recent heavy marijuana users will be compared to non-using controls on performance of an N-back task, a test of working memory and a GO/NOGO task, a test of impulsive response style, as well as the Gambling Task. In addition, functional magnetic resonance imaging (fMRI) will be used to examine brain activity during the performance of these three tasks. Discriminant analyses will be used to distinguish the relationship among performance measures in an effort to identify the root causes of deficient decision-making in this population. We will also relate patterns of brain activity to performance variables and to each other to look for common elements across patterns. This will provide information about the underlying neural processes associated with, chronic marijuana use. Because marijuana is often thought to be less risky than other abused drugs, its potential deleterious effects are often ignored or unrecognized. Chronic marijuana use is therefore a major national public health concern. The present studies seek to identify the nature and sources of deficient decision-making by marijuana users.

大麻是当今美国使用最广泛的非法药物，有超过500万个人的报告在过去20天内使用。从简单电机到的行为需要决策关于未来后果的复杂推理的运动。我们实验室的最新报告表明大麻使用者损害了由爱荷华州赌博任务衡量的决策，这是一个实验室 - 基于决策任务。与对照组相比，大麻使用者的风险更大选择。此外，这些数据的数学建模表明大麻用户执行因为它们缺乏认知和响应样式过程，所以很差。总体目标因此，应用是要隔离大麻用户表现不佳的特定过程调查针对这两个过程中每个过程的任务的绩效。在拟议的研究中大麻使用者将与不利用N-BACK任务的不使用控制进行比较，测试工作记忆和GO/NOGO任务，冲动响应样式的测试以及赌博任务。在此外，功能磁共振成像（fMRI）将用于检查在此期间的大脑活动这三个任务的执行。判别分析将用于区分绩效措施是为了确定该人群中决策不足的根本原因。我们还将将大脑活动的模式与性能变量联系起来，彼此之间寻找常见跨模式的元素。这将提供有关相关神经过程的信息与慢性大麻使用。因为通常认为大麻的风险比其他滥用药物的风险要小，所以它的潜在有害影响通常被忽略或未被认可。因此，长期使用大麻是国家的主要公共卫生忧虑。本研究旨在确定不足决策的性质和来源大麻使用者。