Translation regulation elements in both the 5` and 3` untranslated region; how do they coexist?

5`和3`非翻译区的翻译调控元件；

基本信息

批准号：
BB/F019017/1
负责人：
Martin Bushell
金额：
$ 42.37万
依托单位：
University of Nottingham
依托单位国家：
英国
项目类别：
Research Grant
财政年份：
2008
资助国家：
英国
起止时间：
2008 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=BB%2FF019017%2F1
关键词：
Translation regulation elements both untranslated

项目摘要

Recently, a completely new way of controlling gene expression has been identified. This has come to light after the discovery of a whole new class of genes which, unlike most genes, do not produce proteins. Instead they make very small RNA molecules, called microRNAs. There are at least 800 microRNAs within the human genome which have different effects. They work by binding to the messenger RNA of other genes and inhibiting the production of the proteins made from these genes a process known as translation. Each of these 800 small molecules is believed to interact with 100 other genes, thus adding to the complex regulation of the human genome. Already it has become clear that malfunction of miRNA regulation is associated with a growing list of human diseases, including cancer, diabetes, and viral infections. Other methods of regulating expression of genes at the level of translation also exist, and little is known about how these methods interact with miRNA regulation. This study will analyse the interaction between miRNAs and other control elements in regulating specific genes. It will also look for changes in this regulation that occur when cells are stressed, as many changes in translation occur under these conditions. This study will lead to a greater understanding of how gene expression is controlled and the complexity of the human genome.

最近，已经确定了一种全新的控制基因表达的方法。在发现了一个全新的基因之后，与大多数基因不同，这已经揭示了。相反，它们制作的RNA分子很小，称为microRNA。人类基因组中至少有800个microRNA具有不同的作用。它们通过与其他基因的信使RNA结合并抑制由这些基因制成的蛋白质的产生，一种称为翻译的过程。据信这800个小分子中的每一个都与其他100个基因相互作用，从而增加了人类基因组的复杂调节。已经很明显，miRNA调节的故障与越来越多的人类疾病列表有关，包括癌症，糖尿病和病毒感染。还存在调节基因表达在翻译水平上的其他方法，并且对于这些方法如何与miRNA调节相互作用几乎不知道。这项研究将分析miRNA与其他控制元件之间的相互作用，以调节特定基因。它还将寻找当细胞受到压力时发生的调节中发生的变化，因为在这些条件下翻译的许多变化发生。这项研究将使人们对基因表达的控制方式和人类基因组的复杂性有更深入的了解。