DE PEDIATRIC COBRE: ALTERATIONS AND RENOVATIONS CORE

DE PEDIATRIC COBRE：改造和翻新核心

• 批准号: 7382176
• 负责人: PAUL M FAWCETT
• 金额: $ 41.19万
• 依托单位: ALFRED I. DU PONT HOSP FOR CHILDREN
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7382176
• 关键词: DE; PEDIATRIC; COBRE; ALTERATIONS; RENOVATIONS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Life Science Center (LSC) at the Alfred I duPont Hospital for Children in Wilmington, Delaware is a Nemours-funded core facility designed for conducting biomedical research using animal models of human disease. The physical plant encompasses approximately 7,000 sq ft of research laboratory, maintenance and animal holding facilties. There are 10 animal holding rooms, 4 wet laboratories or small animal procedure rooms, 1 major surgery room, 1 imaging and procedure suite, and an irradiation room, in addition to storage rooms and an automated cleaning room. Staffing of the center includes a manager, two animal caretakers, a surgical services technician and an attending veterinarian. The existing physical plant is located in a separate building. The physical plant is aging and in addition to the need for expanded space, upgrades to critical infrastructure components such as the electrical system and the HVAC system are critically needed. In addition, there is an LSC Annex consisting of two small rooms (G46/48) located on the ground floor of the Research building and currently unable to be utilized for survival surgery. The LSC had its last significant upgrade in the late 1980s. Nemours Biomedical Research has grown significantly since then, with escalation in the number and scope of researchers utilizing the LSC. Proposed facility modifications in support of this RFA are enumerated below. PROPOSED RENOVATIONS AND ALTERATIONS TO FACILITIES A. Large animal holding room and storage area. The projects of Drs. Theroux and Tsuda require the use of large animals (sheep and/or pigs). To accommodate these needs, the current LSC general storage room (109) will be modified to meet animal housing and storage requirements. Renovations to Room 109 will include the addition of a dividing wall to produce two separate rooms. One room will be labeled as 109A and will remain in use for LSC storage; Room 109B will become a holding/housing room for large animals. B. Recovery surgery suite for large animals. Projects proposed by Drs. Theroux and Tsuda necessitate the establishment of an animal surgery suite meeting the requirements of a survival surgery facility for covered species. The LSC Annex, Room G46/48, is currently used to perform non-survival surgery on large animals. The square footage in G46/48 at present is approximately 500 sq ft. The objective of the Renovation Core is to provide a significant upgrade to our existing vivarium facilities (Nemours Life Science Center). As noted above, the Life Science Center is a Nemours-funded core facility designed for conducting biomedical research using animal models of human disease. This staff facility currently meets the needs of many studies involving rodents and lagomorphs. We anticipate that the Center for Pediatric Research will significantly increased demands for vivarium space and will initiate the use of new animal models within Nemours Biomedical Research Institute. While the animal facility is sufficient for current small animal work, it does not meet the needs of several researchers who require or will require specialized physiological studies in small animals, nor does it provide sufficient large animal vivarium or procedure areas that will be essential for developing translational research programs with child-relevant animal models. The planned renovations will create a large animal holding room, a procedure room for survival surgery on large animals and a procedure room for survival surgery on small animals.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。特拉华州威尔明顿市Alfred I Dupont儿童医院的生命科学中心（LSC）是由Nemours资助的核心设施，旨在使用人类疾病动物模型进行生物医学研究。物理植物包括大约7,000平方英尺的研究实验室，维护和动物持有式的。除储藏室和一个自动清洁室外，还有10个动物握住房间，4个湿实验室或小动物程序室，1个主要手术室，1个成像和手术套件以及一个辐射室。该中心的人员配备包括一名经理，两名动物护理人员，一名外科服务技术员和一名参加兽医。 现有的物理工厂位于单独的建筑物中。物理植物正在衰老，除了需要扩大空间外，还需要至关重要的基础设施组件（例如电气系统和HVAC系统）。此外，还有一个LSC附件，该附件由位于研究大楼底层的两个小房间（G46/48）组成，目前无法用于生存手术。 LSC在1980年代后期进行了最后一次重大升级。自那时以来，Nemours生物医学研究已经显着增长，研究人员使用LSC的数量和范围升级。下面列举了建议支持此RFA的设施修改。 提议的装修和设施的改建A.大型动物持有室和储藏区。博士的项目。 Theroux和Tsuda需要使用大型动物（绵羊和/或猪）。为了满足这些需求，将修改当前LSC通用储藏室（109）以满足动物住房和存储要求。对109室的翻新将包括增加一个分隔墙以生产两个独立的房间。一个房间将被标记为109a，并将保留用于LSC存储； 109b房间将成为大型动物的藏室/住房室。 B.大型动物的恢复手术套件。博士提出的项目。 Theroux和Tsuda需要建立一个符合覆盖物种生存手术设施的要求的动物手术套件。 LSC Annex，G46/48室，目前用于对大型动物进行非生存手术。目前，G46/48中的平方英尺约为500平方英尺。翻新核心的目的是为我们现有的Vivarium设施（Nemours Life Science Center）提供重大升级。如上所述，Life Science Center是Nemours资助的核心设施，旨在使用人类疾病动物模型进行生物医学研究。目前，该员工设施满足了许多涉及啮齿动物和lagomorphs的研究的需求。我们预计，小儿研究中心将显着增加对体内空间的需求，并将在Nemours生物医学研究所内使用新动物模型。尽管动物设施足以容纳当前的小动物工作，但它不符合需要或需要在小动物中进行专门生理学研究的一些研究人员的需求，也不提供足够的大型动物植物或程序领域，这对于使用儿童相关动物模型开发转化研究计划至关重要。计划进行的翻新将创建一个大型动物持有室，大型动物生存手术的程序室以及小动物生存手术的程序室。