NIMH Center for Collaborative Genetic Studies

NIMH 合作遗传学研究中心

• 批准号: 6876954
• 负责人: JAY Arnold TISCHFIELD
• 金额: $ 132.88万
• 依托单位: RUTGERS, THE STATE UNIV OF N.J.
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6876954
• 关键词: Internet; behavioral /social science research tag; behavioral genetics; biomedical facility; cell line; cooperative study; data management; family genetics; functional /structural genomics; genetic mapping; genotype; health science research analysis /evaluation; health science research support; informatics; lymphoblast; mental disorders; meta analysis; tissue /cell preparation; tissue resource /registry

DESCRIPTION (provided by applicant): This proposal is driven by the need to find genes that contribute to the etiology of mental disorders; a goal more readily attained if clinical data and biological materials (DNA and cell lines) are openly shared among investigators. During the past four years, the NIMH Center for Genetic Studies (NCGS), established over 13,000 lymphoblast cell lines (LCLs) from blood samples and processed clinical and genotype data submitted by PIs of the NIMH Human Genetics Initiative. The NCGS distributed over 20,000 DNA aliquots and made more than 82 distributions of family, clinical and genotype data to a larger group of investigators. The establishment of these resources has played a critical role in enhancing and invigorating research on the genetics of mental disorders. Drs. Tischfield and Rice propose to continue their NCGS efforts with this application to become the Cooperative Agreement Award-funded (U24) "Center for Collaborative Genetic Studies on Mental Disorders" (the "Center"), submitted in response to RFA MH-03-003. They will continue to produce LCLs as a renewable source of DNA and will maintain an improved and easily accessible, web-based bioinformatics repository of clinical and genotype data that will drive future research. They also propose analyses of shared, public data sets that will add to their predictive value for gene discovery. The Center will provide consultation on project design (e.g., power studies), detailed genomics of candidate regions, blood (or other biologicals) collection, data analysis, and best organization and use of shared resources. The overriding aim of the Center will be to serve the scientific needs of the NIMH PIs, while respecting subject confidentiality, informed consent issues, and PI prerogatives. By encouraging and facilitating the collection and sharing of biologicals as well as clinical and genotype data from subjects or families with mental disorders such as schizophrenia, bipolar disorder, or autism, and its own analyses of these data, the Center will greatly accelerate progress toward understanding the inherited components in the etiology of these diseases.

描述（由申请人提供）：该提案是出于寻找有助于精神障碍病因学的基因的需要而提出的；如果临床数据和生物材料（DNA 和细胞系）在研究人员之间公开共享，则更容易实现这一目标。在过去四年中，NIMH 遗传学研究中心 (NCGS) 从血液样本中建立了超过 13,000 个淋巴母细胞系 (LCL)，并处理了 NIMH 人类遗传学计划的 PI 提交的临床和基因型数据。 NCGS 向更多的研究人员分发了超过 20,000 份 DNA 等分试样，并向更多的研究人员分发了超过 82 份家庭、临床和基因型数据。这些资源的建立在加强和振兴精神障碍遗传学研究方面发挥了关键作用。博士。 Tischfield 和 Rice 建议继续开展 NCGS 工作，通过此申请成为合作协议奖资助 (U24)“精神障碍合作遗传研究中心”（“中心”），该申请是针对 RFA MH-03-003 提交的。他们将继续生产 LCL 作为 DNA 的可再生来源，并将维护一个改进的、易于访问的、基于网络的临床和基因型数据生物信息学存储库，这将推动未来的研究。他们还提出对共享的公共数据集进行分析，这将增加其对基因发现的预测价值。该中心将提供有关项目设计（例如功率研究）、候选区域的详细基因组学、血液（或其他生物制品）收集、数据分析以及共享资源的最佳组织和使用的咨询。该中心的首要目标是满足 NIMH PI 的科学需求，同时尊重受试者机密性、知情同意问题和 PI 特权。通过鼓励和促进收集和共享来自患有精神分裂症、双相情感障碍或自闭症等精神障碍的受试者或家庭的生物制品以及临床和基因型数据，以及自己对这些数据的分析，该中心将大大加快理解的进展这些疾病病因学中的遗传成分。