Continuous, Automated, Mandibular Distraction Device

连续、自动、下颌牵引装置

基本信息

批准号：
7062136
负责人：
JOHN C MAGILL
金额：
$ 41.49万
依托单位：
PHYSICAL SCIENCES, INC
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-07-01 至 2008-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7062136
关键词：
bioengineering /biomedical engineering biomedical equipment development bone regeneration clinical biomedical equipment dental implants mandible /maxilla medical implant science miniature biomedical equipment miniature swine osteogenesis

项目摘要

DESCRIPTION (provided by applicant): Physical Sciences Inc. (PSI), in partnership with clinicians in the Massachusetts General Hospital Department of Oral and Maxillofacial Surgery, proposes to continue development of an innovative device for performing distraction osteogenesis (DO) of the mandible. The concept under development uses miniature hydraulics in a fully buried actuator capable of producing linear and curvilinear distraction trajectories. This new distractor will reduce patient responsibility by automating the motion process, permit clinicians to alter the distraction rate of motion as treatment progresses, and reduce distraction time by making the motion virtually continuous. It will also offer the option of fully-buried placement, with no linkages or electrical connections passing through skin. Phase I demonstrated feasibility of the concept with bench top measurements and tests with the prototype implanted in a pig cadaver. All of the proposed Phase I objectives were completed, and the team was able to complete several development steps beyond the proposed Phase I effort. We propose herein to build on the initial success with a Phase II program that will refine the design, produce several prototypes, and perform testing in live animals. Though additional testing will be required, the Phase II work will develop all of the essential components necessary to produce a clinically-useful distractor.

描述（由申请人提供）：Physical Sciences Inc. (PSI) 与马萨诸塞州总医院口腔颌面外科的临床医生合作，提议继续开发一种用于进行下颌骨牵引成骨 (DO) 的创新设备。正在开发的概念在全埋式执行器中使用微型液压系统，能够产生线性和曲线牵引轨迹。这种新型分心器将通过自动化运动过程来减少患者的责任，允许临床医生随着治疗的进展改变运动的分心速率，并通过使运动几乎连续来减少分心时间。它还将提供完全掩埋放置的选项，没有穿过皮肤的连杆或电气连接。第一阶段通过台式测量和植入猪尸体原型的测试证明了该概念的可行性。所有提议的第一阶段目标均已完成，团队能够完成超出提议的第一阶段工作的多个开发步骤。我们在此建议在第二阶段计划的初步成功的基础上，该计划将完善设计，生产多个原型，并在活体动物中进行测试。尽管需要进行额外的测试，但第二阶段的工作将开发生产临床上有用的牵引器所需的所有基本组件。

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Continuous mandibular distraction osteogenesis: novel device and preliminary results in minipigs.

连续下颌牵张成骨：新型装置和小型猪的初步结果。

DOI：
10.1016/j.joms.2012.09.012
发表时间：
2013-04-01
期刊：
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
影响因子：
0
作者：
Batya R. Goldwaser;J. Magill;M. Papadaki;M. Byl;Roger Kromann;Brent Yates;J. Morency;L. Kaban;M. Troulis
通讯作者：
M. Troulis

Automating skeletal expansion: An implant for distraction osteogenesis of the mandible.

自动骨骼扩张：用于下颌骨牵引成骨的植入物。

DOI：
发表时间：
2009-03
期刊：
影响因子：
0
作者：
Magill, John C;Byl, Marten F;Goldwaser, Batya;Papadaki, Maria;Kromann, Roger;Yates, Brent;Morency, Joseph R;Kaban, Leonard B;Troulis, Maria J
通讯作者：
Troulis, Maria J

Automated continuous mandibular distraction osteogenesis: review of the literature.

自动连续下颌牵张成骨：文献综述。