The Effect of Cannabis Use on Human Cerebellar Function

大麻使用对人类小脑功能的影响

基本信息

批准号：
7500650
负责人：
Sharlene D Newman
金额：
$ 20.73万
依托单位：
TRUSTEES OF INDIANA UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-30 至 2010-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7500650
关键词：
Acute Adolescence Adolescent Adult Agonist Air American Anterior Architecture Area Attention Auditory Behavioral Biochemical Biological Assay Blinking Brain CNR1 gene Cannabinoids Cannabis Cannabis sativa plant Carboxylic Acids Cell Communication Cerebellar cortex structure Cerebellum Chronic Clinical Cognition Computer information processing Concept Formation Condition Conditioned Stimulus Cytoplasmic Granules DSM-IV Data Disease Disruption Down-Regulation Drug usage Drug user Electrodes Electroencephalography Endocannabinoids Exhibits Eye Female Fiber Fingers Fright Future Gait Glutamates Human Illicit Drugs Imaging Techniques Individual Individual Differences Interview Intoxication Knowledge Learning Left Length Lobule Magnetic Resonance Imaging Marijuana Mass Chromatography Measures Mediating Methodology Methods Motor Movement Nature Neurons Neuropsychological Tests Neurosciences Numbers Operative Surgical Procedures Outcome Paranoia Patient Self-Report Pattern Perceptual distortions Performance Personal Satisfaction Pharmaceutical Preparations Play Posture Preclinical Drug Evaluation Presynaptic Terminals Procedures Process Property Psychophysiology Public Health Purkinje Cells Questionnaires Rate Reaction Time Reading Research Role Running Short-Term Memory Spectrometry Stimulus Structure Substance Abuse Detection Synapses System Techniques Testing Tetrahydrocannabinol Thinking Time Time Perception Translational Research United States Urine addiction base behavior measurement cannabinoid receptor classical conditioning cognitive function conditioning critical developmental period granule cell inclusion criteria indexing interest male neurodevelopment neuroimaging novel presynaptic psychologic receptor relating to nervous system response theories translational approach urinary young adult

项目摘要

DESCRIPTION (provided by applicant): Marijuana, or Cannabis sativa, is the most commonly used illicit drug in the United States. Increased levels of use occur during adolescence and young adulthood, which is of concern from a public health perspective, since these are also critical periods of neural development. This fear is further underscored by the fact that cannabis may act as a gateway drug, since its use may predispose individuals to abuse other illicit drugs. While it is well known that the active ingredient in cannabis, -9-tetrahydrocannabinol (THC) causes abnormalities in cognitive functions such as short-term memory and attention, there are a paucity of data examining the effect of cannabis use on the functional state of the cerebellum, a neural timing structure that is replete with cannabinoid receptors. Therefore, the overall aim of the current proposal is to examine whether current cannabis users demonstrate abnormalities in cerebellar-mediated classical eye blink conditioning (EBC) and paced finger tapping. In addition, assessments of the structural correlates of these deficits will be determined using magnetic resonance imaging (MRI). It is hypothesized that during the EBC paradigm cannabis users will demonstrate poorer learning performance (less and more poorly timed conditioned responses) as compared to controls. During the paced finger tapping tasks, it is predicted that cannabis users will exhibit increased tapping variability and increased tapping rates. It is also predicted that chronic cannabis users will exhibit decreased cerebellar volumes due to long-term endocannabinoid compensatory mechanisms, and that these volumetric changes will correlate with EBC and paced finger tapping performance. Finally, it is hypothesized that deficits in EBC, paced finger tapping, and cerebellar volume will correlate with the amount and length of cannabis use, including urinary levels of THC metabolites. Taken together, data from these studies will further our understanding of the cannabinoid system, which will help elucidate the mechanism of action of one of the most commonly used drugs of abuse.Project Narrative

描述（由申请人提供）：大麻或大麻Sativa是美国最常用的非法药物。从公共卫生的角度来看，青春期和成年期间的使用水平提高，因为这也是神经发育的关键时期。大麻可以用作门户药物的事实进一步强调了这种恐惧，因为它的使用可能使人易于滥用其他非法药物。众所周知，众所周知，大麻中的活性成分，-9-四氢大麻酚（THC）在认知功能（例如短期记忆和注意力）中引起异常，但研究大麻使用对大麻的功能对大麻的功能状态的数据很少，这是一种与大麻的功能状态，是一种与大麻素受体有关的，这是cannabiroid cannabiridors abanbabiriidorsioidorioid的含量。因此，当前建议的总体目的是检查当前的大麻使用者是否表现出小脑介导的经典眼眨眼调节（EBC）和节奏的手指攻击的异常。另外，将使用磁共振成像（MRI）确定对这些缺陷的结构相关性的评估。可以假设，与对照组相比，在EBC范式范式中，使用者将表现出较差的学习绩效（较少且定时响应较差）。在节奏的手指敲击任务中，可以预测大麻使用者将表现出更高的攻击变异性和提高的敲击率。还可以预测，由于长期内源性大麻素的补偿机制，慢性大麻使用者将表现出小脑体积的减少，并且这些体积变化将与EBC和节奏的手指敲击性能相关。最后，假设EBC的缺陷，节奏的手指敲击和小脑体积将与大麻使用的数量和长度相关，包括THC代谢物的尿液水平。综上所述，这些研究的数据将进一步了解大麻素系统，这将有助于阐明最常用的滥用药物之一的作用机理。

项目成果

期刊论文数量（6）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Examining the effects of former cannabis use on cerebellum-dependent eyeblink conditioning in humans.

检查以前使用大麻对人类小脑依赖性眨眼调节的影响。

DOI：
10.1007/s00213-011-2556-1
发表时间：
2012
期刊：
Psychopharmacology
影响因子：
3.4
作者：
Steinmetz,AdamB;Edwards,ChadR;Vollmer,JenniferM;Erickson,MollyA;O'Donnell,BrianF;Hetrick,WilliamP;Skosnik,PatrickD
通讯作者：
Skosnik,PatrickD

Striatal D(2)/D(3) receptor availability is inversely correlated with cannabis consumption in chronic marijuana users.

DOI：
10.1016/j.drugalcdep.2012.07.016
发表时间：
2013-02-01
期刊：
DRUG AND ALCOHOL DEPENDENCE
影响因子：
4.2
作者：
Albrecht, Daniel S.;Skosnik, Patrick D.;Vollmer, Jennifer M.;Brumbaugh, Margaret S.;Perry, Kevin M.;Mock, Bruce H.;Zheng, Qi-Huang;Federici, Lauren A.;Patton, Elizabeth A.;Herring, Christine M.;Yoder, Karmen K.
通讯作者：
Yoder, Karmen K.

Cerebellar-dependent learning as a neurobehavioral index of the cannabinoid system.

小脑依赖性学习作为大麻素系统的神经行为指标。