PREVALENCE OF GSTM1, GSTT1, AND GSTP1B AMONG HISPANICS IN PUERTO RICO

波多黎各西班牙裔人群中 GSTM1、GSTT1 和 GSTP1B 的患病率

• 批准号: 7381029
• 负责人: JOSE F RODRIGUEZ-ORENGO
• 金额: $ 6.07万
• 依托单位: UNIVERSITY OF PUERTO RICO MED SCIENCES
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7381029
• 关键词: PREVALENCE; GSTM1; GSTT1; GSTP1B; AMONG

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Lung cancer stills a major public health problem in the U.S. and P.R. Risk factors for lung cancer are cigarette smoking, environmental factors, and genetic predisposition. In relation to the genetic predisposition, although 80 to 90% of patients with lung cancer are smokers only 10% of smokers will develop lung cancer. Susceptibility differences to carcinogens present in cigarette smoke are generally thought to result from differences in the genetic background of individuals. Glutathione S-transferases (GSTs) are a family of inducible enzymes used in the detoxification of different xenobiotics in mammals. Several studies have shown an association for the lack of GSTM1, GSTT1, and the presence of GSTP1b with prevalence and progression of lung cancer. Most of these studies have focused in the Caucasian and African American populations, and there is limited information regarding the Hispanic population. Thus, as a first step to fill this void in the Hispanic population we proposed to obtain the prevalence of these genes in the general population. This information will allow us to better design future analytical studies on lung cancer interventions and gene-environment interactions. To accomplish the objective of this application, we will pursue the following specific aims: 1. To screen 250 Hispanic subjects from Puerto Rico using saliva samples and determine the prevalence of GSTM1 (null), GSTT1 (null), and GSTP1b (ile/val). 2. To evaluate the distribution of known risk factors (smoking, occupational hazard, etc.) for lung cancer by GST categories. 3. To characterize the sample population by demographic characteristics (i.e. gender, age, etc.) as well as by lifestyle and health related variables.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。肺癌是美国的主要公共卫生问题，肺癌的危险因素是吸烟，环境因素和遗传易感性。与遗传易感性有关，尽管80％至90％的肺癌患者是吸烟者，只有10％的吸烟者会患上肺癌。通常认为，个体遗传背景的差异，对香烟烟雾中存在的致癌物的敏感性差异。谷胱甘肽S-转移酶（GSTS）是一种用于哺乳动物不同异种生物学排毒的诱导酶家族。几项研究表明，缺乏GSTM1，GSTT1以及GSTP1B的存在与肺癌的患病率和进展有关。这些研究大多数都集中在高加索人和非裔美国人的人群中，并且有关西班牙裔人口的信息有限。因此，作为填补西班牙裔人群中这种空隙的第一步，我们提议在普通人群中获得这些基因的流行。这些信息将使我们能够更好地设计有关肺癌干预和基因环境相互作用的未来分析研究。 为了实现此应用程序的目标，我们将追求以下具体目的：1。使用唾液样本从波多黎各筛选250名西班牙裔受试者，并确定GSTM1（NULL），GSTT1（NULL）（NULL）和GSTP1B（ILE/VAL）的患病率。 2。评估GST类别的肺癌的已知危险因素（吸烟，职业危害等）的分布。 3。通过人口统计学特征（即性别，年龄等）以及生活方式和与健康相关的变量来表征样本人群。