Cognition-Emotion-HPA Interaction: Translation Network

认知-情感-HPA 交互：翻译网络

• 批准号: 7022712
• 负责人: Israel Liberzon
• 金额: $ 40.31万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-20 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7022712
• 关键词: behavior test; clinical research; cognition; decision making; emotions; human subject; hypothalamic pituitary adrenal axis; neural information processing; neuroanatomy; neuroendocrine system; neuropsychology; patient oriented research; posttraumatic stress disorder; prefrontal lobe /cortex; psychopathology; stimulus /response

DESCRIPTION (provided by applicant): Emotional and cognitive processes are complementary ways to process information. Emotions provide rapid "gestalt" assessments, and cognition provides deliberative, sequential, and analytic control. Traditionally, these phenomena were examined in isolation and the somatic/neuroendocrine states that accompany emotions have been seen as mere peripheral markers of brain activity. However, neuroendocrine activity actually affects the brain, modulating cognitive and emotional processing. We propose that cognitive, emotional, and somatic (CES) processes in fact constantly interact in reciprocally interconnected feedback loops and that ineffective CES interaction can lead to dysfunctional behavior and psychopathology. A comprehensive account of CES interplay, and its contribution to the development of psychiatric disorders, has yet to emerge. We propose to create a network of cognitive/affective neuroscientists, behavioral endocrinologists and clinical researchers to develop experimental tools to directly examine CES interactions and their role in psychopathology. Six researchers (3 from Michigan and 3 from Columbia) will work together to (1) establish a translational network of clinical and basic behavioral scientists, (2) develop paradigms to study CES interactions, (3) collect pilot data to map the neurocircuitry of CES interaction, and (4) translate this approach to the study of psychopathology. To pursue these aims we propose specific steps towards network building (to create a multidisciplinary team and context for training translational scientists), paradigm development (to create novel experimental approaches), pilot experiments (to begin mapping the CES neurocircuitry), and translation to clinical relevance (by applying the models to psychiatric disorders, starting with PTSD). Three pilot experiments will utilize emotional (social stress), somatic (elevating cortisol) and cognitive manipulations, evaluating impacts in the domains of stimulus appraisal and decision making using neuroanatomical (fMRI), behavioral, and neuroendocrine outcome measures. These experiments will begin mapping CES neurocircuitry, probing interactions between and within prefrontal cortical regions (like cingulate and dorsomedial gyri, insula) and limbic structures (like amygdala, hippocampus, ventral caudate), and facilitate further paradigm development. The collaborative environment and multidisciplinary team will foster translational behavioral science mental health research, developing new paradigms and collecting preliminary data on CES interaction that shape behavior and contribute to psychopathology. It will provide a foundation for larger translational science projects and a context for training the translational scientists of the future.

描述（由申请人提供）：情感和认知过程是处理信息的互补方式。情绪提供快速的“格式塔”评估，认知提供深思熟虑、顺序和分析的控制。 传统上，这些现象是被孤立地检查的，伴随情绪的躯体/神经内分泌状态被视为仅仅是大脑活动的外周标志。然而，神经内分泌活动实际上会影响大脑，调节认知和情绪处理。我们提出，认知、情感和躯体（CES）过程实际上在相互关联的反馈循环中不断相互作用，无效的 CES 交互可能导致功能失调的行为和精神病理学。关于 CES 相互作用及其对精神疾病发展的贡献的全面描述尚未出现。我们建议创建一个由认知/情感神经科学家、行为内分泌学家和临床研究人员组成的网络，以开发实验工具来直接检查 CES 相互作用及其在精神病理学中的作用。 六名研究人员（3 名来自密歇根州，3 名来自哥伦比亚大学）将共同努力 (1) 建立临床和基础行为科学家的转化网络，(2) 开发研究 CES 相互作用的范式，(3) 收集试点数据以绘制神经回路图CES 互动，以及 (4) 将这种方法转化为精神病理学的研究。为了实现这些目标，我们提出了网络建设（创建多学科团队和培训转化科学家的环境）、范式开发（创建新颖的实验方法）、试点实验（开始绘制 CES 神经回路）和转化为临床的具体步骤。相关性（通过将模型应用于精神疾病，从创伤后应激障碍（PTSD）开始）。三个试点实验将利用情绪（社会压力）、躯体（升高皮质醇）和认知操作，利用神经解剖学（fMRI）、行为和神经内分泌结果测量来评估刺激评估和决策领域的影响。这些实验将开始绘制 CES 神经回路，探测前额皮质区域（如扣带回和背内侧回、岛叶）和边缘结构（如杏仁核、海马体、腹侧尾状核）之间和内部的相互作用，并促进进一步的范式发展。 协作环境和多学科团队将促进转化行为科学心理健康研究，开发新范式并收集 CES 互动的初步数据，这些数据塑造行为并有助于精神病理学。它将为更大的转化科学项目提供基础，并为培训未来的转化科学家提供环境。