Developing a culturally tailored mHealth symptom monitoring intervention to improve adherence to endocrine therapy among Black women with breast cancer

开发适合文化的移动健康症状监测干预措施，以提高患有乳腺癌的黑人女性对内分泌治疗的依从性

• 批准号: 10642274
• 负责人: Kimberley T Lee
• 金额: $ 28.46万
• 依托单位: H. LEE MOFFITT CANCER CTR & RES INST
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-18 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10642274
• 关键词: Address; Adherence; Behavior Therapy; Biological; Black Populations; Black race; Breast Cancer survivor; Cancer Center; Cancer Survivor; Cancer Survivorship; Caring; Cessation of life; Clinical; Clinical Research; Comprehension; Consent; Control Groups; Data; Daughter; Department chair; Development; Development Plans; Discipline; Disparity; Educational Materials; Educational workshop; Eligibility Determination; Encapsulated; Ensure; Environment; Epidemiologic Methods; Epidemiology; Feedback; Foundations; Funding; Future; Goals; Health Technology; High Risk Woman; Institution; Intervention; Interview; Life; Malignant Neoplasms; Measures; Mentorship; Methods; Minority; Modeling; Monitor; Observational epidemiology; Oncology; Outcome; Participant; Pathway interactions; Patients; Pharmaceutical Preparations; Phase; Pilot Projects; Population; Population Sciences; Positioning Attribute; Preparation; Provider; Publishing; Qualitative Methods; Quality of life; Randomized; Randomized, Controlled Trials; Recording of previous events; Recurrence; Recurrent Malignant Neoplasm; Reporting; Research; Resources; Risk Reduction; Scientist; Solid; Specimen; Structure; Survival Rate; Symptoms; Technology; Testing; Training; Treatment Efficacy; Trust; Vulnerable Populations; Woman; Work; adjuvant endocrine therapy; behavior test; behavioral clinical trial; black patient; black women; cancer care; cancer diagnosis; cancer health disparity; cancer recurrence; candidate identification; care delivery; career; career development; comparative efficacy; disparity reduction; efficacy evaluation; efficacy trial; experience; health care disparity; health disparity populations; hormone receptor-positive; hormone therapy; improved; innovation; intervention participants; intervention refinement; mHealth; mHealth methodology; malignant breast neoplasm; medication compliance; pilot test; programs; racial diversity; racism; randomized trial; randomized, clinical trials; recruit; skills; social cognitive theory; survival disparity; symposium; symptom management; tailored messaging; theories; therapy adherence; therapy development; treatment as usual; urinary

PROJECT SUMMARY Candidate Goals. My career goal is to reduce breast cancer health disparities in outcomes by addressing cancer care delivery issues in minority cancer populations. I received a solid foundation in observational epidemiological methods which I have applied to cancer survivorship research, but my training has not provided the skills I need to develop mHealth behavioral interventions or culturally-tailor and test behavioral interventions. The K08 provides an ideal opportunity to develop the necessary skills to achieve my long-term career goal as an independent clinical scientist. Candidate Career Development Plan. In this application, I propose training to develop the skills necessary to become a leader in the field of developing mHealth behavioral interventions for medication adherence and other cancer care delivery issues in minority cancer survivors. Training will be obtained through participation in scientific conferences, methods workshop, coursework, and structed mentorship from experts in developing culturally tailored behavioral interventions (Dr. Clement Gwede), adherence to endocrine therapy among patients with breast cancer (Dr. Dawn Hershman), mHealth methodology (Dr. Brian Gonzalez), randomized clinical trials of behavioral interventions (Dr. Heather Jim), recruitment and retention of minority participants to clinical studies (Dr. Susan Vadaparampil), and Biospecimen quality and testing (Dr. Shelley Tworoger). This training will ensure that I achieve my short-term goals after which I will be uniquely positioned to bridge gaps across disciplines, including: 1) Clinical breast cancer care, 2) Behavioral intervention development, cultural tailoring, and testing, and 3) Using mobile health technologies and biologic specimens in studies among vulnerable populations. Institutional Environment. The research environment, facilities, and resources at Moffitt Cancer Center are ideal for career development and I have the full support of my Department Chair, Dr. Czerniecki and Associate Center Director of the Division of Population Sciences, Dr. Shelley Tworoger. Research Plan. We propose an iterative approach to develop and pilot test a new mHealth behavioral intervention for AET adherence that is culturally tailored to Black breast cancer survivors. We will first use qualitative methods informed by Black breast cancer survivors to develop a blueprint of the intervention (Aim 1). We will then iteratively refine and culturally tailor the mHealth intervention focusing on symptom monitoring and management (Aim 2). Lastly, we will test the intervention for acceptability, feasibility, and preliminary efficacy (Aim 3). This project will address quality of life (symptom burden) and care delivery (medication adherence) issues in a health disparity population.

项目摘要 候选目标。我的职业目标是通过解决结果来减少乳腺癌的健康差异 少数癌症人群中的癌症护理交付问题。我获得了观察性的坚实基础 我对癌症生存研究应用的流行病学方法，但我的培训尚未 如果我需要制定MHealth行为干预或文化范围和测试行为的技能 干预措施。 K08提供了发展必要技能以实现我长期的理想机会 作为独立临床科学家的职业目标。 候选职业发展计划。在此应用程序中，我建议培训以发展所需的技能 成为制定MHealth行为干预措施以遵守药物和的领导者 少数癌症幸存者中的其他癌症护理交付问题。培训将通过参加 科学会议，方法研讨会，课程工作以及专家开发专家的指导 具有文化量身定制的行为干预措施（Clement Gwede博士），遵守内分泌治疗 乳腺癌患者（Dawn Hershman博士），MHealth方法论（Brian Gonzalez博士），随机 行为干预措施的临床试验（Heather Jim博士），少数参与者的招聘和保留 临床研究（Susan Vadaparampil博士）和生物测试质量和测试（Shelley Tworoger博士）。这 培训将确保我实现自己的短期目标 跨学科，包括：1）临床乳腺癌护理，2）行为干预发展，文化 调整和测试，以及3）在研究中使用移动健康技术和生物标本 脆弱的人群。 机构环境。莫菲特癌症中心的研究环境，设施和资源是 我的部门主席Czerniecki博士和同事们得到了职业发展的理想选择 人口科学系中心主任雪莱·特鲁格（Shelley Tworoger）博士。 研究计划。我们提出了一种迭代方法来开发和试点测试新的MHealth行为 干预AET依从性，该依从性是针对黑色乳腺癌幸存者量身定制的。我们将首先使用 黑乳腺癌幸存者告知的定性方法开发了干预的蓝图（AIM 1）。然后，我们将迭代地完善，并在文化上量身定制侧重于症状监测的MHealth干预措施 和管理（目标2）。最后，我们将测试干预措施的可接受性，可行性和初步 功效（目标3）。该项目将解决生活质量（症状负担）和护理服务（药物治疗 依从性）在健康差异人群中的问题。