Hand Sensorimotor Function and Carpal Tunnel Syndrome

手感觉运动功能和腕管综合症

基本信息

批准号：
8249044
负责人：
Zong-Ming Li
金额：
$ 35.33万
依托单位：
CLEVELAND CLINIC LERNER COM-CWRU
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-04-01 至 2015-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8249044
关键词：
Abnormal coordination Affect Algorithms Behavioral Mechanisms Biomechanics Carpal Tunnel Syndrome Carpometacarpal joint structure Chronic Classification Clinical Coupling Data Development Disease Drops Electroencephalography Electromyography Exertion Eye Fingers Hand Health Care Costs Health Personnel High Prevalence Human Individual Joints Lasso Machine Learning Manuals Measures Median Neuropathy Metacarpophalangeal joint structure Methodology Methods Modeling Motor Motor Cortex Neural Conduction Neuraxis Neuromuscular Diseases Neuropathy Patients Performance Peripheral Peripheral Nervous System Diseases Production Productivity Pronation Public Health Quality of life Questionnaires Reaction Rehabilitation therapy Reproducibility Research Response Latencies Sensorimotor functions Sensory Techniques Testing Thumb structure Time Translational Research Trees Validation Wrist data mining diagnosis evaluation experience grasp improved indexing median nerve motor control neurophysiology novel programs public health relevance research study response stretch reflex tool vector

项目摘要

DESCRIPTION (provided by applicant): The median nerve is susceptible to compression in the wrist, leading to carpal tunnel syndrome (CTS). CTS is the most common compression neuropathy and have an immense impact on national health care, worker productivity, and quality of life. Despite its high prevalence and public health cost, our understanding of CTS is limited, and the management of CTS awaits improvement. The central notion of this project is that hand sensorimotor function is sensitive to peripheral median neuropathy and that the central nervous system is affected by CTS, causing the associated sensorimotor deficit. We will investigate this notion with quantifiable sensorimotor data from novel biomechanical and neurophysiological studies. This project has three aims consisting of biomechanical, neurophysiological and translational research. The first aim is to investigate CTS-induced pathokinematic and pathokinetic performance using dexterous manual tasks of thumb opposition, reach-to-pinch, precision grip, and finger pressing. The second aim is to investigate the neurophysiological implications of chronic peripheral neuropathy (i.e., CTS) on the central nervous system by evaluating corticomuscular coupling and stretch reflex. The third aim is to identify novel biomechanical and neurophysiological markers for CTS cases using machine learning and classification algorithms. The results of this project will elucidate the pathological mechanisms and behavioral manifestations of CTS and aid in the development of new strategies for diagnosis, evaluation, rehabilitation, and treatment of this disorder. More generally, CTS as a chronic neuropathy serves as an effective model to study sensorimotor mechanisms of the peripheral and central nervous systems. In addition, the methodology developed in this project is applicable to other neuromuscular disorders. PUBLIC HEALTH RELEVANCE: Carpal tunnel syndrome is highly prevalent and costly. One of the distinct consequences of carpal tunnel syndrome is that patients experience inexplicable dropping of objects and clumsiness while performing simple daily tasks. In this project, we propose to study the sensorimotor deficit using novel biomechanical and neurophysiological experiments. The results of this project will elucidate the pathological mechanisms and manifestations of carpal tunnel syndrome. This project is clinically translational to aid in the development of new strategies for diagnosis, evaluation, rehabilitation, and treatment of this disorder.

描述（由申请人提供）：正中神经容易受到手腕的压迫，导致腕管综合症（CTS）。 CTS 是最常见的压迫性神经病，对国家医疗保健、工人生产力和生活质量产生巨大影响。尽管其患病率和公共卫生成本较高，但我们对CTS的了解有限，CTS的管理有待改进。该项目的核心概念是手部感觉运动功能对周围正中神经病变敏感，并且中枢神经系统受到 CTS 的影响，导致相关的感觉运动缺陷。我们将利用来自新颖的生物力学和神经生理学研究的可量化的感觉运动数据来研究这一概念。该项目有三个目标，包括生物力学、神经生理学和转化研究。第一个目标是利用拇指对立、伸手捏捏、精确抓握和手指按压等灵巧的手动任务来研究 CTS 引起的病理运动学和病理运动学表现。第二个目标是通过评估皮质肌肉耦合和牵张反射来研究慢性周围神经病（即 CTS）对中枢神经系统的神经生理学影响。第三个目标是使用机器学习和分类算法识别 CTS 病例的新型生物力学和神经生理学标记。该项目的结果将阐明 CTS 的病理机制和行为表现，并有助于制定诊断、评估、康复和治疗这种疾病的新策略。更一般地说，CTS 作为一种慢性神经病，可作为研究周围和中枢神经系统感觉运动机制的有效模型。此外，该项目开发的方法适用于其他神经肌肉疾病。公众健康相关性：腕管综合症非常普遍且昂贵。腕管综合症的明显后果之一是患者在执行简单的日常任务时会出现莫名其妙的物体掉落和笨拙的情况。在这个项目中，我们建议使用新颖的生物力学和神经生理学实验来研究感觉运动缺陷。该项目的结果将阐明腕管综合征的病理机制和表现。该项目具有临床转化意义，有助于开发诊断、评估、康复和治疗这种疾病的新策略。