Molecular and Cellular Bacterial Pathogenesis

分子和细胞细菌发病机制

基本信息

批准号：
7475669
负责人：
David E Briles
金额：
$ 23.84万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
1976
资助国家：
美国
起止时间：
1976-07-01 至 2010-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7475669
关键词：
Molecular Pathogenesis

项目摘要

DESCRIPTION (provided by applicant): This is a revised renewal application for a training program in Molecular and Cellular Bacterial Pathogenesis (MCBP). Progress in molecular and cellular biology over the last 20 years now permits major gains in our understanding of bacterial pathogenesis. These advances will lead to the development of better medical treatments, drugs, and vaccines for the control of human and animal infections. The study of pathogenesis requires that the researcher have expertise in the cellular and molecular biology of both the host and the pathogen. The researcher also requires training in the types of problems encountered during the study of pathogenic mechanisms and in the types of experimental approaches that can be used to solve these problems. For efficient progress to be made in pathogenesis research, it is also important that the researcher be fully aware of what is known about the natural history and pathology of the infections being studied. Knowledge of infection mechanisms of other pathogens is also important. To facilitate the progress of research on bacterial pathogenesis, we have developed this training program for two pre- and two postdoctoral positions. The preceptors include 14 faculty members with strong programs in basic bacterial pathogenesis and bacterial epidemiology, who have mutually interactive research and training programs in their laboratories. The foundation of the predoctoral program is a multi-departmental graduate training program in Cellular and Molecular Biology. This program recruits students from all over the country and the world for Ph.D. training in the biomedical sciences at The University of Alabama at Birmingham (UAB). During their first year at UAB, these students take a rigorous program of core courses in biochemistry, prokaryotic and eukaryotic genetics, cell biology, and immunology. After lab rotations in the first year, the students select a preceptor in one of the participating basic science departments or medical divisions. Their subsequent training in bacterial pathogenesis is under the auspices of the graduate programs of the Departments of Microbiology or Biochemistry. To be appointed to the MCBP program, students must complete their core courses, pass their preliminary exams, and select an appropriate project in bacterial pathogenesis with a MCMP preceptor. Subsequent training involves research supervision from the MCMP advisory committee, advanced courses in bacterial pathogenesis, a bacterial pathogenesis journal club, and laboratory and departmental seminar series. PhD. and M.D. postdoctoral trainees are also required to take the bacterial pathogenesis course and join the journal club. They may also take some of the CMB core courses if they have deficiencies in basic science that need to be remedied. The MCBP advisory committee will advise the trainees in their research and training programs and in their search for a job or postdoctoral position at the completion of their MCBP training.

描述（由申请人提供）：这是分子和细胞细菌发病机制 (MCBP) 培训计划的修订续展申请。过去 20 年分子和细胞生物学的进展使我们对细菌发病机制的理解取得了重大进展。这些进步将导致开发出更好的医疗方法、药物和疫苗来控制人类和动物感染。发病机制的研究要求研究人员具备宿主和病原体的细胞和分子生物学方面的专业知识。研究人员还需要接受有关致病机制研究过程中遇到的问题类型以及可用于解决这些问题的实验方法类型的培训。为了在发病机制研究中取得有效进展，研究人员充分了解所研究感染的自然史和病理学也很重要。了解其他病原体的感染机制也很重要。为了促进细菌发病机制研究的进展，我们为两个博士前和两个博士后职位制定了这个培训计划。导师包括 14 名在基本细菌发病机制和细菌流行病学方面具有较强研究能力的教员，他们在各自的实验室中开展了相互互动的研究和培训项目。博士前项目的基础是细胞和分子生物学的多部门研究生培训项目。该项目面向全国及世界各地招收博士生。在阿拉巴马大学伯明翰分校 (UAB) 接受生物医学科学培训。在阿拉巴马大学的第一年，这些学生学习了严格的生物化学、原核和真核遗传学、细胞生物学和免疫学核心课程。第一年的实验室轮换后，学生们在参与的基础科学系或医学部门中选择一名导师。他们随后在细菌发病机制方面的培训是在微生物学或生物化学系研究生课程的支持下进行的。要被任命为 MCBP 项目的学生，必须完成核心课程、通过初步考试，并与 MCMP 导师一起选择适当的细菌发病机制项目。随后的培训包括 MCMP 咨询委员会的研究监督、细菌发病机制高级课程、细菌发病机制期刊俱乐部以及实验室和部门研讨会系列。博士。医学博士和博士后培训生还需要参加细菌发病机制课程并加入期刊俱乐部。如果他们在基础科学方面有需要弥补的缺陷，他们也可以选修一些 CMB 核心课程。 MCBP 咨询委员会将为学员的研究和培训计划以及在完成 MCBP 培训后寻找工作或博士后职位提供建议。

项目成果

期刊论文数量（29）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Cloning and expression of the beta-D-phosphogalactoside galactohydrolase gene of Lactobacillus casei in Escherichia coli K-12.

干酪乳杆菌β-D-磷酸半乳糖苷半乳糖水解酶基因在大肠杆菌 K-12 中的克隆和表达。

DOI：
10.1128/jb.152.3.1138-1146.1982
发表时间：
1982
期刊：
Journal of bacteriology
影响因子：
3.2
作者：
Lee,LJ;Hansen,JB;Jagusztyn-Krynicka,EK;Chassy,BM
通讯作者：
Chassy,BM

Role of the ribosome in suppressing transcriptional termination at the pyrBI attenuator of Escherichia coli K-12.

DOI：
10.1073/pnas.85.19.7149
发表时间：
1988-10
期刊：
Proceedings of the National Academy of Sciences of the United States of America
影响因子：
11.1
作者：
Kenneth L. Roland;Chongguang Liu;C. Turnbough
通讯作者：
Kenneth L. Roland;Chongguang Liu;C. Turnbough

Cytomegalovirus infection of breast milk and transmission in infancy.