Renal blood flow, vascular stiffness, and the DASH diet

肾血流量、血管僵硬度和 DASH 饮食

基本信息

批准号：
7315772
负责人：
PAUL R CONLIN
金额：
$ 19.35万
依托单位：
BRIGHAM AND WOMEN'S HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-05-01 至 2013-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7315772
关键词：
Academia Acute Address Adherence Admission activity Adrenal Glands Adverse effects Advertisements Affect African American Aldosterone Algorithms Angiotensin II Angiotensin-Converting Enzyme Inhibitors Angiotensinogen Animal Model Anterior Antihypertensive Agents Aorta Apical Applications Grants Area Arginine Arts Asthma Award Awareness Basic Science Behavior Bioinformatics Biometry Bite Blood Pressure Blood Vessels Blood flow Blood specimen Body Surface Body Surface Area Body Weight decreased Boston Calcium Calendar Caliber Captopril Carbohydrates Cardiac Cardiac Output Cardiac Volume Cardiovascular Physiology Cardiovascular system Caring Carotid Arteries Case Management Case Manager Characteristics Chronic Chronic Obstructive Airway Disease Clinical Clinical Data Clinical Investigator Clinical Research Clinical Research Curriculum Award Clinical Sciences Clinical Trials Clinical Trials Cooperative Group Clinical Trials Design Collaborations Commit Communities Complex Computers Condition Consensus Consent Forms Consult Continuous Infusion Control Groups Coronary heart disease Coupled Creatinine Cross-Over Studies Crossover Design Data Data Analyses Data Collection Data Quality Databases Development Devices Diabetes Mellitus Diagnosis Diastole Diastolic blood pressure Diet Dietary Carbohydrates Dietary Intervention Dimensions Diuretics Doctor of Medicine Doctor of Philosophy Dose Drops Eating Education Educational Curriculum Educational process of instructing Educational workshop Effectiveness Effectiveness of Interventions Electrolytes Elements Eligibility Determination Endocrinology Enrollment Ensure Environment Equilibrium Equipment Ethics Evaluation Event Excision Exclusion Criteria Exercise Exposure to Faculty Family history of Fasting Fatty acid glycerol esters Fellowship Program Fertilization Fiber Floor Forearm Fostering Fructosamine Functional disorder Funding Future Gastrointestinal Diseases Generations Genes Genetic Genetic Crossing Over Genetic Polymorphism Genotype Glucose Glycosylated hemoglobin A Goals Grant Group Meetings Guanine Guidelines Health Care Costs Health Personnel Health Services Research Healthcare Systems Heart Heart Atrium Heart Diseases Heart Rate Home environment Hospitalization Hospitals Human Human Genetics Hypercalcemia Hyperglycemia Hypertension Hypocalcemia result Hypokalemia Hypotension Image Imaging technology Individual Industry Infection Inferior Inflammatory Bowel Diseases Information Technology Infusion procedures Instruction Intake Internet Intervention Interview Investigation Isolated systolic hypertension Journals K-Series Research Career Programs Kidney Kidney Diseases Knowledge LDL Cholesterol Lipoproteins Laboratories Lateral Leadership Left Left Ventricular Ejection Fraction Length of Stay Life Style Link Linkage Disequilibrium Lipids Location Lung Macronutrients Nutrition Magnesium Manuscripts Masks Measurement Measures Medical Medical center Medicine Mentors Metabolism Methionine Methodology Methods Micronutrients Mid-Career Clinical Scientist Award (K24)Minority Modeling Modification Monitor Morbidity - disease rate Myocardial National Institute of Diabetes and Digestive and Kidney Diseases Natriuresis Normal Range Numbers Observer Variation Online Systems Operating Rooms Operative Surgical Procedures Organ Outcome Outcome Measure Outpatients Paper Participant Patient Care Patient Recruitments Patients Pattern Peripheral Peripheral Resistance Personal Satisfaction Persons Pharmaceutical Preparations Pharmacology Phenotype Philosophy Physiologic pulse Physiological Physiology Placement Plasma Play Population Control Population Study Positioning Attribute Postoperative Period Potassium Preparation Prevalence Price Procedures Process Process Measure Property Proteins Protocols documentation Provider Public Health Public Health Schools Public Speaking Publications Publishing Pulse taking Purpose Quality of Care Quality of life Race Radial Randomized Range Rate Reader Recording of previous events Recruitment Activity Regulation Relaxation Renal Blood Flow Renin Renin-Angiotensin System Renin-Angiotensin-Aldosterone System Reporting Research Research Design Research Ethics Committees Research Personnel Research Project Grants Research Training Risk Risk Factors Role Running SAS Sample Size Schedule Science Screening procedure Self Management Series Serum Side Sodium Sodium Chloride Solutions Specific qualifier value Staging Standards of Weights and Measures Structure Students Subgroup Supervision Supplementation System Systole Techniques Telephone Test Result Testing Thick Threonine Time Tissues Training Training Programs Transaminases Translating Travel Treatment Protocols Trust Underrepresented Minority United States National Institutes of Health Universities Unsaturated Fats Upper arm Urine Value Meaning Vascular resistance Vasodilation Ventricular Visit Walking Week Woman Work Wound Infection Writing abstracting base blood flow measurement blood glucose regulation blood pressure regulation brachial artery cardiovascular disorder risk cardiovascular risk factor career clinical epidemiology clinically relevant cohort concept cost cost effectiveness data integrity data structure day design drug development editorial electric impedance experience feeding follow-up gene environment interaction glucose monitor good diet health care service utilization heart disease risk hemodynamics human subject hyperkalemia improved indexing interest kidney vascular structure lectures medical schools member men mortality next generation nutrition patient oriented patient oriented research posters pressure prevent programs protocol development quality assurance reactive hyperemia regional difference research and development research study response saluretic saturated fat sex size skills smoking cessation success systolic hypertension tonometry tool two-dimensional volunteer

