Exercise and the Brain: Fight Against Juvenile Obesity

运动与大脑：对抗青少年肥胖

• 批准号: 7369770
• 负责人: Christa M Patterson
• 金额: $ 1.52万
• 依托单位: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-14 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7369770
• 关键词: Adolescent; Adult; Body Weight; Brain; Child; Development; Diet; Eating; Epidemic; Exercise; Fatty acid glycerol esters; Health; Homeostasis; Human; Hypothalamic structure; Intake; Leptin; Link; Metabolic; Modeling; Neurologic; Neuropeptides; Obesity; POMC gene; Physiological; Prevalence; Pro-Opiomelanocortin; Purpose; Rattus; Regulation; Risk; Running; Signal Transduction; early onset; feeding; fight against; mRNA Expression; obesity treatment; prevent; relating to nervous system

DESCRIPTION (provided by applicant): The prevalence of obesity has grown to epidemic proportions and has been linked to severe health risks. In order for adequate treatments for obesity to be developed it must first be understood how obesity develops, what neural and physiological substrates are involved, and how external factors can influence it. The purpose of these studies is to use the diet-induced rat model of obesity to assess the neurological and physiological effects of exercise during the critical juvenile period of obesity development. Specifically, these studies will assess changes in food intake, body weight, and defense of body weight when juvenile rats are placed on a high fat diet and given free access to a running wheel and these aspects of energy homeostasis will be tracked through to adulthood. This model will mimic the onset of obesity in children who consume a high fat diet and participate in regular activity. In addition, these studies will focus on known neurological deficits in diet-induced rats and how exercise may serve to reverse these. The overall aim of these studies is to understand how exercise influences energy homeostasis and how exercise may serve to treat human obesity.

描述（由申请人提供）：肥胖症的流行率已增长到流行比例，并与严重的健康风险有关。为了使肥胖的适当治疗方法首先必须理解肥胖的发展，涉及哪些神经和生理底物以及外部因素如何影响它。这些研究的目的是使用饮食引起的肥胖大鼠模型来评估肥胖少年发育的关键少年时期的运动神经和生理影响。具体来说，这些研究将评估食物摄入，体重和体重的防御变化，当少年大鼠放在高脂饮食上，并免费进入跑步轮，并且能量体内平衡的这些方面将追踪到成年。该模型将模仿食用高脂饮食并参加常规活动的儿童的肥胖症。此外，这些研究将集中于饮食引起的大鼠中已知的神经缺陷，以及运动如何扭转这些障碍。这些研究的总体目的是了解运动如何影响能量稳态以及运动如何用于治疗人类肥胖。

项目成果

Three weeks of early-onset exercise prolongs obesity resistance in DIO rats after exercise cessation.

三周的早期运动可延长 DIO 大鼠停止运动后的肥胖抵抗力。

• DOI: 10.1152/ajpregu.00661.2007
• 发表时间: 2008
• 期刊: American journal of physiology. Regulatory, integrative and comparative physiology
• 作者: Patterson,ChristaM;Dunn-Meynell,AmbroseA;Levin,BarryE
• 通讯作者: Levin,BarryE