Feasibility of Immersive Virtual Reality Cue Reactivity for Nicotine Craving

沉浸式虚拟现实提示反应对尼古丁渴望的可行性

• 批准号: 7530738
• 负责人: PATRICK SHANNON BORDNICK
• 金额: $ 22.31万
• 依托单位: UNIVERSITY OF HOUSTON
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7530738
• 关键词: Address; Adult; Affect; Alcohol dependence; Alcohols; Arousal; Attention; Auditory; Behavioral; Cannabis; Clinical Research; Complex; Condition; Cues; Data; Dependence; Development; Dimensions; Drug Addiction; Elements; Environment; Environmental Impact; Experimental Designs; Exposure to; Goals; Hand; Immersion Investigative Technique; Intervention; Laboratories; Measures; Methods; Modeling; Moods; Nicotine; Outcome; Participant; Pharmaceutical Preparations; Physiological; Public Health; Randomized; Reaction; Relapse; Research; Research Personnel; Sampling; Smoke; Smoker; Smoking; Stimulus; System; Testing; Visual; analog; conditioning; craving; dependence relapse; drug craving; grasp; haptics; innovation; innovative technologies; nicotine craving; research study; response; social; theories; virtual reality

DESCRIPTION (provided by applicant): We proposed to explore the impact of environmental context and cue type in nicotine craving and dependence using an immersive virtual reality cue reactivity system (IVRCR). Traditional cue reactivity approaches have been criticized for lacking realism and not providing exposure in realistic environmental contexts. The proposed IVRCR system provides exposure to complex social cues and realistic interpersonal situations within congruent environmental contexts (e.g. party setting vs. lab room). The impact of environmental context on craving and immersion will be tested in a controlled cue reactivity experiment of 105 adult nicotine dependent smokers. Assignment will be randomized to three context groups who will be exposed to both neutral and smoking cues in either a IVRCR or traditional cue reactivity paradigm. Physiological arousal, subjective craving, immersion, attention to cues, and mood state will be compared between groups and three hypotheses concerning the main effects of smoking context and cue type will be tested. Results will contribute to the conditioning theory of craving and the effect of context in drug dependence and relapse. The study results will provide additional information relevant to generalizability of cues and other significant issues in cue reactivity theory. We proposed to explore the impact of environmental context and cue type in nicotine craving and dependence using an immersive virtual reality cue reactivity system (IVRCR). The proposed IVRCR system provides exposure to complex social cues and realistic interpersonal situations within congruent environmental contexts (e.g. party setting vs. lab room). PUBLIC HEALTH RELEVANCE: We believe that the additions to VR cue methods will sufficiently emulate traditional cue reactivity (non-VR methods), and expand these methods to study the impact of environmental context on craving and dependence, not currently offered in traditional cue approaches.

描述（由申请人提供）：我们建议使用沉浸式虚拟现实提示反应系统（IVRCR）探索环境环境和提示类型在尼古丁渴望和依赖性中的影响。传统的提示反应方法因缺乏现实主义而不提供现实环境环境中的暴露而受到批评。拟议的IVRCR系统可在一致的环境环境（例如政党设置与实验室房间）中接触复杂的社会提示和现实的人际关系情况。环境环境对渴望和沉浸感的影响将在105名成年尼古丁吸烟者的受控反应性实验中进行测试。分配将被随机分为三个上下文组，他们将在IVRCR或传统提示反应性范式中暴露于中性和吸烟线索。将测试生理唤醒，主观渴望，沉浸式，对线索的关注和情绪状态，以及三个关于吸烟环境和提示类型的主要影响的假设之间的情绪状态。结果将有助于渴望的条件理论以及上下文在药物依赖性和复发中的影响。该研究结果将提供与提示和提示反应理论中其他重要问题的概括性有关的其他信息。我们建议使用沉浸式虚拟现实提示反应系统（IVRCR）探讨环境环境和提示类型在尼古丁渴望和依赖性中的影响。拟议的IVRCR系统可在一致的环境环境（例如政党设置与实验室房间）中接触复杂的社会提示和现实的人际关系情况。公共卫生相关性：我们认为，VR提示方法的增加将充分模拟传统的提示反应性（非VR方法），并扩展这些方法以研究环境环境对渴望和依赖性的影响，目前尚未在传统的提示方法中提供。