Patient Oriented Research in Vitamin D and Physical Functioning in CKD

以患者为导向的 CKD 维生素 D 和身体机能研究

基本信息

批准号：
7340538
负责人：
Mary Beth Leonard
金额：
$ 16.96万
依托单位：
CHILDREN'S HOSP OF PHILADELPHIA
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-03-01 至 2012-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7340538
关键词：
Address Adult Age Aging Ancillary Study Arts Biometry Body Composition Body Weight decreased Bone Density Calcium Cardiovascular Diseases Child Chronic Kidney Failure Chronic Kidney Insufficiency Clinical Clinical Research Curriculum Award Cohort Studies Commit Comorbidity Condition Control Groups Cross-Sectional Studies Deformity Development Diabetes Mellitus Dialysis patients Dialysis procedure Dimensions Discipline Disease Dual-Energy X-Ray Absorptiometry Endocrinology Environment Epidemiology Equilibrium Estrogens Faculty Fracture Functional disorder Funding Gait Gender Gonadal Steroid Hormones Grant Hospitalization Hyperparathyroidism Hypogonadism Inflammatory Kidney Kidney Diseases Kidney Failure Longitudinal Studies Maintenance Master of Science Measures Mentors Metabolic Bone Diseases Methods Monitor Morbidity - disease rate Muscle Weakness Musculoskeletal National Institute of Diabetes and Digestive and Kidney Diseases Nephrology Outcome Participant Patient Self-Report Patients Pediatric Hospitals Pediatrics Pennsylvania Performance Peripheral Pharmaceutical Preparations Philadelphia Physical Dialysis Physical Function Physical activity Population Porosity Prevalence Prior Therapy Process Protocols documentation Radiology Specialty Randomized Controlled Clinical Trials Rate Renal Osteodystrophy Renal function Research Research Personnel Risk Risk Factors Sclerosis Severities Severity of illness Site Skeletal system Speed Structure Supplementation Thick Time Training Training Programs Universities Visit Vitamin D Vitamin D Deficiency Work X-Ray Computed Tomography bone bone health bone loss bone strength bone turnover calcium metabolism clinical epidemiology cohort data management density disability exhaustion falls frailty gonad function grasp hormone deficiency inorganic phosphate mortality nutrition patient oriented patient oriented research professor prospective retinal rods spine bone structure substantia spongiosa tool

项目摘要

DESCRIPTION (provided by applicant): The applicant is an Associate Professor of Pediatrics in the Division of Nephrology, and an Associate Professor of Epidemiology in the Department of Biostatistics and Epidemiology at the University of Pennsylvania. She is an established clinical researcher with an extensive track record of successful research focused on nutrition and bone health in children and adults with chronic kidney disease (CKD) and inflammatory disorders. The Children's Hospital of Philadelphia and UPENN are committed to providing her with a strong environment for patient-oriented research and mentoring, including multiple institutional training grants, a K30 Clinical Research Curriculum Award, an extraordinarily successful Master's of Science in Clinical Epidemiology training program, biostatistical and data management support, and state of the art methods for the assessment of bone structure and body composition. One of her current patient-oriented, NIDDK-funded R01s is a prospective cohort study of bone structure in 325 adults with CKD and 500 controls. Fracture risk is markedly increased in CKD and is associated with substantial morbidity. This study is examining the effects of renal disease severity, hypogonadism, hyperparathyroidism, comorbid conditions and medications on bone density and structure as assessed by quantitative computed tomography. Numerous studies have demonstrated that vitamin D deficiency in the absence of CKD is associated with muscle weakness. Patients with CKD have numerous risk factors for vitamin D deficiency. Dialysis patients suffer increased fall and fracture rates and severely limited physical function. The relations between vitamin D [25(OH)D and 1,25(OH)2D] and PTH levels and physical function have not been examined in CKD. This application proposes an ancillary study of vitamin D levels and physical performance within her CKD cohort, adding validated, standardized measures of physical performance (gait speed, standing balance, timed sit- to-stand) and frailty (involuntary weight loss, self-reported exhaustion, low physical activity, grip strength and gait speed) that predicted falls, disability, hospitalizations and mortality in varied populations. Vitamin D deficiency likely contributes to the substantial burden of musculoskeletal complications of CKD. Delineation of the relations between vitamin D levels and physical functioning outcomes is necessary in order to develop anticipated randomized trials of vitamin D supplementation in CKD.

描述（由申请人提供）：申请人是肾脏科学科儿科学副教授，也是宾夕法尼亚大学生物统计学和流行病学系流行病学副教授。她是一位知名的临床研究人员，在慢性肾脏疾病（CKD）和炎症性疾病的儿童和成人中，成功研究的成功研究有广泛的记录。 The Children's Hospital of Philadelphia and UPENN are committed to providing her with a strong environment for patient-oriented research and mentoring, including multiple institutional training grants, a K30 Clinical Research Curriculum Award, an extraordinarily successful Master's of Science in Clinical Epidemiology training program, biostatistical and data management support, and state of the art methods for the assessment of bone structure and body composition.她目前以患者为导向的NIDDK资助的R01S之一是对325名CKD成年人和500个对照组的骨骼结构的前瞻性队列研究。 CKD中的断裂风险明显增加，并且与大量发病有关。这项研究正在研究肾脏疾病严重程度，性能不良，甲状旁腺功能亢进症，合并症和药物对骨密度和结构的影响，如定量计算机断层扫描所评估。许多研究表明，在没有CKD的情况下，维生素D缺乏与肌肉无力有关。 CKD患者具有多种维生素D缺乏症的危险因素。透析患者跌倒和骨折率增加，身体机能严重限制。在CKD中尚未检查维生素D [25（OH）D和1,25（OH）2D]与PTH水平和身体功能之间的关系。该应用提出了一项辅助研究对她的CKD队列中维生素D水平和身体性能的辅助研究，并增加了经过验证的，标准化的身体性能度量（步态速度，站立平衡，定时坐姿）和脆弱（非自愿体重，自我报告，自我报告的疲惫，体力劳动低，身体活动低，抓地力和GAIT速度），预测的跌倒，不可落下，不可降低，住院，住院和多种多样。维生素D缺乏可能会导致CKD肌肉骨骼并发症的重大负担。为了开发CKD中维生素D补充的预期随机试验，必须描述维生素D水平与身体功能结果之间的关系。