ASM Conference on Manipulation of Nuclear Processes by DNA Viruses

ASM DNA 病毒操纵核过程会议

• 批准号: 7485476
• 负责人: SANDRA K WELLER
• 金额: $ 1.5万
• 依托单位: AMERICAN SOCIETY FOR MICROBIOLOGY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-02-15 至 2009-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7485476
• 关键词: Accounting; Acute; Animals; Antiviral Agents; Area; Awareness; Bioterrorism; Cell Nucleolus; Cell Nucleus; Cells; Cessation of life; Chronic; Chronic Disease; Collection; Communicable Diseases; DNA; DNA Repair; DNA Viruses; Defense Mechanisms; Developed Countries; Developing Countries; Development; Enteral; Environment; Etiology; Family; Gene Expression; Heart Diseases; Herpesviridae; Human; Infection; Infectious Agent; Malignant Neoplasms; Molecular Chaperones; National Security; Nuclear; Outcome; Papilloma; Pathogenesis; Pathway interactions; Play; Polyomavirus; Population; Process; Public Health; Research; Research Personnel; Respiratory Tract Infections; Role; Scientist; Simplexvirus; System; Tumor Suppressor Genes; Viral; Virus; Virus Diseases; Work; biological adaptation to stress; defense response; mortality; nervous system disorder; pathogen; symposium; virus host interaction

DESCRIPTION (provided by applicant): Infectious diseases are the leading cause of mortality worldwide, accounting for approximately 25% of all deaths - a total of 17 million per year. Although most of these deaths occur in developing countries, developed countries are also vulnerable. Naturally occurring agents as well as bioterrorism infectious disease agents pose significant threats to public health and national security. In addition, there is a growing awareness that infectious agents may play a role in the etiology of chronic diseases such as cancer and heart disease. Viral infection and pathogenesis have a huge impact on both human and animal populations Virus- host interactions have long been recognized as playing important roles in determining the course of viral infection. This meeting will bring together researchers who work on DNA viruses which replicate in the nucleus: Polyoma-, Papilloma-, Adeno- and Herpesviruses to discuss virus host interactions occurring in the nucleus. It is becoming clear that these DNA viruses interact with many of the same host pathways. Except for the very large ASV type meeting format, there are few opportunities to meet to discuss the similarities and differences in how nuclear DNA viruses manipulate the host to promote their agenda. Unfortunately, in the early 80s the herpesvirologists stopped meeting with researchers working on smaller DNA viruses. In this proposal, we intend to bring together nuclear DNA virologists to discuss how these important viruses manipulate the nucleus. Current research in the area is aimed at understanding how DNA viruses manipulate the nucleus in various ways including interactions with DNA repair, proteosomal, chaperone and stress response pathways. Viral interactions with the host transcriptional machinery and the nucleolus as well as innate antiviral defense mechanisms which operate in the nucleus will be considered. Interactions with oncogenes and tumor suppressors will also be discussed. Although Polyoma-, Papilloma-, Adeno- and Herpesviruses interact with some of the same host cell pathways, each virus family has evolved unique strategies to create a nuclear environment conducive to viral gene expression and replication. The DNA viruses include many human pathogens causing maladies varying from mild enteric and respiratory infections to devastating acute infections, chronic progressive neurological diseases, and cancer. The outcome of infection with these agents is often determined by the interplay of the hosts antiviral defense responses, and countermeasures that viruses mount to subvert and escape these systems. We have organized a meeting entitled "Manipulation of Nuclear Processes by DNA Viruses" that will bring together a diverse collection of scientists that study nuclear virus-host interactions. All of the DNA viruses alter specific cellular systems to enhance their propagation and spread, and several exciting developments in this field make a meeting that examines the common and unique mechanisms used by different viruses timely.

描述（由申请人提供）： 传染病是全世界死亡的主要原因，约占所有死亡人数的 25%，每年总计 1700 万人。尽管这些死亡大部分发生在发展中国家，但发达国家也很脆弱。自然发生的病原体以及生物恐怖主义传染病病原体对公共卫生和国家安全构成重大威胁。此外，人们越来越意识到传染源可能在癌症和心脏病等慢性疾病的病因学中发挥作用。病毒感染和发病机制对人类和动物群体都有巨大影响。长期以来，病毒与宿主的相互作用一直被认为在决定病毒感染过程中发挥着重要作用。这次会议将汇集研究在细胞核中复制的 DNA 病毒（多瘤病毒、乳头瘤病毒、腺病毒和疱疹病毒）的研究人员，讨论细胞核中发生的病毒宿主相互作用。越来越清楚的是，这些 DNA 病毒与许多相同的宿主途径相互作用。除了非常大的ASV类型的会议形式之外，很少有机会开会讨论核DNA病毒如何操纵宿主来推动其议程的异同。不幸的是，在 80 年代初，疱疹病毒学家不再与研究较小 DNA 病毒的研究人员会面。在这项提案中，我们打算召集核 DNA 病毒学家来讨论这些重要的病毒如何操纵细胞核。目前该领域的研究旨在了解 DNA 病毒如何以各种方式操纵细胞核，包括与 DNA 修复、蛋白体、伴侣和应激反应途径的相互作用。将考虑病毒与宿主转录机制和核仁的相互作用以及在细胞核中起作用的先天抗病毒防御机制。还将讨论与癌基因和肿瘤抑制因子的相互作用。尽管多瘤病毒、乳头瘤病毒、腺病毒和疱疹病毒与一些相同的宿主细胞途径相互作用，但每个病毒家族都进化出了独特的策略来创建有利于病毒基因表达和复制的核环境。 DNA病毒包括许多引起疾病的人类病原体，从轻微的肠道和呼吸道感染到毁灭性的急性感染、慢性进行性神经系统疾病和癌症。这些病原体感染的结果通常取决于宿主抗病毒防御反应的相互作用，以及病毒为颠覆和逃避这些系统而采取的对策。我们组织了一次题为“DNA病毒操纵核过程”的会议，该会议将汇集研究核病毒与宿主相互作用的不同科学家。所有 DNA 病毒都会改变特定的细胞系统以增强其繁殖和传播，该领域的一些令人兴奋的进展使会议及时审查了不同病毒使用的常见和独特机制。