A Turnkey, Wireless, EEG/EMG/Biosensor Measurement

交钥匙无线脑电图/肌电图/生物传感器测量

• 批准号: 7054542
• 负责人: DAVID A JOHNSON
• 金额: $ 22.54万
• 依托单位: PINNACLE TECHNOLOGY, INC
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-02-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7054542
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; biosensor device; electroencephalography; electromyography; glucose metabolism; laboratory mouse; laboratory rat; portable biomedical equipment; sleep

DESCRIPTION (provided by applicant): The long term objective of this project is to develop, validate and commercialize wireless, head mounted, turnkey, EEG/EMG systems with an integrated biosensor for rats and mice. A further objective is to develop a 76 uM glucose biosensor for direct measurement of brain glucose levels in rats and mice. The specific aims of this Phase I project are to develop and test a 76 uM glucose biosensor, a tethered EEG/EMG/Biosensor solution for mice and a wireless solution for rats. To reach these objectives, Pinnacle Technology, Northwestern University and the University of Kansas are building on past successes in the design of glutamate biosensors, wireless potentiostats for rats, and tethered EEG/EMG systems for mice. These products were developed in separate collaborations and are currently being commercialized. Products to be introduced include: a tethered system for mice, a wireless system for rats, and ultimately a fully wireless system for mice. Commercial applications include sleep research, behavioral research and drug screening. Technological innovations include biosensor design, turnkey head mount design, advanced electronics design, and advanced low power radio frequency design. The ability to measure glucose from specific brain areas in vivo while simultaneously recording sleep in rodents will give researchers the ability to better examine the functioning of specific sites within the brain during the sleep process as well as leverage the advantages conferred by using rat and mouse models for research. At the moment, it is not possible to concurrently study sleep and glucose regulation in a mouse model and there is only one published account where it has been attempted in the rat. The ability to instantly record glucose levels in a sleeping mouse or rat, and correlate that activity with EEG/EMG, will be valuable to researchers studying sleep and metabolism. The investigation of glucose in a mouse model will open up new avenues of research with genetic mutations available in species such as the NIRKO mouse (brain/neuron-specific insulin receptor knockout) which may have altered glucose responses during sleep and provide clues as to how sleep and metabolism are linked.

描述（由申请人提供）：该项目的长期目标是开发、验证和商业化无线、头戴式、交钥匙、带有集成生物传感器的大鼠和小鼠脑电图/肌电图系统。进一步的目标是开发一种 76 uM 葡萄糖生物传感器，用于直接测量大鼠和小鼠的脑葡萄糖水平。该第一阶段项目的具体目标是开发和测试 76 uM 葡萄糖生物传感器、用于小鼠的系留脑电图/肌电图/生物传感器解决方案和用于大鼠的无线解决方案。为了实现这些目标，Pinnacle Technology、西北大学和堪萨斯大学在过去设计谷氨酸生物传感器、大鼠无线恒电位仪和小鼠脑电图/肌电图系留系统方面取得的成功基础上再接再厉。这些产品是单独合作开发的，目前正在商业化。即将推出的产品包括：小鼠系留系统、小鼠无线系统以及最终的全无线小鼠系统。商业应用包括睡眠研究、行为研究和药物筛选。技术创新包括生物传感器设计、交钥匙头戴式设计、先进电子设计和先进低功耗射频设计。测量体内特定大脑区域的葡萄糖，同时记录啮齿类动物的睡眠的能力将使研究人员能够更好地检查睡眠过程中大脑内特定部位的功能，并利用大鼠和小鼠模型所带来的优势用于研究。目前，不可能在小鼠模型中同时研究睡眠和血糖调节，并且只有一篇已发表的文章在大鼠中进行了尝试。即时记录睡眠小鼠或大鼠的血糖水平，并将该活动与脑电图/肌电图相关联的能力，对于研究睡眠和新陈代谢的研究人员来说非常有价值。对小鼠模型中葡萄糖的研究将开辟新的研究途径，例如 NIRKO 小鼠（大脑/神经元特异性胰岛素受体敲除）等物种中存在的基因突变可能会改变睡眠期间的葡萄糖反应，并提供有关如何改变葡萄糖反应的线索。睡眠和新陈代谢是相关的。

项目成果

Lactate as a biomarker for sleep.

乳酸作为睡眠的生物标志物。

• 发表时间: 2012-09-01
• 影响因子: 5.6
• 作者: Naylor, Erik;Aillon, Daniel V;Barrett, Brian S;Wilson, George S;Johnson, David A;Johnson, Donna A;Harmon, Hans P;Gabbert, Seth;Petillo, Peter A
• 通讯作者: Petillo, Peter A