Long-term changes in weight and adipokines and the associations with genetic vari

体重和脂肪因子的长期变化及其与遗传变异的关系

• 批准号: 7447527
• 负责人: LORA Emilie BURKE
• 金额: $ 12.86万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7447527
• 关键词: Address; Adipose tissue; Adopted; Adult; Anti-Inflammatory Agents; Anti-inflammatory; Archives; Area; Atherosclerosis; Behavior; Behavior Therapy; Behavioral; Behavioral Model; Behavioral Sciences; Biological; Biological Factors; Body Weight Changes; Body Weight decreased; Cardiovascular Diseases; Chronic Disease; Conduct Clinical Trials; Development; Diabetes Mellitus; Disease; Energy Intake; Energy Metabolism; Expenditure; Faculty; Failure; Functional disorder; Genes; Genetic; Genetic Variation; Health; Healthcare; Hormones; Individual; Inflammation; Inflammatory; Insulin; Insulin Resistance; Interleukin-10; Interleukin-6; Intervention; Investigation; Knowledge; Lead; Leptin; Link; Literature; Maintenance; Measurement; Measures; Mentors; Mentorship; Metabolic syndrome; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Numbers; Obesity; Overweight; Participant; Pattern; Plasma; Population; Process; Purpose; Randomized Clinical Trials; Reporting; Research; Resistance development; Risk; Role; Sampling; Serum; Specimen; Students; Technology; Tumor Necrosis Factor-alpha; Variant; Visit; Weight; Weight Gain; Woman; Work; adipokines; adiponectin; biobehavior; cohort; ghrelin; improved; insulin sensitivity; men; multidisciplinary; new technology; prevent; programs; vascular inflammation; weight loss intervention

DESCRIPTION (provided by applicant): Nearly 46% of women and 33% of men report attempts to lose weight. However, weight cycling - intentional weight loss followed by regain of at least 10Ibs. - occurs in approximately 80% of adults who lose weight; 50% of the weight regain occurs within a year. A major focus of the candidate's research is on behavioral and technological strategies to improve long-term weight loss maintenance. With the support of the Midcareer Investigator Award in Patient-Oriented Research (K24), the candidate will expand this focus to an investigation of the biobehavioral processes involved in the failure to maintain a loss and the subsequent weight regain. The proposed study will build on an ongoing randomized clinical trial (SMART study) and collect specimens every 6 months during the 24-month behavioral, weight loss intervention so that the candidate and her multidisciplinary team can prospectively study the subset of individuals who lose and regain at least 10Ibs. during the study. The study's 3 aims are: (1) describe the patterns of weight loss and regain from baseline to 24 months and their effect on insulin resistance (plasma insulin), adipokines (TNFalpha, IL-6, adiponectin, IL-10), and ghrelin and leptin; (2) describe the behaviors related to energy intake and energy expenditure and explore their temporal associations with weight loss and weight gain; and (3) explore whether variation in genes implicated in weight change are related to change in serum level of adipokines and to the behaviors related to weight loss and regain. The mentorship plan will focus on the candidate (PI) and a multidisciplinary cadre of mentees who have been working with her. With the support of the K24 Award, Dr. Burke will work with an interdisciplinary team to advance her knowledge of the inflammatory processes that may occur with weight regain, which may provide the link between obesity, insulin resistance, atherosclerosis and cardiovascular disease; additionally, she will focus on the possible role of genetics in these biobehavioral processes. She will use her ongoing studies to mentor students, fellows and junior faculty on the development of behavioral interventions, the use of technology in interventions and measurement, the conduct of clinical trials, and the role of inflammation and genetics in weight loss and regain. She will develop a mentoring program that follows NINR's strategies for integrating biological and behavioral science for better health, and adopting new technologies for better health care. The proposed study and mentoring strategies will be placed in the context of an area of NINR emphasis - promoting health and preventing disease as it addresses a highly prevalent chronic disorder - overweight and obesity.

描述（由申请人提供）：近 46% 的女性和 33% 的男性表示曾尝试减肥。然而，体重循环——有意减轻体重，然后体重恢复至少 10 磅。 - 大约 80% 的减肥成年人都会发生这种情况； 50%的体重反弹发生在一年内。候选人研究的一个主要重点是改善长期减肥维持的行为和技术策略。在以患者为导向的研究中职业生涯调查员奖（K24）的支持下，候选人将把这一重点扩展到对无法维持减肥和随后体重反弹所涉及的生物行为过程的调查。拟议的研究将建立在一项正在进行的随机临床试验（SMART 研究）的基础上，并在 24 个月的行为减肥干预期间每 6 个月收集一次样本，以便候选人和她的多学科团队能够前瞻性地研究减重和恢复的个体子集至少 10 磅。在学习期间。该研究的 3 个目标是：(1) 描述从基线到 24 个月的体重减轻和恢复模式及其对胰岛素抵抗（血浆胰岛素）、脂肪因子（TNFα、IL-6、脂联素、IL-10）和生长素释放肽的影响和瘦素； （2）描述与能量摄入和能量消耗相关的行为，并探讨它们与体重减轻和体重增加的时间关联； (3)探讨与体重变化有关的基因变异是否与血清脂肪因子水平的变化以及与体重减轻和体重增加相关的行为有关。导师计划将重点关注候选人（PI）和一直与她一起工作的多学科受训者骨干。在 K24 奖的支持下，Burke 博士将与一个跨学科团队合作，加深对体重反弹可能发生的炎症过程的了解，这可能会提供肥胖、胰岛素抵抗、动脉粥样硬化和心血管疾病之间的联系；此外，她将重点关注遗传学在这些生物行为过程中可能发挥的作用。她将利用她正在进行的研究来指导学生、研究员和初级教师开发行为干预措施、在干预和测量中使用技术、进行临床试验，以及炎症和遗传学在减肥和体重恢复中的作用。她将制定一个指导计划，遵循 NINR 的战略，即整合生物和行为科学以改善健康，并采用新技术以改善医疗保健。拟议的研究和指导策略将置于 NINR 重点领域的背景下——促进健康和预防疾病，因为它解决了一种高度流行的慢性疾病——超重和肥胖。