Hand Sensorimotor Function and Carpal Tunnel Syndrome

手感觉运动功能和腕管综合症

• 批准号: 8249044
• 负责人: Zong-Ming Li
• 金额: $ 35.33万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8249044
• 关键词: Abnormal coordination; Affect; Algorithms; Behavioral Mechanisms; Biomechanics; Carpal Tunnel Syndrome; Carpometacarpal joint structure; Chronic; Classification; Clinical; Coupling; Data; Development; Disease; Drops; Electroencephalography; Electromyography; Exertion; Eye; Fingers; Hand; Health Care Costs; Health Personnel; High Prevalence; Human; Individual; Joints; Lasso; Machine Learning; Manuals; Measures; Median Neuropathy; Metacarpophalangeal joint structure; Methodology; Methods; Modeling; Motor; Motor Cortex; Neural Conduction; Neuraxis; Neuromuscular Diseases; Neuropathy; Patients; Performance; Peripheral; Peripheral Nervous System Diseases; Production; Productivity; Pronation; Public Health; Quality of life; Questionnaires; Reaction; Rehabilitation therapy; Reproducibility; Research; Response Latencies; Sensorimotor functions; Sensory; Techniques; Testing; Thumb structure; Time; Translational Research; Trees; Validation; Wrist; data mining; diagnosis evaluation; experience; grasp; improved; indexing; median nerve; motor control; neurophysiology; novel; programs; public health relevance; research study; response; stretch reflex; tool; vector

DESCRIPTION (provided by applicant): The median nerve is susceptible to compression in the wrist, leading to carpal tunnel syndrome (CTS). CTS is the most common compression neuropathy and have an immense impact on national health care, worker productivity, and quality of life. Despite its high prevalence and public health cost, our understanding of CTS is limited, and the management of CTS awaits improvement. The central notion of this project is that hand sensorimotor function is sensitive to peripheral median neuropathy and that the central nervous system is affected by CTS, causing the associated sensorimotor deficit. We will investigate this notion with quantifiable sensorimotor data from novel biomechanical and neurophysiological studies. This project has three aims consisting of biomechanical, neurophysiological and translational research. The first aim is to investigate CTS-induced pathokinematic and pathokinetic performance using dexterous manual tasks of thumb opposition, reach-to-pinch, precision grip, and finger pressing. The second aim is to investigate the neurophysiological implications of chronic peripheral neuropathy (i.e., CTS) on the central nervous system by evaluating corticomuscular coupling and stretch reflex. The third aim is to identify novel biomechanical and neurophysiological markers for CTS cases using machine learning and classification algorithms. The results of this project will elucidate the pathological mechanisms and behavioral manifestations of CTS and aid in the development of new strategies for diagnosis, evaluation, rehabilitation, and treatment of this disorder. More generally, CTS as a chronic neuropathy serves as an effective model to study sensorimotor mechanisms of the peripheral and central nervous systems. In addition, the methodology developed in this project is applicable to other neuromuscular disorders. PUBLIC HEALTH RELEVANCE: Carpal tunnel syndrome is highly prevalent and costly. One of the distinct consequences of carpal tunnel syndrome is that patients experience inexplicable dropping of objects and clumsiness while performing simple daily tasks. In this project, we propose to study the sensorimotor deficit using novel biomechanical and neurophysiological experiments. The results of this project will elucidate the pathological mechanisms and manifestations of carpal tunnel syndrome. This project is clinically translational to aid in the development of new strategies for diagnosis, evaluation, rehabilitation, and treatment of this disorder.

描述（由申请人提供）：中位神经容易受到腕部压缩的影响，导致腕管综合征（CTS）。 CTS是最常见的压缩神经病，对国家医疗保健，工人生产力和生活质量产生了巨大影响。尽管患病率很高和公共卫生成本，但我们对CTS的理解是有限的，并且对CTS的管理正在等待改进。该项目的中心概念是手动感应功能对外周中位神经病敏感，并且中枢神经系统受CTS的影响，从而导致相关的感觉运动缺陷。我们将使用新的生物力学和神经生理学研究中的可量化的感觉运动数据来研究这个概念。该项目的三个目标包括生物力学，神经生理和转化研究。第一个目的是使用拇指对立的灵巧手动任务，触手可及，精密握把和手指按压，研究CTS诱导的病理学和病理性能。第二个目的是通过评估皮质肌肉肌偶联和伸展反射，研究中枢神经系统对慢性周围神经病（即CTS）的神经生理意义。第三个目的是使用机器学习和分类算法来确定CTS病例的新型生物力学和神经生理标记。该项目的结果将阐明CTS的病理机制和行为表现，并有助于制定该疾病的诊断，评估，康复和治疗的新策略。更一般而言，作为慢性神经病的CTs是研究周围和中枢神经系统的感觉运动机制的有效模型。此外，该项目中开发的方法适用于其他神经肌肉疾病。 公共卫生相关性：腕管综合症高度普遍且昂贵。腕管综合症的明显后果之一是，在执行简单的日常任务时，患者在对象和笨拙的同时经历了莫名其妙的掉落。在这个项目中，我们建议使用新型的生物力学和神经生理实验研究感觉运动不足。该项目的结果将阐明腕管综合征的病理机制和表现。该项目在临床上是有助于制定新诊断，评估，康复和治疗该疾病的新策略。