Decision Making in Marijuana Users

大麻使用者的决策

• 批准号: 7095657
• 负责人: LINDA J. PORRINO
• 金额: $ 29.06万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-10 至 2009-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7095657
• 关键词: Cannabis; clinical research; decision making; performance

DESCRIPTION (provided by applicant): Marijuana is the most widely used illicit drug in the United States today, with over 5 million individuals reports use within the last 20 days. Decision making is required for behaviors ranging from simple motor movements to complex reasoning about future consequences. A recent report from our lab has shown that marijuana users have impaired decision making as measured by the Iowa Gambling Task, a laboratory- based decision making task. Marijuana users, as compared to controls, made significantly more risky choices. Furthermore, mathematical modeling of these data has suggested that marijuana users perform poorly because they have deficient cognitive and response style processes. The overall goal of this application, then, is to isolate the specific processes underlying the poor performance of marijuana users by investigating performance on tasks specific to each of these two processes. In the proposed studies recent heavy marijuana users will be compared to non-using controls on performance of an N-back task, a test of working memory and a GO/NOGO task, a test of impulsive response style, as well as the Gambling Task. In addition, functional magnetic resonance imaging (fMRI) will be used to examine brain activity during the performance of these three tasks. Discriminant analyses will be used to distinguish the relationship among performance measures in an effort to identify the root causes of deficient decision-making in this population. We will also relate patterns of brain activity to performance variables and to each other to look for common elements across patterns. This will provide information about the underlying neural processes associated with, chronic marijuana use. Because marijuana is often thought to be less risky than other abused drugs, its potential deleterious effects are often ignored or unrecognized. Chronic marijuana use is therefore a major national public health concern. The present studies seek to identify the nature and sources of deficient decision-making by marijuana users.

描述（由申请人提供）：大麻是当今美国使用最广泛的非法药物，在过去20天内使用了超过500万个人的报告。从简单的运动运动到关于未来后果的复杂推理，需要决策。我们实验室的最新报告表明，大麻使用者损害了由爱荷华州赌博任务（基于实验室的决策任务）衡量的决策。与对照组相比，大麻使用者做出了更大的风险选择。此外，这些数据的数学建模表明，大麻使用者的性能不佳，因为他们的认知和响应样式过程不足。因此，该应用程序的总体目标是通过调查针对这两个过程中每个过程的任务的性能来隔离大麻使用者性能差的特定过程。在拟议的研究中，将将最近的重大麻用户与不使用N-BACK任务的性能，工作记忆测试和GO/NOGO任务的不利用控制，对冲动响应样式的测试以及赌博任务进行比较。另外，功能磁共振成像（fMRI）将用于检查这三个任务的性能。判别分析将用于区分绩效指标之间的关系，以确定该人群中决策不足的根本原因。我们还将将大脑活动的模式与性能变量联系起来，并彼此相互联系，以寻找跨模式的共同元素。这将提供有关慢性大麻使用相关的潜在神经过程的信息。由于通常认为大麻比其他滥用药物的风险要小，因此其潜在的有害作用通常被忽略或未被认可。因此，长期使用大麻是国家公共卫生的主要问题。本研究旨在确定大麻使用者不足决策的性质和来源。