Superior Cardiac MRI using Wideband SSFP at 3 Tesla

使用 3 特斯拉宽带 SSFP 进行卓越的心脏 MRI

• 批准号: 7016566
• 负责人: Krishna S Nayak
• 金额: $ 19.49万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-15 至 2008-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7016566
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; cardiovascular imaging /visualization; clinical research; human subject; image enhancement; magnetic resonance imaging; phantom model

DESCRIPTION (provided by applicant): Cardiac magnetic resonance imaging (MRI) shows great potential but requires substantial improvements in contrast, spatial resolution, and speed. Two recent advances of particular interest are the development of balanced steady state free precession (SSFP) imaging sequences (equivalently known as True-FISP, FIESTA, or Balanced-FFE), and the development and availability of 3 Telsa clinical scanners. Both provide substantial improvements in SNR and contrast but together, 3T and SSFP are relatively incompatible for rapid high-resolution cardiac imaging. Conventional SSFP is critically limited by banding artifacts that require the use of repetition times of 3 ms or less in the heart at 3T. This limits the achievable spatial resolution, and prevents the use of time-efficient acquisition schemes to reduce scan time. The aim of this proposal is to develop and validate a new imaging technique, which we call Wideband SSFP, that uses alternating repetition times to achieve a steady-state that provides up to double the bandwidth of conventional SSFP, with comparable SNR and contrast. This bandwidth improvement allows the use of longer imaging TRs which will supporting readouts on the order of 4 ms, to enable high spatial resolution (increased readout gradient area) and high temporal resolution (using time-efficient acquisition schemes). The goal of this proposal is to fully characterize and develop Wideband SSFP and apply it to rapid high- resolution cardiac MRI at 3 Tesla. Utilizing SNR improvements from the 3T platform and from SSFP sequences to achieve higher spatial and temporal resolution directly addresses the current limitations of clinical cardiac MRI.

描述（由申请人提供）：心脏磁共振成像（MRI）显示出巨大的潜力，但需要在对比度、空间分辨率和速度方面进行实质性改进。最近特别令人感兴趣的两项进展是平衡稳态自由进动 (SSFP) 成像序列（相当于 True-FISP、FIESTA 或 Balanced-FFE）的开发，以及 3 个 Telsa 临床扫描仪的开发和可用性。两者都在 SNR 和对比度方面提供了显着的改进，但 3T 和 SSFP 对于快速高分辨率心脏成像来说相对不兼容。传统的 SSFP 受到条带伪影的严重限制，条带伪影需要在 3T 心脏中使用 3 ms 或更短的重复时间。这限制了可实现的空间分辨率，并阻止使用省时的采集方案来减少扫描时间。该提案的目的是开发和验证一种新的成像技术，我们将其称为宽带 SSFP，该技术使用交替重复时间来实现稳态，提供高达传统 SSFP 两倍的带宽，并具有可比的 SNR 和对比度。这种带宽改进允许使用更长的成像 TR，这将支持 4 ms 量级的读出，从而实现高空间分辨率（增加读出梯度区域）和高时间分辨率（使用高效的采集方案）。该提案的目标是充分表征和开发宽带 SSFP，并将其应用于 3 特斯拉的快速高分辨率心脏 MRI。利用 3T 平台和 SSFP 序列的 SNR 改进来实现更高的空间和时间分辨率，直接解决当前临床心脏 MRI 的局限性。