Biomechanical Properties of the Transverse Carpal Ligament

腕横韧带的生物力学特性

• 批准号: 7460818
• 负责人: Zong-Ming Li
• 金额: $ 7.28万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7460818
• 关键词: Activities of Daily Living; American; Behavior; Biomechanics; Biomedical Engineering; Carpal Tunnel Syndrome; Clinical Trials; Computer Simulation; Condition; Data; Development; Disease; Elements; Etiology; General Population; Goals; Hand; Health Care Costs; Invasive; Investigation; Knowledge; Ligaments; Mechanics; Methods; Modeling; Operative Surgical Procedures; Pathogenesis; Play; Prevalence; Prevention strategy; Principal Investigator; Procedures; Productivity; Property; Public Health; Recurrence; Research; Residual state; Role; Specimen; Standards of Weights and Measures; Stretching; Techniques; Testing; United States; Validation; improved; morphometry; novel; programs; tool

DESCRIPTION (provided by applicant): Carpal tunnel syndrome (CTS) is the most prominent hand disorder and has an immense negative impact on national health care cost, worker productivity, and activities of daily living. Despite its increasing prevalence and public health burden, our understanding of CTS is rather limited and our treatment to CTS awaits improvement. The objective of this project is to elucidate the mechanical properties of the transverse carpal ligament (TCL), to comprehend the implication of TCL mechanics to CTS, and to use our findings to guide the development of alternative CTS treatments. We will achieve the objective using complementary experimental and theoretical approaches. Experimentally, we will investigate the material properties of the TCL and the structural properties of the carpal tunnel using cadaveric specimens. The experimental data will allow for the creation and validation of a finite element model of the carpal tunnel. The validated model will provide a valuable tool for the prediction of carpal tunnel mechanics and pathomechanics under numerous anatomical configurations and biomechanical boundary conditions. Our central hypothesis is that the mechanics of the TCL can be exploited for the development of a minimally invasive surgical treatment of CTS. Specifically, we will test the hypotheses that the carpal tunnel can be substantially expanded by stretching the TCL without compromising the structural integrity of the carpal tunnel, and that permanent residual expansion of the carpal tunnel can be obtained after an extended period of loading on the TCL. The specific aims of this project are (1) to characterize the material properties of the TCL by tensile testing, (2) to examine the expansion and creep behaviors of the carpal tunnel by stretching the TCL from within the carpal tunnel, and (3) to establish a computational model for the determination of carpal tunnel morphometry under various anatomical configurations and loading conditions. Our study represents a novel bioengineering approach to an enhanced management of CTS. The results of our investigation will aid the discovery of alternative pathogeneses of CTS, and the development of alternative treatments of CTS. Our long-term goal is to scientifically understand the mechanics and pathomechanics of the carpal tunnel entity and its relevance to CTS, and help provide strategies for the prevention, assessment, and treatment of CTS.

描述（由申请人提供）： 腕管综合征（CTS）是最突出的手部疾病，对国家医疗保健成本，工人生产力和日常生活的负面影响巨大。尽管普遍存在和公共卫生负担不断增加，但我们对CTS的理解是有限的，我们对CTS的治疗正在等待改善。 该项目的目的是阐明横向腕韧带（TCL）的机械性能，以理解TCL力学对CTS的影响，并使用我们的发现来指导替代CTS处理的开发。我们将使用互补的实验和理论方法实现目标。在实验上，我们将使用尸体标本研究TCL的材料特性和腕管的结构特性。实验数据将允许创建和验证腕管的有限元模型。经过验证的模型将为在众多解剖结构和生物力学边界条件下预测腕管机械和致病力学的预测提供有价值的工具。我们的中心假设是，可以利用TCL的力学来开发CTS的微创手术治疗。具体而言，我们将测试假设可以通过伸展TCL而不损害腕管的结构完整性来大大扩展腕管的假设，并且在TCL上延长载荷后，可以获得腕管的永久残留膨胀。该项目的具体目的是（1）通过拉伸测试来表征TCL的材料特性，（2）通过将TCL从腕管内部拉伸，以及（3）来检查腕管的膨胀和蠕变行为，以建立一个计算模型，以确定各种腕管的腕管和加载条件下的腕管形态。 我们的研究代表了一种新型的生物工程方法来增强CT的管理。我们的调查结果将有助于发现CTS的替代病原体，以及CTS替代治疗的发展。我们的长期目标是科学地了解腕管实体的机制和病理学及其与CTS的相关性，并有助于为CTS的预防，评估和治疗提供策略。