Natural History, Comorbid Mental Disorders, and Consequences of Inhalant Abuse

自然史、共病精神障碍以及吸入性滥用的后果

基本信息

批准号：
7497094
负责人：
MATTHEW O HOWARD
金额：
$ 17.02万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-15 至 2010-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7497094
关键词：
Accident and Emergency department Accounting Acculturation Adult Age Alcohol or Other Drugs use Alcohols Area Case Study Case-Control Studies Chronic Clinical Clinical Trials Comorbidity Complex Condition Control Groups DSM-IV Data Data Set Development Diagnosis Diagnostic Disease Disease remission Drug Use Disorder Drug abuse Drug usage Drug user Ensure Environment Epidemiologist Exposure to Future Gasoline Gender General Population Glues Health Healthcare Hispanics Hospitalization Household Immigration Individual Inhalant dose form Intervention Investigation Legal Status Life Literature Malignant - descriptor Medical Mental Health Mental disorders National Institute of Drug Abuse Natural History Numbers Outcome Personality Personality Disorders Population Prevalence Prevention Productivity Public Health Publishing Rate Recording of previous events Reporting Research Research Personnel Resources Respondent Risk Risk Factors Role Sampling Structure Substance Use Disorder Surveys Taxonomy Work base comparative cost design drug abuser experience functional disability functional outcomes health care service utilization inhalation drug abuse knowledge base member neglect programs response social treatment trial

项目摘要

DESCRIPTION (provided by investigator): Inhalant use is among the most pernicious and poorly studied forms of drug abuse. Little is known about the natural history, long-term health and social consequences, functional impairments, psychiatric comorbidities, and treatment experiences of inhalant users in the general population. The proposed study will draw upon data recently collected in association with the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC), a 3-wave longitudinal investigation of a nationally representative sample (N= 43,093) of adults living in the U.S. NESARC is one of the largest psychiatric comorbidity studies ever conducted and the first to assess DSM-IV Axis II Personality Disorders, yet no inhalant studies using NESARC data have been published. Wave 1 data are available for use, response rates were high, and the dataset includes 106 variables specific to inhalant use and DSM-IV Inhalant Use Disorders. The proposed research will constitute the most comprehensive set of population-based investigations of inhalant use heretofore undertaken and will greatly increase the knowledge base upon which new inhalant prevention and clinical interventions can be developed by: 1) identifying risk factors for inhalant use and Inhalant Use Disorders and developing an empirically-based taxonomy identifying subtypes of inhalant users, 2) describing the natural history of Inhalant Use Disorders in the general population, including factors predicting onset, escalation, persistence, and stable remission of inhalant use and Inhalant Use Disorders, 3) estimating the prevalence of psychiatric disorders in individuals with lifetime inhalant use/Inhalant Use Disorders and the prevalence of inhalant use/Inhalant Use Disorders among individuals with different psychiatric disorders, and conducting case- control studies evaluating the extent to which inhalant users are' at elevated risk for psychiatric disorders compared to other drug abusers and respondents without drug use disorders, 4) evaluating the independent contribution of inhalant use and Inhalant Use Disorders to the development of serious medical conditions, adverse social consequences, and health and mental health-related functional impairments, and 5) describing the substance-related and general medical health care treatment experiences of inhalant users including types of treatment sought, utilization rates, perceived barriers to treatment, and differences between inhalant users and other drug users with regard to these factors.

描述（调查员提供）：吸入使用是最有害和研究不足的药物滥用形式之一。关于自然史，长期健康和社会后果，功能障碍，精神病合并症以及一般人群中吸入使用者的治疗经验知之甚少。拟议的研究将借鉴最近收集的数据，该数据与全国性的酒精和相关条件（NESARC）相关联（NESARC），这是对居住在美国NESARC的全国代表性样本（n = 43,093）的3波纵向研究（n = 43,093）。 NESARC数据已发布。 Wave 1数据可用于使用，响应率很高，并且数据集包含106个特定于吸入使用和DSM-IV吸入使用障碍的变量。 The proposed research will constitute the most comprehensive set of population-based investigations of inhalant use heretofore undertaken and will greatly increase the knowledge base upon which new inhalant prevention and clinical interventions can be developed by: 1) identifying risk factors for inhalant use and Inhalant Use Disorders and developing an empirically-based taxonomy identifying subtypes of inhalant users, 2) describing the natural history of Inhalant Use Disorders in普通人群，包括预测开始，升级，持久性和稳定缓解吸入使用和吸入使用障碍的因素，3）估计患有终生使用/吸入使用障碍的人的精神疾病的患病率，以及对in Haleant/Inhalant in Healant Inhaalant使用的患者的患病率，并进行了不同的患者，并进行了疾病的患者，并进行了疾病的疾病，并进行了指导。与其他没有药物使用障碍的受访者和受访者相比，吸入用户处于较高的精神疾病风险较高的程度，4）评估对严重的医疗状况的发展和不良病健康状况，健康和心理健康型的不良医疗及其在范围内的医疗及其范围以及5）的医疗治疗以及纳入严重的医疗状况的独立贡献，以及5）的医疗疾病，以及5）的范围以及5）寻求治疗，利用率，感知的治疗障碍以及吸入使用者与其他吸毒者在这些因素方面的差异。