Reducing Transmission of Influenza by Face Masks

减少口罩传播流感

• 批准号: 7266651
• 负责人: ARNOLD S MONTO
• 金额: $ 110.1万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-30 至 2008-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7266651
• 关键词: antiseptic sterilization; clinical research; clinical trials; communicable disease control; communicable disease diagnosis; communicable disease transmission; cooperative study; disease /disorder proneness /risk; disease outbreaks; health behavior; health education; human subject; influenza; questionnaires; surgery material /equipment; university student

DESCRIPTION (provided by applicant): The effectiveness in reducing influenza occurrence with use of face masks worn alone, or layered with hand hygiene will be evaluated in a randomized intervention. The study will be carried out among University of Michigan students living in University housing. Randomization will be by housing unit. In the first year, 750 students will be recruited to use face masks alone, 750 will use face masks and hand hygiene, and 750 will serve as an observed comparison group. Total number of participants will 2,250. Two small dormitories, 6 larger ones, and one complex with 10 component units have been identified as suitable for the study. Students living in each of the residence halls will be asked if they wish to participate in the study. Those giving informed consent will be asked to complete a survey each week to ascertain illness occurrence. When influenza illness is documented to be occurring in the University setting, the interventions will be implemented. During that period, the survey will be expanded to include questions on intervention use, as appropriate to the particular housing unit. Also during this period, those with illnesses meeting a case definition will be asked to provide specimens for the virus identification. This collection will not be limited to those agreeing to the use of the interventions. All living in the participating housing units will be eligible, after they give informed consent. With this sample size, it will be possible to detect a 40% reduction between those in an intervention group and the control group. Such a reduction could have a major public health impact during a pandemic. In the second year, the study can be expanded or modified based on findings in the first.

描述（由申请人提供）：将在随机干预中评估单独佩戴口罩或与手部卫生分层使用口罩减少流感发生的有效性。该研究将在住在大学宿舍的密歇根大学学生中进行。随机分组将按住房单元进行。第一年，将招募750名学生单独使用口罩，750名学生使用口罩和手部卫生，750名学生作为观察对照组。参加者总数为2,250人。两栋小型宿舍、六栋较大的宿舍以及一栋由 10 个组成单元组成的综合体已被确定适合该研究。居住在每个宿舍的学生都会被询问是否愿意参加该研究。那些给予知情同意的人将被要求每周完成一项调查，以确定疾病的发生情况。当流感疾病被记录在大学环境中发生时，将实施干预措施。在此期间，调查将根据特定住房单元的情况扩大到包括有关干预措施使用的问题。同样在此期间，那些患有符合病例定义的疾病的人将被要求提供样本以进行病毒鉴定。该收集不仅限于那些同意使用干预措施的人。所有居住在参与住房单元的人在知情同意后都有资格。在这个样本量下，可以检测到干预组和对照组之间减少了 40%。在大流行期间，这种减少可能会对公共卫生产生重大影响。第二年，研究可以根据第一年的研究结果进行扩展或修改。