Low-cost High-resolution fundus camera

低成本高分辨率眼底相机

• 批准号: 7537323
• 负责人: Peter none Soliz
• 金额: $ 3.81万
• 依托单位: VISIONQUEST BIOMEDICAL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2010-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7537323
• 关键词: Address; Adopted; Age related macular degeneration; Astigmatism; Beds; Blood capillaries; Caring; Clinical; Coupled; Development; Devices; Diabetic Retinopathy; Diagnosis; Diagnostic; Disease; Doctor of Philosophy; Early Diagnosis; Engineering; Ensure; Entropy; Excision; Eye; Eye diseases; Fundus; Glaucoma; Goals; Grant; Healthcare Systems; Human; Image; Imagery; Imaging technology; Individual; Iowa; Laboratories; Lasers; Masks; Measurement; Methods; Metric; Modification; Monitor; Mydriatics; Nerve Fibers; Numbers; Operative Surgical Procedures; Ophthalmologist; Ophthalmoscopes; Optic Disk; Optics; Performance; Phase; Price; Prospective Studies; Public Health; Purpose; Radial; Range; Research; Research Personnel; Resolution; Retina; Retinal; Retinal Diseases; Scanning; Scientist; Screening procedure; Source; Standards of Weights and Measures; Structure; System; Techniques; Technology; Testing; Time; Today; Training; Universities; adaptive optics; base; capillary; clinical application; commercialization; cost; design; experience; human subject; improved; insight; instrument; lens; optical sensor; performance tests; prototype; research study; sensor; tool

DESCRIPTION (provided by applicant): The principal objective is to demonstrate clinically a commercially viable, low-cost, high-resolution fundus camera that: is easy to use, i.e., consistent with the operation of current fundus cameras; has a field of view (FOV) that is typical of current fundus cameras (15 to 30 degrees); has a factor of five or more improvement in resolution as compared to existing clinical instruments; and, will be priced below that of today's clinical devices. In Phase I, a low-cost means for removing low-order aberrations, focus and astigmatism, was demonstrated. It was shown that removal of low-order aberrations would result in significantly better resolution images. In Phase II, the specific aims are to integrate the low-cost low-order aberrations compensator into a scanning laser ophthalmoscope (SLO). This new SLO would produce retinal and optic disc images that have five times better resolution when compared to today's commercial cameras. Researchers have sought to gain greater insight into the mechanisms of the retina and the optic disc at high spatial resolutions that would enable the visualization of structures (4 to 8 micrometers) such as capillaries and nerve fiber bundles. Major sources of retinal image quality degradation are aberrations within the human eye. The presence of these ocular aberrations, many of them random and non deterministic, limits the achievable resolution and the contrast of small image details due to diffraction effects. To overcome these fundamental limitations, researchers have been applying adaptive optics techniques to correct for the aberrations. Today, deformable mirror based adaptive optics devices have been developed to overcome the limitations of standard fundus cameras, but at prices in excess of $500,000. The device proposed by VisionQuest addresses the same goals as the above research grade adaptive optics instruments but does so in a manner which will ultimately be better suited for clinical use because of its similarity to current retinal photographic techniques and its lower cost technology. Our proposed device avoids the high costs, complexity, and limited FOV by adopting unique and notably less expensive wavefront measurement and aberration correction techniques. VisionQuest's goal is to demonstrate an advanced imaging technology that introduces an effective and low cost ($10,000 or less) diagnostic tool to the healthcare system. PUBLIC HEALTH RELEVANCE: Retinal imaging for the purposes of diagnosis of retinal diseases or for monitoring the treatment and/or progression of retinal diseases is standard of care. Greatly improved images of the retina, especially at costs that are lower than current fundus cameras, would have a significant impact on our ability to implement broad-scale screening throughout the U.S. for retinal disease. A low-cost retinal camera would enable the early detection and care of individuals with any of the three major eye diseases, i.e., age-related macular degeneration, diabetic retinopathy, or glaucoma.

描述（由申请人提供）：主要目的是证明临床上可行的，低成本，高分辨率的底面摄像头：易于使用，即与当前的底面相机的运行一致；具有当前眼底摄像头（15至30度）的典型观点（FOV）；与现有的临床工具相比，分辨率的分辨率有五倍或更多。并且，将低于当今临床设备的价格。在第一阶段，证明了用于消除低阶畸变，焦点和散光的低成本手段。结果表明，去除低阶畸变将导致明显更好的分辨率图像。在II阶段，具体目的是将低成本的低阶畸变补偿器整合到扫描激光眼镜镜（SLO）中。与当今的商用摄像头相比，这种新的SLO将产生视网膜和视盘图像的分辨率五倍。研究人员试图在高空间分辨率下更深入地了解视网膜和视盘的机制，这将使能够可视化结构（4至8微米），例如毛细血管和神经纤维束。视网膜图像质量下降的主要来源是人眼内的畸变。这些眼畸变的存在，其中许多是随机和非确定性的，限制了由于衍射效应而导致的可实现的分辨率和小图像细节的对比。为了克服这些基本局限性，研究人员一直在应用自适应光学技术来纠正畸变。如今，已经开发了基于镜像的自适应光学设备，以克服标准眼镜摄像机的局限性，但价格超过50万美元。 VisionQuest提出的设备与上述研究级自适应光学仪器的目标相同，但最终将其做到这一点，因为它与当前的视网膜照相技术及其较低的成本技术相似，因此最终将更适合临床使用。我们提出的设备通过采用独特且尤其是便宜的波前测量和畸变校正技术来避免高成本，复杂性和有限的FOV。 VisionQuest的目标是展示一种先进的成像技术，该技术向医疗保健系统带来了有效且低成本（10,000美元或更少）的诊断工具。公共卫生相关性：视网膜成像是为了诊断视网膜疾病的目的或监测视网膜疾病的治疗和/或进展是护理的标准。大大改善了视网膜的图像，尤其是低于目前的底面摄像头的成本，将对我们在整个美国进行大规模筛查的能力产生重大影响。低成本的视网膜摄像头将使患有三种主要眼部疾病的任何人，即与年龄相关的黄斑变性，糖尿病性视网膜病或青光眼进行早期检测和护理。