Increasing Patient Adherence in Osteoporosis: Transdermal Parathyroid Hormone

提高骨质疏松症患者的依从性：透皮甲状旁腺激素

• 批准号: 7051871
• 负责人: Sung-Yun Kwon
• 金额: $ 13.85万
• 依托单位: THERAJECT, INC.
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7051871
• 关键词: aging; behavioral /social science research tag; bone regeneration; chemical stability; consumable /disposable biomedical equipment; dosage; drug delivery systems; hormone regulation /control mechanism; human tissue; osteoporosis; parathyroid hormones; peptide hormone; peptides; postmortem; technology /technique development; therapy compliance; transdermal drug delivery

DESCRIPTION (provided by applicant): As the baby boomers reach the age where osteoporosis becomes a major health problem, a once daily patch delivering parathyroid hormone (PTH), the only FDA approved therapy producing the effect of bone growth, could improve the lives of millions and dramatically affect the overall health for this soon to be aging population. TheraJect Inc. has patented a novel technology that enables the systemic delivery of PTH to a patient without the use of a standard needle and syringe. The micro "needle" PTH Patch is covered with small, about 500 micrometer long, "needles". These "needles" penetrate the skin and deliver the peptide to the interstitial fluid, but they neither look like a traditional needle nor cause pain or bleeding. As the elderly population is already faced with many significant health obstacles in their daily life, compliance with medical regimens should be made as effortless as possible. With the net effect of bone growth, the PTH patch therapy has the potential to restore autonomy, agency, control, and dignity to elderly patients.

描述（由申请人提供）：随着婴儿潮一代达到骨质疏松症成为主要健康问题的年龄，每日一次的甲状旁腺激素 (PTH) 贴片是 FDA 批准的唯一能产生骨骼生长效果的疗法，可以改善他们的生活。数以百万计的人，并极大地影响了即将老龄化的人口的整体健康。 TheraJect Inc. 已获得一项新技术的专利，该技术能够在不使用标准针头和注射器的情况下向患者全身输送 PTH。微“针”PTH 贴片上覆盖着约 500 微米长的小“针”。这些“针”刺入皮肤并将肽输送到组织液中，但它们看起来不像传统的针，也不会引起疼痛或出血。由于老年人在日常生活中已经面临许多重大的健康障碍，因此应尽可能轻松地遵守医疗方案。凭借骨骼生长的净效应，PTH 补片疗法有可能恢复老年患者的自主性、代理性、控制力和尊严。