Computational modeling of hemodynamics in cerebral aneurysms

脑动脉瘤血流动力学的计算模型

• 批准号: 7470873
• 负责人: Vitaliy L Rayz
• 金额: $ 11.37万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7470873
• 关键词: Accounting; Aneurysm; Angiography; Arts; Behavior; Blood; Blood Clot; Blood Platelets; Blood Vessels; Blood Viscosity; Blood coagulation; Blood flow; Cerebral Aneurysm; Cerebrum; Cessation of life; Class; Classification; Clinical; Clinical Data; Clip; Complement; Complex; Computer Simulation; Computing Methodologies; Condition; Data; Decision Making; Deposition; Descriptor; Development; Dimensions; Disease; Doctor of Philosophy; Endothelial Cells; Ensure; Equation; Erythrocytes; Evaluation; Face; Foundations; Goals; Growth; Hand; Heart; Hemorrhage; Image; Imagery; In Vitro; Individual; Injury; Intervention; Intracranial Aneurysm; Investigation; Lead; Link; Liquid substance; Location; Longitudinal Studies; Measurement; Medical Imaging; Medical Research; Methods; Modality; Modeling; Numbers; Operative Surgical Procedures; Outcome; Patients; Pattern; Physics; Physiologic pulse; Physiological; Physiology; Process; Public Health; Pulsatile Flow; Pulse taking; Range; Research; Research Personnel; Resolution; Risk; Risk Estimate; Role; Rupture; Simulate; Societies; Solid; Surface; Symptoms; Therapeutic; Thrombus; Training; Uncertainty; Universities; Variant; Vascular Diseases; Velocimetries; Work; base; hemodynamics; improved; in vitro Model; in vivo; insight; interest; pressure; programs; shear stress; simulation; size; tool

DESCRIPTION (provided by applicant): This project is aimed at developing new simulation capabilities for elucidating the hemodynamics in intracranial aneurysms. Successful completion of this project will create a systematic and methodical approach to the determination of function in intracranial aneurysms and will provide important new guidance to clinicians as they develop strategies to treat these disorders. The specific aims of these projects are therefore: 1) To determine the impact of experimental imprecision in the specification of CFD models on the computed velocity fields 2) To develop CFD modeling capabilities for predicting regions of intra-luminal thrombus deposition 3) To initiate numerical simulations of flow in a number of patient-specific cerebral aneurysm geometries and initiate a study of the role of hemodynamic descriptors in aneurysm progression. Current advances in medical imaging and computational methods provide an opportunity to use numerical modeling for investigation of the flow in intracranial aneurysms on a patient-specific basis. We propose to combine the state of the art medical imaging with 3D visualization and computational fluid dynamics methods to accurately capture the flow physics and its implications on the aneurysm progression. The objective of this project is to develop a CFD tool for estimating the velocity field in aneurysmal vessels in vivo, and to establish the range of validity of that tool. Relevance to public health: This proposal aims to develop computational methods for assessing blood flow patterns within cerebral aneurysms. These developments will provide the tools needed to determine the impact of flow-related forces to the progression of aneurysmal disease. They will also provide the ability to predict the likely outcome of different surgical interventions, and will provide clinicians with the ability to determine the most effective strategy for treating these disorders. The ability to simulate blood flow patterns in intracranial aneurysms should provide new insights into the underlying physiology that causes some aneurysms to remain stable, and others to grow, resulting in profound symptoms or rupture with a high likelihood of devastating cerebral injury or death.

描述（由申请人提供）：该项目旨在开发新的模拟功能，以阐明颅内动脉瘤的血流动力学。该项目的成功完成将为确定颅内动脉瘤的功能创建系统且有条理的方法，并将为临床医生制定治疗这些疾病的策略提供重要的新指导。因此，这些项目的具体目标是： 1) 确定 CFD 模型规范中的实验不精确对计算速度场的影响 2) 开发 CFD 建模功能以预测腔内血栓沉积区域 3) 启动数值计算模拟许多患者特定的脑动脉瘤几何形状中的血流，并启动了血流动力学描述符在动脉瘤进展中的作用的研究。当前医学成像和计算方法的进步提供了使用数值模型根据患者具体情况研究颅内动脉瘤血流的机会。我们建议将最先进的医学成像与 3D 可视化和计算流体动力学方法相结合，以准确捕获流动物理学及其对动脉瘤进展的影响。该项目的目标是开发一种 CFD 工具，用于估计体内动脉瘤血管的速度场，并确定该工具的有效性范围。与公共卫生的相关性：该提案旨在开发用于评估脑动脉瘤内血流模式的计算方法。这些进展将提供确定血流相关力对动脉瘤疾病进展的影响所需的工具。它们还将提供预测不同手术干预的可能结果的能力，并使临床医生能够确定治疗这些疾病的最有效策略。模拟颅内动脉瘤血流模式的能力应该为了解导致某些动脉瘤保持稳定而另一些动脉瘤生长的潜在生理学提供新的见解，从而导致严重的症状或破裂，极有可能造成毁灭性的脑损伤或死亡。