INTEGRATIVE BIOLOGY OF THE BRAIN, INFLAMMATION & ASTHMA

大脑的综合生物学，炎症

• 批准号: 7382205
• 负责人: ROBERT C ROSE
• 金额: $ 55.67万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7382205
• 关键词: INTEGRATIVE; BIOLOGY; BRAIN; INFLAMMATION; ASTHMA

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. DESCRIPTION (provided by applicant): Although associations between psychosocial processes and health outcomes have now been carefully documented for several diseases, the mechanisms by which such psychosocial processes specifically influence peripheral biology and modulate illness are unknown. This proposal seeks to place the brain squarely back into the equation so that we can mechanistically relate psychological processes as they are instantiated in the brain, which then signals the periphery to influence health and disease. Scientific progress in cognitive and affective neuroscience over the past decade has led to major advances in our understanding of circuitry underlining cognition and affect. What is less well known is how this circuitry signals the periphery to modulate peripheral biological events that are central to certain illnesses. The overall objective of this grant application is the development of an integrative approach to addressing these questions. We have selected asthma as a disease example in which to study these processes, and the proposed interdisciplinary project will focus initially on molecular targets and cascades in relation to neuroscience, inflammation, and respiratory biology. This proposal extends the work of an existing network that has collaborated in several interdisciplinary studies. The aims of this application are to support the continued development of the existing organizational structure. This will be accomplished by support of frequent meetings of the core group, joined on occasion by other experts from neuroscience, pulmonary physiology, and immunophysiology. The group will organize workshops and symposia to review current findings that point the way to new studies linking mind, brain and body interactions. Support is also requested for linking the training grants of the co-investigators to provide opportunities for trainees to move between laboratories. Future efforts will extend the collaborations linking brain imaging, expectancy and bronchial function in asthma, emphasizing the physiological mechanisms linking brain activity to the periphery. This will include studies of the modulation of bronchoconstriction, central-peripheral communication in inflammation in asthma and in wound healing, and how placebos may modify autonomic and immune markers. We believe this P20 can help to influence a new generation of biomedical scientists who conceptualize the brain and body as working together and who have the tools to examine this interaction

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。描述（由申请人提供）：尽管现已仔细记录了多种疾病的心理社会过程与健康结果之间的关联，但此类心理社会过程具体影响外周生物学和调节疾病的机制尚不清楚。该提议旨在将大脑重新纳入方程式，以便我们能够机械地关联大脑中实例化的心理过程，然后向外围发出信号以影响健康和疾病。过去十年中认知和情感神经科学的科学进步使我们对强调认知和情感的电路的理解取得了重大进展。鲜为人知的是，该电路如何向外周发出信号，以调节对某些疾病至关重要的外周生物事件。该赠款申请的总体目标是开发一种综合方法来解决这些问题。我们选择哮喘作为研究这些过程的疾病例子，拟议的跨学科项目将首先关注与神经科学、炎症和呼吸生物学相关的分子靶点和级联反应。该提案扩展了在多项跨学科研究中合作的现有网络的工作。 该应用程序的目的是支持现有组织结构的持续发展。这将通过核心小组频繁会议的支持来实现，神经科学、肺生理学和免疫生理学的其他专家有时也会加入。该小组将组织研讨会和座谈会，回顾当前的研究结果，为连接心灵、大脑和身体相互作用的新研究指明道路。还要求支持将联合研究者的培训补助金联系起来，为受训人员在实验室之间流动提供机会。未来的努力将扩大与哮喘的脑成像、预期和支气管功能联系起来的合作，强调将大脑活动与外周联系起来的生理机制。这将包括对支气管收缩的调节、哮喘炎症和伤口愈合中的中枢-外周通讯的研究，以及安慰剂如何改变自主神经和免疫标志物。我们相信这个 P20 可以帮助影响新一代生物医学科学家，他们将大脑和身体视为协同工作的概念，并拥有检查这种相互作用的工具