Exercise and the Brain: Fight Against Juvenile Obesity

运动与大脑：对抗青少年肥胖

• 批准号: 7008882
• 负责人: Christa M Patterson
• 金额: $ 2.92万
• 依托单位: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-14 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7008882
• 关键词: appetite regulatory center; autoradiography; bioenergetics; biological signal transduction; body weight; dietary lipid; exercise; homeostasis; hypothalamus; immunocytochemistry; juvenile animal; laboratory rat; leptin; longitudinal animal study; messenger RNA; neuropeptide Y; nutrient intake activity; nutrition related tag; obesity; polymerase chain reaction; predoctoral investigator; proopiomelanocortin; radioimmunoassay; receptor sensitivity; weight control

DESCRIPTION (provided by applicant): The prevalence of obesity has grown to epidemic proportions and has been linked to severe health risks. In order for adequate treatments for obesity to be developed it must first be understood how obesity develops, what neural and physiological substrates are involved, and how external factors can influence it. The purpose of these studies is to use the diet-induced rat model of obesity to assess the neurological and physiological effects of exercise during the critical juvenile period of obesity development. Specifically, these studies will assess changes in food intake, body weight, and defense of body weight when juvenile rats are placed on a high fat diet and given free access to a running wheel and these aspects of energy homeostasis will be tracked through to adulthood. This model will mimic the onset of obesity in children who consume a high fat diet and participate in regular activity. In addition, these studies will focus on known neurological deficits in diet-induced rats and how exercise may serve to reverse these. The overall aim of these studies is to understand how exercise influences energy homeostasis and how exercise may serve to treat human obesity.

描述（由申请人提供）：肥胖症的流行已达到流行病的程度，并与严重的健康风险有关。为了开发出适当的肥胖治疗方法，必须首先了解肥胖是如何发生的、涉及哪些神经和生理基质以及外部因素如何影响它。这些研究的目的是利用饮食诱导的肥胖大鼠模型来评估运动在肥胖发展的关键青少年时期对神经和生理的影响。具体来说，这些研究将评估幼年大鼠接受高脂肪饮食并自由使用跑轮时食物摄入量、体重和体重防御的变化，并且能量稳态的这些方面将被跟踪到成年期。该模型将模拟食用高脂肪饮食并参加定期活动的儿童的肥胖发作。此外，这些研究将重点关注饮食引起的大鼠已知的神经功能缺陷以及运动如何扭转这些缺陷。这些研究的总体目标是了解运动如何影响能量稳态以及运动如何有助于治疗人类肥胖。