Adherence Among Older Women with Breast Cancer

患有乳腺癌的老年女性的依从性

基本信息

批准号：
7447892
负责人：
SHARON Hermes GIORDANO
金额：
$ 13.61万
依托单位：
UNIVERSITY OF TX MD ANDERSON CAN CTR
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-07-01 至 2010-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7447892
关键词：
Address Adherence Adjuvant Adjuvant Chemotherapy Adjuvant Radiotherapy Adjuvant Therapy Affect Breast Cancer Treatment Cancer Patient Caring Characteristics Cognition Communities Comorbidity Condition Data Data Analyses Data Collection Databases Dementia Development Diagnosis Disease Effectiveness Ensure Ethnic Origin Geography Goals Health Services Intervention K-Series Research Career Programs Knowledge Link Medical Oncologist Medicare Mental Depression Mentors Motivation Operative Surgical Procedures Oral Outcome Patient Noncompliance Patients Pattern Physicians Population Practice Guidelines Prospective Studies Qualifying Radiation therapy Randomized Clinical Trials Reading Research Research Personnel Risk Sampling Socioeconomic Status Standards of Weights and Measures Therapeutic Clinical Trial Training Treatment Protocols United States Woman base career chemotherapy compliance behavior experience hormone therapy improved malignant breast neoplasm mortality neoplasm registry older women skills statistics

项目摘要

DESCRIPTION (provided by applicant): The objective of this career development award is to provide Dr. Sharon Giordano with the experience and knowledge necessary to become an independent health services researcher in the field of breast cancer. Dr. Giordano, who is a medical oncologist and MPH candidate, will accomplish this goal through a combination of directed reading, seminars, coursework, and mentored research. A highly qualified team of mentors will supervise her training and ensure that she meets her goals. Dr. Giordano will be examining adherence to a standard course of adjuvant treatment among older women with breast cancer using two different approaches: secondary data analyses using the SEER-Medicare database and primary data collection. The specific aims of this proposal are: 1 ) to describe lack of adherence to chemotherapy and radiotherapy in a population-based sample of older women with breast cancer; 2) to determine the effect of specific comorbidities as well as patient, physician, and environmental characteristics on adherence to chemotherapy and radiotherapy; and 3) to prospectively identify factors, including the potentially unrecognized comorbidities of depression and dementia, that affect adherence to therapy in older women with breast cancer. The first two specific aims will be accomplished using the population-based SEER-Medicare database, and the third specific aim through a prospective study. The proposed research will provide important knowledge regarding the patterns and predictors of adherence to adjuvant therapy among older women. In addition, these studies will provide the applicant with expertise in the use of cancer registry data and claims data, in primary data collection, and in data analysis. The proposed studies and career development activities will provide the applicant with the skills to develop into an independent investigator.

描述（由申请人提供）：该职业发展奖的目的是为Sharon Giordano博士提供成为乳腺癌领域独立卫生服务研究人员所必需的经验和知识。乔丹诺（Giordano）博士是一名医学肿瘤学家和MPH候选人，将通过有指导性阅读，研讨会，课程和指导研究的结合来实现这一目标。一个高素质的导师团队将监督她的培训，并确保她达到目标。乔丹诺博士将使用两种不同的方法来检查老年妇女对辅助治疗的标准疗程：使用SEER-MEDICARE数据库和主要数据收集的二级数据分析。这个特定的目的提案是：1）描述在乳腺癌老年妇女的基于人群的样本中缺乏对化学疗法和放疗的缺乏； 2）确定特定合并症以及患者，医师和环境特征对化学疗法和放疗的影响； 3）为了确定影响老年乳腺癌妇女依从性治疗的潜在抑郁和痴呆合并症，包括可能无法识别的抑郁和痴呆合并症。前两个具体目标将使用基于人群的SEER-MEDICARE数据库以及前瞻性研究的第三个特定目的来实现。拟议的研究将提供有关老年妇女遵守辅助治疗的模式和预测指标的重要知识。此外，这些研究将为申请人提供癌症注册表数据和索赔数据，主要数据收集和数据分析方面的专业知识。拟议的研究和职业发展活动将为申请人提供发展为独立研究者的技能。