Signal Transduction within the Nucleus Gordon Conference

核戈登会议内的信号转导

• 批准号: 7362456
• 负责人: John D. York
• 金额: --
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7362456
• 关键词: Agonist; Architecture; Cancer Biology; Cell Nucleus; Chromatin Structure; Complex; DNA Repair; DNA Repair Pathway; Dental crowns; Devices; Disease; Ensure; Environment; Enzymes; Fertilization; Functional disorder; Funding; Health; Human; Lipids; Messenger RNA; Modification; Nuclear; Nuclear Envelope; Organism; Pathway interactions; Premature aging syndrome; Process; Progeria; RNA Splicing; Regulation; Research; Research Personnel; Role; Secure; Signal Pathway; Signal Transduction; Work; carbohydrate metabolism; improved; programs; symposium

DESCRIPTION (provided by applicant): This application seeks partial funding for the Gordon Research conference entitled "Signal Transduction within the Nucleus" to be held March 25-30, 2007 at the Crown Plaza Hotel, Venura CA, USA. Our highly successful inaugural meeting was held February, 2005 and we seek to also secure funding commitment for our third meeting to be held in Spring 2009. This conference brings together a wide variety of investigators focused on understanding how signaling pathways participate in the regulation of nuclear processes. Numerous enzymes and macromolecular machines contribute to the complex ensemble of decoding devices necessary to ensure an organism's survival in ever-changing environments. The uniqueness of this conference is the mixing of investigators studying signaling pathways with those studying nuclear function whose work has converged. We have significantly broadened this program with respect to both signaling and nuclear processes, well beyond our inaugural conference which focused on agonist-induced nuclear lipid and carbohydrate metabolism. This programs includes nucleo-cytoplasmic signaling, nuclear lipid signaling, chromatin structure and modifications, DNA damage/repair pathways, roles of nuclear organization and spatial architecture, dynamics of the nuclear envelope, and mRNA splicing and export. Many of these pathways and processes have well-established connections to the pathophysiology of disease processes, underscoring their relationship to improving human health. For example, the relationships of DNA repair pathways to cancer biology, and laminopathies to premature aging (progeria). We anticipate that this will be an outstanding and unique meeting that offers the opportunity of cross-fertilization among outstanding investigators. The requested funds will be invaluable to the support of this conference.

描述（由申请人提供）：本申请为题为“核内信号转导”的戈登研究会议寻求部分资金，将于2007年3月25日至30日在美国加利福尼亚州Venura Crown Plaza Hotel举行。我们非常成功的就职会议于2005年2月举行，我们也寻求确保2009年春季举行的第三次会议的资金承诺。该会议汇集了各种各样的调查人员，专注于了解信号通路如何参与调节核过程。许多酶和大分子机器有助于确保生物体在不断变化的环境中生存所必需的解码设备的复杂合奏。这次会议的独特性是研究信号通路与研究工作融合的核功能的研究人员的混合。在信号传导和核过程方面，我们已经大大扩展了该计划，远远超出了我们的首届会议，该会议的重点是激动剂诱导的核脂质和碳水化合物代谢。该程序包括核总质信号传导，核脂质信号传导，染色质结构和修饰，DNA损伤/修复途径，核组织和空间结构的作用，核包膜的动态以及mRNA剪接和出口。这些途径和过程中的许多与疾病过程的病理生理有着良好的联系，强调了它们与改善人类健康的关系。例如，DNA修复途径与癌症生物学的关系以及椎板病与过早衰老之间的关系（后代）。我们预计这将是一次杰出而独特的会议，为杰出调查员提供跨施用的机会。要求的资金对于本次会议的支持将是无价的。