Reliable and Robust ECG Gating Signal for Cardiac MR Imaging

用于心脏 MR 成像的可靠且稳定的心电图门控信号

• 批准号: 7455893
• 负责人: Thomas H Frank
• 金额: $ 86.41万
• 依托单位: PERINATRONICS MEDICAL SYSTEMS, INC.
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7455893
• 关键词: Algorithms; Area; Arrhythmia; Blur; Capital; Cardiac; Cardiovascular system; Clinical; Compatible; Computers; Consumption; Data; Data Quality; Databases; Defect; Detection; Devices; Diagnostic; Effectiveness; Electrocardiogram; Electrodes; Electromagnetics; Ensure; Evaluation; Goals; Gold; Heart; Image; Imaging technology; Individual; Infusion procedures; Lead; Least-Squares Analysis; Legal patent; Magnetic Resonance; Magnetic Resonance Imaging; Magnetism; Marketing; Medical; Medical Device; Methods; Monitor; Morphologic artifacts; Motion; Myocardium; Noise; Numbers; Operative Surgical Procedures; Optics; Patients; Performance; Perfusion; Personal Satisfaction; Phase; Physiologic pulse; Preparation; Pulse taking; Radiologic Health; Rate; Research; Research Design; Scanning; Scheme; Signal Transduction; Specific qualifier value; Standards of Weights and Measures; Structure; System; Techniques; Telemetry; Testing; Time; base; carbon fiber; commercialization; computerized data processing; conditioning; data acquisition; electric impedance; experience; human subject; improved; innovation; novel; performance tests; prevent; prototype; respiratory; sensor; size; statistics; transmission process; vector

DESCRIPTION (provided by applicant): Magnetic Resonance Imaging (MRI) has become the gold standard for the quantitative assessment of cardiac structure and function. The key to imaging the moving myocardium is a reliable and robust electrocardiogram signal which, used as a "trigger," can provide images at specified phases throughout the cardiac cycle. Stronger field strength magnets, greater magnetic gradient slew rates, and an ever increasing number of magnetic gradient pulse sequences such as those that provide cardiac perfusion have significantly increased the difficulties of triggering. In addition, individuals with sick hearts may have abnormal ECGs. The focus of this Phase II project is to research, develop and clinically evaluate our innovative real-time, reliable and robust system for ECG triggering during cardiac MR imaging. The project has four specific aims. The first three, aimed at developing an effective MR ECG triggering system, are: 1) to optimize the Phase I prototype MRI ECG data acquisition, fiberoptic transmission system; 2) to optimize, evaluate and test our adaptive noise cancellation methods to remove the RF and magnetic gradient artifacts that overwhelm ECG detection, and 3) to develop a "real-time" embedded computer ECG trigger system and integrate it into a cardiovascular MR imaging system. Our last specific aim is to clinically analyze and evaluate the effectiveness of our MRI ECG trigger system. Our preliminary results illustrate the effectiveness of our methods in reliably detecting the ECG during MR imaging. Our methods include generating a novel optimal ECG vector for detection, and applying effective adaptive noise cancellation methods to extract the ECG R-wave from RF and gradient artifacts. Additional preliminary data demonstrates the capability of our optical telemetry system to transmit the ECG from the magnet and mitigate against the MR artifacts which corrupt the ECG signal. During Phase II, we will evaluate the performance of our triggering system using normal human subjects and a recorded data base of ECG arrhythmias and other defects. Our approach should provide a reliable and robust ECG trigger with minimal delay from the onset of the R-wave. Such a trigger would minimize blurring artifacts from cardiac and respiratory motion and improve MR tagging studies. KEYWORDS: Cardiac Magnetic Resonance Imaging, Magnetic Resonance ECG Triggering (Gating), ECG detection, cardiac imaging (MRI).

描述（由申请人提供）：磁共振成像（MRI）已成为定量评估心脏结构和功能的金标准。移动心肌成像的关键是可靠且稳定的心电图信号，该信号用作“触发器”，可以在整个心动周期的特定阶段提供图像。更强的磁场强度磁体、更大的磁梯度转换速率以及不断增加的磁梯度脉冲序列（例如提供心脏灌注的脉冲序列）数量显着增加了触发的难度。此外，患有心脏疾病的人可能会出现心电图异常。该二期项目的重点是研究、开发和临床评估我们创新的实时、可靠和强大的系统，用于心脏 MR 成像期间的心电图触发。该项目有四个具体目标。前三项旨在开发有效的 MR 心电图触发系统，分别是：1）优化 I 期原型 MRI 心电图数据采集、光纤传输系统； 2) 优化、评估和测试我们的自适应噪声消除方法，以消除干扰心电图检测的射频和磁梯度伪影，以及 3) 开发“实时”嵌入式计算机心电图触发系统并将其集成到心血管 MR 成像中系统。我们的最后一个具体目标是临床分析和评估我们的 MRI 心电图触发系统的有效性。我们的初步结果说明了我们的方法在 MR 成像过程中可靠检测心电图的有效性。我们的方法包括生成用于检测的新颖的最佳心电图矢量，并应用有效的自适应噪声消除方法从射频和梯度伪影中提取心电图 R 波。其他初步数据证明了我们的光学遥测系统能够传输来自磁铁的心电图并减轻破坏心电图信号的 MR 伪影。在第二阶段，我们将使用正常人类受试者和心电图心律失常和其他缺陷的记录数据库来评估我们的触发系统的性能。我们的方法应该提供可靠且强大的心电图触发，并且从 R 波开始的延迟最小。这样的触发器将最大限度地减少心脏和呼吸运动产生的模糊伪影，并改善 MR 标记研究。关键词：心脏磁共振成像、磁共振心电图触发（门控）、心电图检测、心脏成像 (MRI)。