CORRELATION ON THE PHARMACOKINETICS AND TOXICITY OF CPT-11 WITH FUNCTIONALLY

CPT-11的药代动力学和毒性与功能的相关性

• 批准号: 7375615
• 负责人: ALBERT CRAIG LOCKHART
• 金额: $ 0.13万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7375615
• 关键词: CORRELATION; PHARMACOKINETICS; TOXICITY; CPT; 11

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Subjects with allelic variations in MRP2 that result in altered MRP2 transporter function will demonstrate altered pharmacokinetics and a different incidence of GI toxicity after treatment with CPT-11.

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构适用于该中心，这不一定是调查员的机构。在MRP2中导致MRP2转运蛋白功能改变的受试者将证明药代动力学的改变，并且在用CPT-11治疗后，GI毒性的发生率不同。