Intimate Partner Violence and Inflammatory Processes

亲密伴侣暴力和炎症过程

• 批准号: 7094376
• 负责人: TAMARA L. NEWTON
• 金额: $ 18.08万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-15 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7094376
• 关键词: C reactive protein; aggression; behavioral /social science research tag; biomarker; chronic disease /disorder; clinical research; disease /disorder proneness /risk; divorce /separation; domestic violence; dyadic interaction; female; human subject; inflammation; interleukin 6; interview; postmenopause; posttraumatic stress disorder; psychological aspect of aging; psychological stressor; psychoneuroimmunology; psychosocial separation; sex partner; spouse abuse; women' s health

DESCRIPTION (provided by applicant): This study will test associations between prior exposure to adult intimate partner violence (IPV) and inflammatory markers and processes that have been implicated in a variety of conditions associated with aging (e.g., cardiovascular diseases, cognitive decline). It is proposed that IPV can have long-standing consequences for inflammatory processes, particularly via the pathway of intrusive re-experiencing (e.g., recurrent, unwanted memories of prior stressful events, and physiological reactions to events reminders). Aim 1 is to establish the relationship between prior exposure to adult IPV and inflammatory markers and processes. Aim 2 is to examine how severity of IPV and severity of intrusive re-experiencing interactively contribute to inflammatory markers and processes. These aims will be examined in a cross-sectional study of two groups of healthy women who are newly postmenopausal; (1) women who are divorced/separated from violent marriages or heterosexual cohabiting relationships (n = 67), and (2) a comparison group of women divorced/separated from non-violent marriages/heterosexual cohabiting relationships (n = 33). The latter group will serve as a control for the stress of divorce/separation. Women will have blood drawn for assessment of basal concentrations of the acute-phase protein high-sensitivity C-reactive protein and the proinflammatory cytokine interleukin-6. lnterleukin-6 production by peripheral blood mononuclear cells in response to in vitro immunological challenge will also be assessed. All women will be interviewed to assess history of victimization, including IPV, and posttraumatic stress symptoms including intrusive re-experiencing. Recent research reveals that older adults' health status is associated with potentially traumatic events experienced decades earlier in adulthood. IPV is endorsed by 25% of adult women in the United States, is a risk factor for posttraumatic stress disorder, and has been associated with prevalence of chronic diseases in several cross-sectional studies. If the proposed hypotheses are supported, they will suggest a plausible basis for linkages among IPV, posttraumatic stress symptoms, and inflammatory conditions associated with aging. One long-term implication would be that evidence-based behavioral interventions that effectively treat posttraumatic stress disorder may also reduce this disorder's contribution to women's risk for developing conditions associated with aging.

描述（由申请人提供）：本研究将测试先前接触过成人亲密伴侣暴力 (IPV) 与炎症标记物和炎症过程之间的关联，这些炎症标记物和过程与多种与衰老相关的疾病（例如心血管疾病、认知能力下降）有关。有人提出，IPV 可能对炎症过程产生长期影响，特别是通过侵入性重新体验的途径（例如，对先前压力事件的反复出现的、不需要的记忆，以及对事件提醒的生理反应）。目标 1 是建立成人 IPV 暴露史与炎症标志物和过程之间的关系。目标 2 是检查 IPV 的严重程度和侵入性重新经历的严重程度如何交互影响炎症标志物和过程。这些目标将在两组刚绝经后的健康女性的横断面研究中得到检验； (1) 从暴力婚姻或异性同居关系中离婚/分居的女性 (n = 67)，以及 (2) 从非暴力婚姻/异性同居关系中离婚/分居的女性对照组 (n = 33)。后一组将作为离婚/分居压力的控制。女性将抽血评估急性时相蛋白、高敏 C 反应蛋白和促炎细胞因子白细胞介素 6 的基础浓度。还将评估外周血单核细胞响应体外免疫挑战而产生的白介素 6。所有女性都将接受采访，以评估受害史（包括 IPV）和创伤后应激症状（包括侵入性重新经历）。最近的研究表明，老年人的健康状况与成年前几十年经历的潜在创伤事件有关。 IPV 得到了 25% 的美国成年女性的认可，它是创伤后应激障碍的危险因素，并且在多项横断面研究中与慢性病的患病率相关。如果所提出的假设得到支持，它们将为 IPV、创伤后应激症状和与衰老相关的炎症状况之间的联系提供合理的基础。一个长期的影响是，有效治疗创伤后应激障碍的循证行为干预措施也可能会减少这种疾病对女性患与衰老相关疾病的风险的影响。