CLINICAL TRIAL: RISPERIDONE AND BEHAVIOR THERAPY IN CHILDREN WITH PDD

临床试验：PDD 儿童的利培酮和行为疗法

• 批准号: 7718622
• 负责人: MICHAEL George AMAN
• 金额: $ 0.94万
• 依托单位: OHIO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-12-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7718622
• 关键词: Adaptive Behaviors; Aggressive behavior; Behavior Therapy; Child; Clinical Trials; Compliant Behaviors; Computer Retrieval of Information on Scientific Projects Database; Daily; Funding; Grant; Institution; Life; Measures; Parents; Pharmaceutical Preparations; Randomized Controlled Clinical Trials; Rate; Relapse; Research; Research Personnel; Resources; Risperidone; Self-Injurious Behavior; Source; Training; United States National Institutes of Health; Week; discontinuation trial; follow-up; skills; treatment effect

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. 1) to compare the benefits of risperidone only to risperidone + parent management training (PMT) on a measure of non-compliant behavior in children with PDD accompanied by tantrums, aggression, and/or self injury ("high irritability") in a 24-week randomized trial. 2) to compare the benefits of risperidone only to risperidone + PMT on adaptive behavior (daily living skills) in children with PDD and high irritability in a 24-week randomized trial. 3) to compare the rate of relapse when the medication is gradually withdrawn in a 10-week discontinuation trial in children treated successfully for up to 24 weeks with medication only or medication + PMT. 4) to evaluate enduring effects of these treatments at follow-up 20 months after study entry.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此，可以在其他清晰的条目中表示。列出的机构是 对于中心，这不一定是调查员的机构。 1）将利培酮的益处与利培酮 +父母管理培训（PMT）进行比较，以衡量PDD儿童不合规行为的量度，并伴有发脾气，侵略性和/或自我伤害（“高烦恼”） - 周随机试验。 2）在24周的随机试验中，将利培酮与利培酮 + PMT的好处相比，对PDD和高烦躁的儿童的适应性行为（日常生活技能）进行比较。 3）比较在5周的停用试验中逐渐撤回药物的复发率，该试验在仅使用药物或药物 + PMT的儿童成功治疗长达24周的儿童中。 4）在研究后20个月后，在随访中评估这些治疗的持久影响。