项目摘要

DESCRIPTION (provided by applicant): This competitive renewal application for a K24 award is to provide support as I (Paul R. Conlin) further my work in patient-oriented research and mentoring of junior investigators. My career has focused on studying mechanisms of blood pressure regulation and more recently, methodologies to improve diabetes care. My long-term goals remain focused on studying lifestyle modification strategies to reduce renal and cardiovascular disease risk factors in patients with hypertension and diabetes through clinical trials. Prior to and during the current award period, I was a co-investigator in three interventional nutrition studies that explored the effects of macro- and micronutrients on blood pressure. As a direct extension of these studies, I am now investigating the effects of the Dietary Approaches to Stop Hypertension (DASH) diet on renal and cardiovascular hemodynamics, to better understand the mechanisms by which the diet lowers blood pressure. In these studies, I am testing the hypothesis that the DASH diet has ACE inhibitor-like effects on renal blood flow, renal and vascular responsiveness to angiotensin II, vascular stiffness, and diastolic function. These studies are being conducted in patients with isolated systolic hypertension. I have also extended my clinical research program to include funded studies at our affiliated VA Medical Center, where I study care management strategies using information technology, to improve blood pressure and glucose control in patients with diabetes mellitus. As a direct result of the protected time afforded by this K24 award, I am mentoring 3 junior investigators (two of whom have career development awards), have accepted a new research fellow to join me in early 2007, and I co-mentor two other individuals. I have assumed a leadership role in the K30-funded "Scholars in Clinical Sciences Program" at Harvard Medical School, serving as Chair of the Mentoring Committee. During the new award period, I will continue with my funded research program and expand the scope of my mentoring, both directly and indirectly through the K30 program. I have a great passion for mentoring junior investigators destined for careers in patient-oriented research, particularly those interested in renal and cardiovascular physiology, interventional nutrition or diabetes care management. With the support of this award, I will make a significant impact on future patient-oriented researchers at multiple levels.

描述（由申请人提供）：这项 K24 奖项的竞争性更新申请旨在为我（Paul R. Conlin）进一步开展以患者为导向的研究和指导初级研究人员提供支持。我的职业生涯主要集中在研究血压调节机制以及最近改善糖尿病护理的方法。我的长期目标仍然集中在研究生活方式改变策略，以通过临床试验减少高血压和糖尿病患者的肾脏和心血管疾病危险因素。在本奖项之前和期间，我是三项介入营养研究的联合研究员，这些研究探讨了大量营养素和微量营养素对血压的影响。作为这些研究的直接延伸，我现在正在研究降血压饮食法 (DASH) 饮食对肾脏和心血管血流动力学的影响，以更好地了解饮食降低血压的机制。在这些研究中，我正在验证以下假设：DASH 饮食对肾血流量、肾脏和血管对血管紧张素 II 的反应性、血管僵硬度和舒张功能具有类似 ACE 抑制剂的作用。这些研究是在患有单纯收缩期高血压的患者中进行的。我还扩展了我的临床研究计划，包括在我们附属的 VA 医疗中心进行的资助研究，在那里我研究使用信息技术的护理管理策略，以改善糖尿病患者的血压和血糖控制。作为 K24 奖项提供的受保护时间的直接结果，我正在指导 3 名初级研究员（其中两人获得职业发展奖），并于 2007 年初接受了一名新研究员加入我，并且我共同指导另外两名研究员个人。我在哈佛医学院 K30 资助的“临床科学学者计划”中担任领导职务，担任指导委员会主席。在新的奖励期间，我将继续我资助的研究项目，并通过 K30 项目直接和间接扩大我的指导范围。我非常热衷于指导初级研究人员从事以患者为导向的研究，特别是那些对肾脏和心血管生理学、介入营养或糖尿病护理管理感兴趣的人。在该奖项的支持下，我将对未来以患者为中心的研究人员产生多个层面的重大影响。